1ur9
Interactions of a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 1ur9 |
| 沉积日期 deposition_date | 2003-10-27 |
| 结构标题 title | Interactions of a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone |
| 关键词 keywords | HYDROLASE, CHITINASE, INHIBITION, LACTONE, CHITIN DEGRADATION, GLYCOSIDASE; HYDROLASE |
| 实验方法 method | X-RAY DIFFRACTION |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 36.91 Å |
| 回转半径 Rg (电子) rg_electron | 36.42 Å |
| 零角强度 I(0) i0 | 215637000.00 |
| 分子量 molecular_weight | 118260.0 kDa |
| 排除体积 excluded_volume | 147310 ų |
| 包络体积 envelope_volume | 177270 ų |
| 水化壳体积 shell_volume | 41374 ų |
| 包络直径 envelope_diameter | 122.3 Å |
| 壳层 Rg shell_rg | 41.78 Å |
| 包络 Rg envelope_rg | 36.25 Å |
| 形状 Rg shape_rg | 36.37 Å |
| 总 Rg total_rg | 36.89 Å |
| 总原子数 total_atoms | 8310 |
| 残基数 n_residues | 994 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 120.8 Å |
| Rg (实空间) rg_real | 37.14 Å |
| Rg 误差 (实空间) rg_real_error | 0.84 Å |
| I(0) (实空间) i0_real | 2.1560e+08 |
| I(0) 误差 (实空间) i0_real_error | 3.4900e+06 |
| Rg (倒空间) rg_reciprocal | 37.00 Å |
| I(0) (倒空间) i0_reciprocal | 215600000.0000 |
| 解质量估计 total_estimate | 0.8270 |
| 解质量评级 solution_quality | GOOD a GOOD solution |
| P(r) 峰数 n_peaks | 1 |
| 主峰位置 r_peak_primary | 33.7 Å |
| 偏度 Skewness skewness | 0.405 |
| 峰度 Kurtosis kurtosis | -0.716 |
| 角度范围 angular_range | — – 0.2150 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 48590000.0000 |
| 实空间数据点数 n_real_points | 44 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.722; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.790; Smooth: 0.790 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (6)
6. 折叠分类 (SCOP + CATH) 12 domains
SCOP 2.08 (6 domains)
| 结构域编号 domain_id | d1ur9a1 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.72 — WW domain-like |
| 超家族 Superfamily superfamily | b.72.2 — Carbohydrate binding domain |
| 家族 Family family | b.72.2.1 — Carbohydrate binding domain |
| 结构域编号 domain_id | d1ur9a2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.1 — TIM beta/alpha-barrel |
| 超家族 Superfamily superfamily | c.1.8 — (Trans)glycosidases |
| 家族 Family family | c.1.8.5 — Type II chitinase |
| 结构域编号 domain_id | d1ur9a3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.26 — FKBP-like |
| 超家族 Superfamily superfamily | d.26.3 — Chitinase insertion domain |
| 家族 Family family | d.26.3.1 — Chitinase insertion domain |
| 结构域编号 domain_id | d1ur9b1 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.72 — WW domain-like |
| 超家族 Superfamily superfamily | b.72.2 — Carbohydrate binding domain |
| 家族 Family family | b.72.2.1 — Carbohydrate binding domain |
| 结构域编号 domain_id | d1ur9b2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.1 — TIM beta/alpha-barrel |
| 超家族 Superfamily superfamily | c.1.8 — (Trans)glycosidases |
| 家族 Family family | c.1.8.5 — Type II chitinase |
| 结构域编号 domain_id | d1ur9b3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.26 — FKBP-like |
| 超家族 Superfamily superfamily | d.26.3 — Chitinase insertion domain |
| 家族 Family family | d.26.3.1 — Chitinase insertion domain |
CATH v4.4 (6 domains)
| 结构域编号 domain_id | 1ur9A01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 20 — Alpha-Beta Barrel |
| 拓扑 Topology topology | 20 — TIM Barrel |
| 同源超家族 H-superfamily homologous superfamily | 80 — Glycosidases |
| 结构域编号 domain_id | 1ur9A02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 10 — Roll |
| 拓扑 Topology topology | 50 — Chitinase A; domain 3 |
| 同源超家族 H-superfamily homologous superfamily | 10 — |
| 结构域编号 domain_id | 1ur9A03 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 10 — Ribbon |
| 拓扑 Topology topology | 10 — Seminal Fluid Protein PDC-109 (Domain B) |
| 同源超家族 H-superfamily homologous superfamily | 20 — Carbohydrate-binding module superfamily 5/12 |
| 结构域编号 domain_id | 1ur9B01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 20 — Alpha-Beta Barrel |
| 拓扑 Topology topology | 20 — TIM Barrel |
| 同源超家族 H-superfamily homologous superfamily | 80 — Glycosidases |
| 结构域编号 domain_id | 1ur9B02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 10 — Roll |
| 拓扑 Topology topology | 50 — Chitinase A; domain 3 |
| 同源超家族 H-superfamily homologous superfamily | 10 — |
| 结构域编号 domain_id | 1ur9B03 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 10 — Ribbon |
| 拓扑 Topology topology | 10 — Seminal Fluid Protein PDC-109 (Domain B) |
| 同源超家族 H-superfamily homologous superfamily | 20 — Carbohydrate-binding module superfamily 5/12 |