1is7

Crystal structure of rat GTPCHI/GFRP stimulatory complex

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP Cyclohydrolase I

Rattus norvegicus

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 20	GTP Cyclohydrolase I Feedback Regulatory Protein × 10 （P70552） POTASSIUM ION × 10 PHENYLALANINE × 10 water × 19	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	GCH1_RAT
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–230； UniProt 12–241 作者链 B； PDB构建体 1–230； UniProt 12–241 作者链 C； PDB构建体 1–230； UniProt 12–241 作者链 D； PDB构建体 1–230； UniProt 12–241 作者链 E； PDB构建体 1–230； UniProt 12–241 作者链 F； PDB构建体 1–230； UniProt 12–241 作者链 G； PDB构建体 1–230； UniProt 12–241 作者链 H； PDB构建体 1–230； UniProt 12–241 作者链 I； PDB构建体 1–230； UniProt 12–241 作者链 J； PDB构建体 1–230； UniProt 12–241

GTP Cyclohydrolase I Feedback Regulatory Protein

Rattus norvegicus

UniProt P70552

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 20	GTP Cyclohydrolase I × 10 （P22288） POTASSIUM ION × 10 PHENYLALANINE × 10 water × 19	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	GFRP_RAT
Isoform	—
PDB实体	2
链与序列区间	作者链 K； PDB构建体 1–84； UniProt 0–83 作者链 L； PDB构建体 1–84； UniProt 0–83 作者链 M； PDB构建体 1–84； UniProt 0–83 作者链 N； PDB构建体 1–84； UniProt 0–83 作者链 O； PDB构建体 1–84； UniProt 0–83 作者链 P； PDB构建体 1–84； UniProt 0–83 作者链 Q； PDB构建体 1–84； UniProt 0–83 作者链 R； PDB构建体 1–84； UniProt 0–83 作者链 S； PDB构建体 1–84； UniProt 0–83 作者链 T； PDB构建体 1–84； UniProt 0–83

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1is7
沉积日期 deposition_date	2001-11-18
结构标题 title	Crystal structure of rat GTPCHI/GFRP stimulatory complex
关键词 keywords	ENZYME-REGULATORY PROTEIN COMPLEX, HYDROLASE-PROTEIN BINDING COMPLEX; HYDROLASE/PROTEIN BINDING
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1is7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1is7__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1is7__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	43.13 Å
Rg（电子密度）	42.36 Å
总 Rg	42.64 Å
原子数	22250
残基数	2780
排除体积	398860 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1is7__assembly_1__model_1`	eicosameric （20）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

描述 description	GTP Cyclohydrolase I
分子量 formula_weight	25819.7 kDa
EC 编号 ec_number	3.5.4.16
来源方法 src_method	man
拷贝数 entity_count	10

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J
原子数 atom_count	22375

GFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

来源 Source

来源生物 organism	Rattus norvegicus
通用名 common_name	Norway rat
NCBI 分类编号 ncbi_taxonomy_id	10116
宿主生物 host_organism	Escherichia coli

实体 2 Entity 2 polymer

描述 description	GTP Cyclohydrolase I Feedback Regulatory Protein
分子量 formula_weight	9683.2 kDa
来源方法 src_method	man
拷贝数 entity_count	10

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	K,L,M,N,O,P,Q,R,S,T

MPYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNFYEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWCLHKE

来源 Source

来源生物 organism	Rattus norvegicus
通用名 common_name	Norway rat
NCBI 分类编号 ncbi_taxonomy_id	10116
宿主生物 host_organism	Escherichia coli

实体 3 Entity 3 non-polymer

描述 description	POTASSIUM ION
分子量 formula_weight	39.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 4 Entity 4 non-polymer

描述 description	PHENYLALANINE
分子量 formula_weight	165.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 5 Entity 5 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	125

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6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

结构域编号 domain_id	d1is7a_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7b_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7c_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7d_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7e_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7f_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7g_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7h_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7i_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7j_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1is7k_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7l_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7m_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7n_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7o_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7p_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7q_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7r_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7s_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1is7t_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

CATH v4.4 (30 domains)

结构域编号 domain_id	1is7A01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7A02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7B01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7B02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7C01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7C02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7D01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7D02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7E01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7E02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7F01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7F02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7G01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7G02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7H01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7H02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7I01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7I02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7J01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1is7J02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1is7K00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7L00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7M00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7N00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7O00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7P00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7Q00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7R00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7S00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1is7T00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

▶

晶胞边长 a length_a	124.151 Å
晶胞边长 b length_b	111.723 Å
晶胞边长 c length_c	126.108 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	97.37 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	20

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.800 Å
最低分辨率 resolution_low	15.000 Å
R 因子 r_factor	—
R_work r_work	0.2280
R_free r_free	0.2640

Crystal structure of rat GTPCHI/GFRP stimulatory complex

1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP Cyclohydrolase I

当前结构中的状态

数据库中的同蛋白其他状态

GTP Cyclohydrolase I Feedback Regulatory Protein

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1is7__assembly_1__model_1

1is7__assembly_1__model_1 | I(q)

1is7__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 water

6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. 引用文献 (1)

Crystal structure of rat GTPCHI/GFRP stimulatory complex

1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP Cyclohydrolase I

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

GTP Cyclohydrolase I Feedback Regulatory Protein

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1is7__assembly_1__model_1

1is7__assembly_1__model_1 | I(q)

1is7__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 water

6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. 引用文献 (1)