Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白异源复合物 | 异源复合物 | 蛋白 4 | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide × 2 water × 4 | 与蛋白数一致 |
| 2 | 蛋白异源复合物 | 异源复合物 | 蛋白 4 | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide × 2 water × 4 | 与蛋白数一致 |
| UniProt名称 | CATL_HUMAN |
| Isoform | — |
| PDB实体 | 1, 2 |
| 链与序列区间 | 作者链 A； PDB构建体 1–175； UniProt 114–288 作者链 B； PDB构建体 1–175； UniProt 114–288 作者链 C； PDB构建体 1–42； UniProt 292–333 作者链 D； PDB构建体 1–42； UniProt 292–333 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 1mhw |
| 沉积日期 deposition_date | 2002-08-21 |
| 结构标题 title | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides |
| 关键词 keywords | CATHEPSIN L, CYSTEINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HYDROLASE/HYDROLASE INHIBITOR |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 17.44 Å |
| Rg（电子密度） | 16.34 Å |
| 总 Rg | 17.36 Å |
| 原子数 | 1739 |
| 残基数 | 217 |
| 排除体积 | 30533 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d1mhw.1 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.3 — Cysteine proteinases |
| 超家族 Superfamily superfamily | d.3.1 — Cysteine proteinases |
| 家族 Family family | d.3.1.1 — Papain-like |
| 结构域编号 domain_id | d1mhw.2 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.3 — Cysteine proteinases |
| 超家族 Superfamily superfamily | d.3.1 — Cysteine proteinases |
| 家族 Family family | d.3.1.1 — Papain-like |
| 结构域编号 domain_id | 1mhwA00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 90 — Alpha-Beta Complex |
| 拓扑 Topology topology | 70 — Cathepsin B; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Cysteine proteinases |
| 结构域编号 domain_id | 1mhwB00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 90 — Alpha-Beta Complex |
| 拓扑 Topology topology | 70 — Cathepsin B; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Cysteine proteinases |
| 结构域编号 domain_id | 1mhwC00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
| 同源超家族 H-superfamily homologous superfamily | 170 — Cysteine proteinases. Chain C |
| 结构域编号 domain_id | 1mhwD00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
| 同源超家族 H-superfamily homologous superfamily | 170 — Cysteine proteinases. Chain C |