1oxq

Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

Method: X-RAY DIFFRACTION D_max: 97.3 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Baculoviral IAP repeat-containing protein 7

Homo sapiens

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 A； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
10	蛋白同源多聚体同源多聚体蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 A； UniProt 63–179 链 D； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 2 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
11	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 E； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
2	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 B； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
3	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 C； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
4	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 D； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 1 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
5	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 E； UniProt 63–179	片段：BIR domain, residues 63-179	AVPIAQKSE (Smac) peptide × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
6	蛋白异源复合物异源复合物蛋白 × 6 PDB 声明：hexameric（6）与蛋白拷贝数一致	链 A； UniProt 63–179 链 B； UniProt 63–179 链 C； UniProt 63–179 链 D； UniProt 63–179 链 E； UniProt 63–179	片段：BIR domain, residues 63-179	AVPIAQKSE (Smac) peptide × 1 ZN ZINC ION × 5 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
7	蛋白异源复合物异源复合物蛋白 × 4 PDB 声明：tetrameric（4）与蛋白拷贝数一致	链 A； UniProt 63–179 链 D； UniProt 63–179 链 E； UniProt 63–179	片段：BIR domain, residues 63-179	AVPIAQKSE (Smac) peptide × 1 ZN ZINC ION × 3 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
8	蛋白同源多聚体同源多聚体蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 B； UniProt 63–179 链 C； UniProt 63–179	片段：BIR domain, residues 63-179	ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218
9	蛋白异源复合物异源复合物蛋白 × 3 PDB 声明：trimeric（3）与蛋白拷贝数一致	链 D； UniProt 63–179 链 E； UniProt 63–179	片段：BIR domain, residues 63-179	AVPIAQKSE (Smac) peptide × 1 ZN ZINC ION × 2 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.218

