1pcf

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

TRANSCRIPTIONAL COACTIVATOR PC4

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 2	water × 2	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 2	water × 2	Consistent with protein count
3	Protein homooligomer	Homooligomer	Protein 2	water × 2	Consistent with protein count
4	Protein homooligomer	Homooligomer	Protein 2	water × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCP4_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 2–66； UniProt 62–126 Author chain B； PDBConstruct 2–66； UniProt 62–126 Author chain C； PDBConstruct 2–66； UniProt 62–126 Author chain D； PDBConstruct 2–66； UniProt 62–126 Author chain E； PDBConstruct 2–66； UniProt 62–126 Author chain F； PDBConstruct 2–66； UniProt 62–126 Author chain G； PDBConstruct 2–66； UniProt 62–126 Author chain H； PDBConstruct 2–66； UniProt 62–126

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1pcf
Deposition date deposition_date	1997-09-09
Structure title title	HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN
Keywords keywords	TRANSCRIPTION, TRANSCRIPTIONAL COFACTOR, TRANSCRIPTIONAL CO-ACTIVATOR, SSDNA BINDING, NUCLEAR PROTEIN; TRANSCRIPTION
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1pcf__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1pcf__assembly_3__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1pcf__assembly_3__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	16.50 Å
Rg (electron density)	15.17 Å
Total Rg	16.37 Å
Atom count	1090
Residues	132
Excluded volume	19543 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1pcf__assembly_1__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`1pcf__assembly_2__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`1pcf__assembly_3__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
4	1	`1pcf__assembly_4__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (16 domains)

Domain ID domain_id	d1pcfa1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfa2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfb1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfb2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfc1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfc2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfd1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfd2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfe1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfe2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcff1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcff2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfg1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfg2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d1pcfh1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamily	d.18.1 — ssDNA-binding transcriptional regulator domain
Family Family family	d.18.1.1 — Transcriptional coactivator PC4 C-terminal domain

Domain ID domain_id	d1pcfh2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

CATH v4.4 (8 domains)

Domain ID domain_id	1pcfA00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfB00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfC00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfD00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfE00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfF00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfG00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

Domain ID domain_id	1pcfH00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily	10 — Transcriptional Coactivator Pc4; Chain A

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Unit-cell length a length_a	41.283 Å
Unit-cell length b length_b	67.814 Å
Unit-cell length c length_c	67.170 Å
Unit-cell angle α angle_alpha	87.69 °
Unit-cell angle β angle_beta	84.37 °
Unit-cell angle γ angle_gamma	85.79 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	1.740 Å
Low-resolution limit resolution_low	20.000 Å
R factor r_factor	—
R_work r_work	0.1970
R_free r_free	0.2330

Description description	TRANSCRIPTIONAL COACTIVATOR PC4
Molecular weight formula_weight	7784.0 kDa
Source method src_method	man
Copy count entity_count	8

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H
Atom count atom_count	4794

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

1. Protein Identity and Related Structures Protein Identity & Related Structures

TRANSCRIPTIONAL COACTIVATOR PC4

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1pcf__assembly_3__model_1

1pcf__assembly_3__model_1 | I(q)

1pcf__assembly_3__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (16 domains)

CATH v4.4 (8 domains)

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli BL21(DE3)

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	434

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

1. Protein Identity and Related Structures Protein Identity & Related Structures

TRANSCRIPTIONAL COACTIVATOR PC4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1pcf__assembly_3__model_1

1pcf__assembly_3__model_1 | I(q)

1pcf__assembly_3__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (16 domains)

CATH v4.4 (8 domains)

7. Citations (1)