1qki

X-RAY STRUCTURE OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE (VARIANT CANTON R459L) COMPLEXED WITH STRUCTURAL NADP+

Method: X-RAY DIFFRACTION Dmax: 183.6 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 1qki

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1qki
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1qki
沉积日期 deposition_date1999-07-20
结构标题 titleX-RAY STRUCTURE OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE (VARIANT CANTON R459L) COMPLEXED WITH STRUCTURAL NADP+
关键词 keywordsOXIDOREDUCTASE, OXIDOREDUTASE, (CHOH(D)-NADP), GLUCOSE METABOLISM; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier56.08
回转半径 Rg (电子) rg_electron55.74
零角强度 I(0) i02887630000.00
分子量 molecular_weight448770.0 kDa
排除体积 excluded_volume559620 ų
包络体积 envelope_volume799150 ų
水化壳体积 shell_volume116050 ų
包络直径 envelope_diameter191.6
壳层 Rg shell_rg62.11
包络 Rg envelope_rg54.43
形状 Rg shape_rg55.79
总 Rg total_rg55.70
总原子数 total_atoms31608
残基数 n_residues3912
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax183.6
Rg (实空间) rg_real55.97
Rg 误差 (实空间) rg_real_error1.62
I(0) (实空间) i0_real2.8880e+09
I(0) 误差 (实空间) i0_real_error6.3030e+07
Rg (倒空间) rg_reciprocal56.16
I(0) (倒空间) i0_reciprocal2888000000.0000
解质量估计 total_estimate0.8757
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks1
主峰位置 r_peak_primary65.6
偏度 Skewness skewness0.270
峰度 Kurtosis kurtosis-0.322
角度范围 angular_range— – 0.1400 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha205400000.0000
实空间数据点数 n_real_points29
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.894; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.986; Smooth: 0.711

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (5)

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd1qkia1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkia2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkib1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkib2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkic1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkic2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkid1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkid2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkie1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkie2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkif1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkif2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkig1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkig2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like
结构域编号 domain_idd1qkih1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.3 — Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
结构域编号 domain_idd1qkih2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.81 — FwdE/GAPDH domain-like
超家族 Superfamily superfamilyd.81.1 — Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
家族 Family familyd.81.1.5 — Glucose 6-phosphate dehydrogenase-like

CATH v4.4 (16 domains)

结构域编号 domain_id1qkiA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiB01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiB02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiC01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiC02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiD01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiD02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiE01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiE02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiF01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiF02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiG01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiG02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2
结构域编号 domain_id1qkiH01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1qkiH02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology360 — Dihydrodipicolinate Reductase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Dihydrodipicolinate Reductase; domain 2

7. 引用文献 (2)

8. 文件与曲线 (10)