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 1OXQ	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 10 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179 链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 2 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 11 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179 链 B 63–179（117 aa）片段：BIR domain, residues 63-179 链 C 63–179（117 aa）片段：BIR domain, residues 63-179 链 D 63–179（117 aa）片段：BIR domain, residues 63-179 链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 5 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179 链 D 63–179（117 aa）片段：BIR domain, residues 63-179 链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 3 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 8 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 63–179（117 aa）片段：BIR domain, residues 63-179 链 C 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OXN Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 63–179（117 aa）片段：BIR domain, residues 63-179 链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 2 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.20 Å R-free 0.225
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179 链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 2 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 7 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 63–179（117 aa）片段：BIR domain, residues 63-179 链 C 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1OY7 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 提交 2003-04-03	实验环境不同结构质量不同	Assembly 8 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；sodium acetate, PEG 300, DTT , pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.70 Å R-free 0.211
1TW6 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 提交 2004-06-30	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 63–171（109 aa）片段：ML-IAP residues 63-172	突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；lithium sulfate, Bis-tris, PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.171
1TW6 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 提交 2004-06-30	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 63–171（109 aa）片段：ML-IAP residues 63-172	突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L	ZN ZINC ION × 1 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；lithium sulfate, Bis-tris, PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.171
1TW6 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 提交 2004-06-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 63–171（109 aa）片段：ML-IAP residues 63-172 链 B 63–171（109 aa）片段：ML-IAP residues 63-172	突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L 突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L	ZN ZINC ION × 4 LI LITHIUM ION × 2 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2 EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；lithium sulfate, Bis-tris, PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.171
1TW6 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 提交 2004-06-30	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 63–171（109 aa）片段：ML-IAP residues 63-172 链 B 63–171（109 aa）片段：ML-IAP residues 63-172	突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L 突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L	ZN ZINC ION × 2 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；lithium sulfate, Bis-tris, PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.171
1TW6 Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 提交 2004-06-30	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 63–171（109 aa）片段：ML-IAP residues 63-172	突变：S150G, R160G, D161E, F162Y, V163I, H164N, S165N, V166I, Q167H, E168L, Q172L	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；lithium sulfate, Bis-tris, PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.171
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 1 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172 链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES 突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 4 LI LITHIUM ION × 2 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2 EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172 链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES 突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 2 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172 链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES 突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 4 LI LITHIUM ION × 2 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2 EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172 链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES 突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 4 LI LITHIUM ION × 2 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2 EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3H Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172 链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES 突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 2 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.62 Å R-free 0.180
2I3I Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 1 618 (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 2.30 Å R-free 0.224
2I3I Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic 提交 2006-08-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 63–172（110 aa）片段：ML-IAP residues 63-172	突变：RESIDUES 150, 160-168, AND 172 REPLACED WITH XIAP-BIR3 HOMOLOGUES	ZN ZINC ION × 1 618 (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE × 1 LI LITHIUM ION × 1 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；Lithium sulfate, PEG 3350, Bis-tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 2.30 Å R-free 0.224
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 E 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 1 389 L-alanyl-L-valyl-N-(2,2-diphenylethyl)-L-prolinamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3F7G Structure of the BIR domain from ML-IAP bound to a peptidomimetic 提交 2008-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 63–179（117 aa）片段：BIR domain, residues 63-179 链 B 63–179（117 aa）片段：BIR domain, residues 63-179 链 C 63–179（117 aa）片段：BIR domain, residues 63-179 链 D 63–179（117 aa）片段：BIR domain, residues 63-179	未记录	ZN ZINC ION × 4 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；SODIUM ACETATE, PEG 300, DTT, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K	分辨率 2.30 Å R-free 0.209
3UW5 Crystal structure of the BIR domain of MLIAP bound to GDC0152 提交 2011-11-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 63–159（97 aa）片段：BIR domain 63-179	突变：S150G	ZN ZINC ION × 1 SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；292 K；Protein at 25 mg/mL in 10 mM MES was mixed with peptide (AVPW)n a 1:2 protein/peptide ratio. The MLIAP peptide complex was mixed with crystallization well solution (100 mM Bis tris(hydroxymethyl)aminomethane (tris), pH 6; 200 mM lithium sulfate; 20 25% (w/v) poly(ethylene glycol) 3350) in a ratio of 1 uL of protein complex to 1 uL of well solution, VAPOR DIFFUSION, temperature 292K	分辨率 1.71 Å R-free 0.166
3UW5 Crystal structure of the BIR domain of MLIAP bound to GDC0152 提交 2011-11-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 信息不足异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 63–159（97 aa）片段：BIR domain 63-179	突变：S150G	ZN ZINC ION × 1 SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；292 K；Protein at 25 mg/mL in 10 mM MES was mixed with peptide (AVPW)n a 1:2 protein/peptide ratio. The MLIAP peptide complex was mixed with crystallization well solution (100 mM Bis tris(hydroxymethyl)aminomethane (tris), pH 6; 200 mM lithium sulfate; 20 25% (w/v) poly(ethylene glycol) 3350) in a ratio of 1 uL of protein complex to 1 uL of well solution, VAPOR DIFFUSION, temperature 292K	分辨率 1.71 Å R-free 0.166
4AUQ Structure of BIRC7-UbcH5b-Ub complex. 提交 2012-05-21	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 239–298（60 aa）片段：RESIDUES 239-298 链 E 239–298（60 aa）片段：RESIDUES 239-298	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.18 Å R-free 0.249

共 8 个其他 PDB 条目、42 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	BIRC7_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 24–140； UniProt 63–179 作者链 B； PDB构建体 24–140； UniProt 63–179 作者链 C； PDB构建体 24–140； UniProt 63–179 作者链 D； PDB构建体 24–140； UniProt 63–179 作者链 E； PDB构建体 24–140； UniProt 63–179

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1oxq
沉积日期 deposition_date	2003-04-03
结构标题 title	Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
关键词 keywords	zinc binding, peptide complex, apoptosis inhibition, APOPTOSIS-peptide complex; APOPTOSIS/peptide
实验方法 method	X-RAY DIFFRACTION

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	27.69 Å
回转半径 Rg (电子) rg_electron	27.38 Å
零角强度 I(0) i0	53772700.00
分子量 molecular_weight	56775.0 kDa
排除体积 excluded_volume	70529 Å³
包络体积 envelope_volume	87868 Å³
水化壳体积 shell_volume	28178 Å³
包络直径 envelope_diameter	100.9 Å
壳层 Rg shell_rg	33.07 Å
包络 Rg envelope_rg	27.77 Å
形状 Rg shape_rg	27.40 Å
总 Rg total_rg	27.90 Å
总原子数 total_atoms	4006
残基数 n_residues	499
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	97.3 Å
Rg (实空间) rg_real	27.94 Å
Rg 误差 (实空间) rg_real_error	0.87 Å
I(0) (实空间) i0_real	5.3770e+07
I(0) 误差 (实空间) i0_real_error	8.2050e+05
Rg (倒空间) rg_reciprocal	27.86 Å
I(0) (倒空间) i0_reciprocal	53770000.0000
解质量估计 total_estimate	0.8369
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	30.7 Å
偏度 Skewness skewness	0.598
峰度 Kurtosis kurtosis	0.045
角度范围 angular_range	— – 0.2850 Å⁻¹
当前正则化参数 α current_alpha	0.0000
最高正则化参数 α highest_alpha	9416000.0000
实空间数据点数 n_real_points	58
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.732; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.856; Smooth: 0.825

