Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | S-ADENOSYL-L-HOMOCYSTEINE × 1 QUINACRINE × 1 water × 1 | 与蛋白数一致 |
| 2 | 蛋白单体 | 单体 | 蛋白 1 | S-ADENOSYL-L-HOMOCYSTEINE × 1 UNKNOWN ATOM OR ION × 7 water × 1 | 与蛋白数一致 |
| UniProt名称 | HNMT_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–292； UniProt 1–292 作者链 B； PDB构建体 1–292； UniProt 1–292 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 1jqe |
| 沉积日期 deposition_date | 2001-08-06 |
| 结构标题 title | Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine |
| 关键词 keywords | Classic methyltransferase fold, protein-substrate-cofactor complex, polymorphic variant, TRANSFERASE; TRANSFERASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 20.05 Å |
| Rg（电子密度） | 18.85 Å |
| 总 Rg | 19.68 Å |
| 原子数 | 2227 |
| 残基数 | 280 |
| 排除体积 | 39727 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d1jqea_ |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.66 — S-adenosyl-L-methionine-dependent methyltransferases |
| 超家族 Superfamily superfamily | c.66.1 — S-adenosyl-L-methionine-dependent methyltransferases |
| 家族 Family family | c.66.1.19 — Histamine methyltransferase |
| 结构域编号 domain_id | d1jqeb_ |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.66 — S-adenosyl-L-methionine-dependent methyltransferases |
| 超家族 Superfamily superfamily | c.66.1 — S-adenosyl-L-methionine-dependent methyltransferases |
| 家族 Family family | c.66.1.19 — Histamine methyltransferase |
| 结构域编号 domain_id | 1jqeA00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 150 — Vaccinia Virus protein VP39 |
| 结构域编号 domain_id | 1jqeB00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 150 — Vaccinia Virus protein VP39 |