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1r7i

HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Pseudomonas mevalonii

UniProt P13702

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 3 GLYCEROL × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 6 SULFATE ION × 9 GLYCEROL × 6 water × 6 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 4 SULFATE ION × 6 GLYCEROL × 4 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1qay 1r31 1r7i 1t02 4i4b 4i56 4i64 4i6a 4i6w 4i6y 8gdn 8sz6

16 assemblies; showing the first 12

Homotetramer
1r31 1r7i

2 assemblies

Other homooligomers
1qay 1r31 1r7i 1t02

4 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name MVAA_PSEMV
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–428； UniProt 1–428 Author chain B； PDBConstruct 1–428； UniProt 1–428

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1r7i
Deposition date deposition_date2003-10-21
Structure title titleHMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.
Keywords keywords4-ELECTRON OXIDO-REDUCTASE, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1r7i__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1r7i__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1r7i__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）36.05 Å
Rg (electron density)35.50 Å
Total Rg35.87 Å
Atom count11140
Residues1494
Excluded volume198360 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1r7i__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1r7i__assembly_2__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1r7i__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd1r7ia1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.20 — NAD-binding domain of HMG-CoA reductase
Family Family familyd.58.20.1 — NAD-binding domain of HMG-CoA reductase
Domain ID domain_idd1r7ia2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.179 — Substrate-binding domain of HMG-CoA reductase
Superfamily Superfamily superfamilyd.179.1 — Substrate-binding domain of HMG-CoA reductase
Family Family familyd.179.1.1 — Substrate-binding domain of HMG-CoA reductase
Domain ID domain_idd1r7ib1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.20 — NAD-binding domain of HMG-CoA reductase
Family Family familyd.58.20.1 — NAD-binding domain of HMG-CoA reductase
Domain ID domain_idd1r7ib2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.179 — Substrate-binding domain of HMG-CoA reductase
Superfamily Superfamily superfamilyd.179.1 — Substrate-binding domain of HMG-CoA reductase
Family Family familyd.179.1.1 — Substrate-binding domain of HMG-CoA reductase

CATH v4.4 (4 domains)

Domain ID domain_id1r7iA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily420 — Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Domain ID domain_id1r7iA02
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology770 — 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Domain ID domain_id1r7iB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily420 — Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Domain ID domain_id1r7iB02
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology770 — 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
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7. Citations (1)