THYMIDINE PHOSPHORYLASE
物种未注明
当前结构中的状态
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白同源多聚体 | 同源多聚体 | 蛋白 2 | 无其他共同聚合物 | 与蛋白数一致 |
数据库中的同蛋白其他状态
查看构建体与数据证据
| UniProt名称 | TYPH_ECOLI |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 2–440； UniProt 2–440 |
1otp
STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE
1. 蛋白身份与相关结构 Protein Identity & Related Structures
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
2. 结构基本信息 2. Structure Basics
| 条目编号 entry_id | 1otp |
| 沉积日期 deposition_date | 1997-11-09 |
| 结构标题 title | STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE |
| 关键词 keywords | PHOSPHORYLASE, PYRIMIDINE METABOLISM, SALVAGE PATHWAY, DOMAIN MOVEMENT, TRANSFERASE, GLYCOSYLTRANSFERASE; PHOSPHORYLASE |
| 实验方法 method | X-RAY DIFFRACTION |
3. Official assembly/model 理论 SAXS Official SAXS Profiles
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
1otp__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
1otp__assembly_1__model_1 | I(q)
1otp__assembly_1__model_1 | P(r) · Pending
| Rg（Guinier） | 37.56 Å |
| Rg（电子密度） | 37.55 Å |
| 总 Rg | 37.68 Å |
| 原子数 | 6612 |
| 残基数 | 880 |
| 排除体积 | 118020 ų |
| 最大 q | 0.500 Å⁻¹ |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合物信息 Entities & Polymers (1)
6. 折叠分类 (SCOP + CATH) 7 domains
SCOP 2.08 (4 domains)
| 结构域编号 domain_id | d1otpa1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.46 — Methionine synthase domain-like |
| 超家族 Superfamily superfamily | a.46.2 — Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| 家族 Family family | a.46.2.1 — Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| 结构域编号 domain_id | d1otpa2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.27 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 超家族 Superfamily superfamily | c.27.1 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 家族 Family family | c.27.1.1 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 结构域编号 domain_id | d1otpa3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.41 — alpha/beta-Hammerhead |
| 超家族 Superfamily superfamily | d.41.3 — Pyrimidine nucleoside phosphorylase C-terminal domain |
| 家族 Family family | d.41.3.1 — Pyrimidine nucleoside phosphorylase C-terminal domain |
| 结构域编号 domain_id | d1otpa4 |
| 类 Class class | l — Artifacts |
| 折叠类型 Fold fold | l.1 — Tags |
| 超家族 Superfamily superfamily | l.1.1 — Tags |
| 家族 Family family | l.1.1.1 — Tags |
CATH v4.4 (3 domains)
| 结构域编号 domain_id | 1otpA01 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 20 — Up-down Bundle |
| 拓扑 Topology topology | 970 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C |
| 结构域编号 domain_id | 1otpA02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 1030 — Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 结构域编号 domain_id | 1otpA03 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 90 — Alpha-Beta Complex |
| 拓扑 Topology topology | 1170 — Aldehyde Oxidoreductase; domain 3 |
| 同源超家族 H-superfamily homologous superfamily | 30 — Pyrimidine nucleoside phosphorylase-like, C-terminal domain |