1k0u

;Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine ;

Method: X-RAY DIFFRACTION Dmax: 167.9 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 1k0u

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1k0u
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1k0u
沉积日期 deposition_date2001-09-20
结构标题 title;Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine ;
关键词 keywordsS-adenosylhomocysteine, hydrolase, D-eritadenine, inhibitor; HYDROLASE
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier50.11
回转半径 Rg (电子) rg_electron50.19
零角强度 I(0) i02131500000.00
分子量 molecular_weight385960.0 kDa
排除体积 excluded_volume482840 ų
包络体积 envelope_volume580800 ų
水化壳体积 shell_volume94046 ų
包络直径 envelope_diameter175.3
壳层 Rg shell_rg55.40
包络 Rg envelope_rg49.63
形状 Rg shape_rg50.21
总 Rg total_rg50.25
总原子数 total_atoms27048
残基数 n_residues3440
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax167.9
Rg (实空间) rg_real50.14
Rg 误差 (实空间) rg_real_error1.23
I(0) (实空间) i0_real2.1320e+09
I(0) 误差 (实空间) i0_real_error4.1540e+07
Rg (倒空间) rg_reciprocal50.07
I(0) (倒空间) i0_reciprocal2131000000.0000
解质量估计 total_estimate0.8773
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks1
主峰位置 r_peak_primary54.2
偏度 Skewness skewness0.343
峰度 Kurtosis kurtosis-0.493
角度范围 angular_range— – 0.1550 −1
当前正则化参数 α current_alpha0.0002
最高正则化参数 α highest_alpha233500000.0000
实空间数据点数 n_real_points32
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.869; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.986; Smooth: 0.807

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (4)

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd1k0ua1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0ua2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0ub1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0ub2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0uc1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0uc2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0ud1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0ud2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0ue1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0ue2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0uf1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0uf2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0ug1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0ug2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase
结构域编号 domain_idd1k0uh1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.4 — Formate/glycerate dehydrogenases, NAD-domain
结构域编号 domain_idd1k0uh2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.12 — Formate/glycerate dehydrogenase catalytic domain-like
家族 Family familyc.23.12.3 — S-adenosylhomocystein hydrolase

CATH v4.4 (16 domains)

结构域编号 domain_id1k0uA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uA02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uB01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uB02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uC01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uC02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uD01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uD02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uE01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uE02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uF01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uF02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uG01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uG02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1k0uH01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1480 — Adenosylhomocysteinase-like
结构域编号 domain_id1k0uH02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain

7. 引用文献 (1)

8. 文件与曲线 (10)