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1lxf

Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES

Homo sapiens

UniProt P63316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Troponin I, cardiac muscle × 1 （P19429） CALCIUM ION × 1 1-ISOBUTOXY-2-PYRROLIDINO-3[N-BENZYLANILINO] PROPANE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ap4 1ih0 1spy 2jt0 2jt3 2jt8 2jtz 2jxl 2kdh 2kfx 2l98 2mle

23 assemblies; showing the first 12

Homodimer
1wrk 1wrl 1wrl 1wrl 4gje 4gjf 4gjg

7 assemblies

Homotetramer

None

Other homooligomers
3rv5

1 assemblies

Heteromeric or nucleic-acid complex
1j1d 1j1d 1j1e 1j1e 1lxf 1mxl 1ozs 2kgb 2krd 2l1r 2mkp 2mzp

49 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNNC1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain C； PDBConstruct 1–89； UniProt 1–89

Troponin I, cardiac muscle

OrganismNot specified

UniProt P19429

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES × 1 （P63316） CALCIUM ION × 1 1-ISOBUTOXY-2-PYRROLIDINO-3[N-BENZYLANILINO] PROPANE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1j1d 1j1d 1j1e 1j1e 1lxf 1mxl 1ozs 2kgb 2krd 2l1r 2mzp 2n7l

49 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNNI3_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain I； PDBConstruct 1–17； UniProt 148–164

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1lxf
Deposition date deposition_date2002-06-05
Structure title titleStructure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil
Keywords keywordsmuscle, cardiac troponin C-drug interaction, bepridil, cardiac troponin I-drug interaction, METAL BINDING PROTEIN, PROTEIN BINDING; METAL BINDING PROTEIN, PROTEIN BINDING
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1lxf__assembly_1__model_8

Assembly 1 · Model 8 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1lxf__assembly_1__model_8 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1lxf__assembly_1__model_8 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.39 Å
Rg (electron density)13.74 Å
Total Rg15.04 Å
Atom count1687
Residues106
Excluded volume15232 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1lxf__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 1lxf__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 1lxf__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 1lxf__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 1lxf__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 1lxf__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 1lxf__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 1lxf__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 1lxf__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 1lxf__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 1lxf__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 1lxf__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 1lxf__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 1lxf__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 1lxf__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 1lxf__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 1lxf__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 1lxf__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 1lxf__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 1lxf__assembly_1__model_20 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 1lxf__assembly_1__model_21 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 1lxf__assembly_1__model_22 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 1lxf__assembly_1__model_23 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 1lxf__assembly_1__model_24 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 1lxf__assembly_1__model_25 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 26 1lxf__assembly_1__model_26 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 27 1lxf__assembly_1__model_27 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 28 1lxf__assembly_1__model_28 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 29 1lxf__assembly_1__model_29 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 30 1lxf__assembly_1__model_30 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1lxfc_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
Domain ID domain_idd1lxfi_
Class classj — Peptides
Fold Fold foldj.22 — Troponin I fragments
Superfamily Superfamily superfamilyj.22.1 — Troponin I fragments
Family Family familyj.22.1.1 — Troponin I fragments

CATH v4.4 (1 domains)

Domain ID domain_id1lxfC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
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7. Citations (1)