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

描述 description	Baculoviral IAP repeat-containing protein 7
分子量 formula_weight	15749.4 kDa
来源方法 src_method	man
拷贝数 entity_count	5

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E
原子数 atom_count	4409

MGSSHHHHHHSSGLVPRGSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDP

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 2 Entity 2 polymer

描述 description	AVPIAQKSE (Smac) peptide
分子量 formula_weight	943.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	F

AVPIAQKSE

实体 3 Entity 3 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	5

实体 4 Entity 4 non-polymer

描述 description	3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL
分子量 formula_weight	326.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 5 Entity 5 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	403

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7. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

结构域编号 domain_id	d1oxqa_
类 Class class	g — Small proteins
折叠类型 Fold fold	g.52 — Inhibitor of apoptosis (IAP) repeat
超家族 Superfamily superfamily	g.52.1 — Inhibitor of apoptosis (IAP) repeat
家族 Family family	g.52.1.1 — Inhibitor of apoptosis (IAP) repeat

结构域编号 domain_id	d1oxqb_
类 Class class	g — Small proteins
折叠类型 Fold fold	g.52 — Inhibitor of apoptosis (IAP) repeat
超家族 Superfamily superfamily	g.52.1 — Inhibitor of apoptosis (IAP) repeat
家族 Family family	g.52.1.1 — Inhibitor of apoptosis (IAP) repeat

结构域编号 domain_id	d1oxqc_
类 Class class	g — Small proteins
折叠类型 Fold fold	g.52 — Inhibitor of apoptosis (IAP) repeat
超家族 Superfamily superfamily	g.52.1 — Inhibitor of apoptosis (IAP) repeat
家族 Family family	g.52.1.1 — Inhibitor of apoptosis (IAP) repeat

结构域编号 domain_id	d1oxqd_
类 Class class	g — Small proteins
折叠类型 Fold fold	g.52 — Inhibitor of apoptosis (IAP) repeat
超家族 Superfamily superfamily	g.52.1 — Inhibitor of apoptosis (IAP) repeat
家族 Family family	g.52.1.1 — Inhibitor of apoptosis (IAP) repeat

结构域编号 domain_id	d1oxqe_
类 Class class	g — Small proteins
折叠类型 Fold fold	g.52 — Inhibitor of apoptosis (IAP) repeat
超家族 Superfamily superfamily	g.52.1 — Inhibitor of apoptosis (IAP) repeat
家族 Family family	g.52.1.1 — Inhibitor of apoptosis (IAP) repeat

CATH v4.4 (5 domains)

结构域编号 domain_id	1oxqA00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1170 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
同源超家族 H-superfamily homologous superfamily	10 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

结构域编号 domain_id	1oxqB00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1170 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
同源超家族 H-superfamily homologous superfamily	10 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

结构域编号 domain_id	1oxqC00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1170 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
同源超家族 H-superfamily homologous superfamily	10 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

结构域编号 domain_id	1oxqD00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1170 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
同源超家族 H-superfamily homologous superfamily	10 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

结构域编号 domain_id	1oxqE00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1170 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
同源超家族 H-superfamily homologous superfamily	10 — Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

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8. 引用文献 (3)

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晶胞边长 a length_a	83.189 Å
晶胞边长 b length_b	83.189 Å
晶胞边长 c length_c	93.612 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	15

空间群 space_group	P 32
空间群编号 int_tables_number	145
晶系 crystal_system	—

分辨率 resolution	2.300 Å
最低分辨率 resolution_low	20.000 Å
R 因子 r_factor	0.1635
R_work r_work	0.1606
R_free r_free	0.2183

fit	/app/data/saxs_computation/ox/1oxq/1oxq.fit
pddf	/app/data/pr_computation/ox/1oxq/1oxq.pr.out
profile	/app/data/saxs_computation/ox/1oxq/1oxq.dat

Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Baculoviral IAP repeat-containing protein 7

当前结构中的状态

数据库中的同蛋白其他状态

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

2. 结构基本信息 2. Structure Basics

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

5. 晶体学与实验 5. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

6. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 water

7. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

CATH v4.4 (5 domains)

8. 引用文献 (3)

9. 文件与曲线 (10)

Files (7)

Curves (3)