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Structure of an activated Dictyostelium STAT in its DNA-unbound form
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 1uur |
| 沉积日期 deposition_date | 2004-01-09 |
| 结构标题 title | Structure of an activated Dictyostelium STAT in its DNA-unbound form |
| 关键词 keywords | TRANSCRIPTION ACTIVATOR, DICTYOSTELIUM, STAT, SH2, SIGNAL TRANSDUCTION, TRANSDUCER, TRANSCRIPTION FACTOR; TRANSCRIPTION ACTIVATOR |
| 实验方法 method | X-RAY DIFFRACTION |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 29.05 Å |
| 回转半径 Rg (电子) rg_electron | 28.40 Å |
| 零角强度 I(0) i0 | 42343400.00 |
| 分子量 molecular_weight | 51558.0 kDa |
| 排除体积 excluded_volume | 64940 ų |
| 包络体积 envelope_volume | 83340 ų |
| 水化壳体积 shell_volume | 26329 ų |
| 包络直径 envelope_diameter | 118.8 Å |
| 壳层 Rg shell_rg | 32.94 Å |
| 包络 Rg envelope_rg | 29.12 Å |
| 形状 Rg shape_rg | 28.37 Å |
| 总 Rg total_rg | 29.00 Å |
| 总原子数 total_atoms | 3637 |
| 残基数 n_residues | 460 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 115.2 Å |
| Rg (实空间) rg_real | 29.34 Å |
| Rg 误差 (实空间) rg_real_error | 1.35 Å |
| I(0) (实空间) i0_real | 4.2340e+07 |
| I(0) 误差 (实空间) i0_real_error | 6.7310e+05 |
| Rg (倒空间) rg_reciprocal | 29.22 Å |
| I(0) (倒空间) i0_reciprocal | 42340000.0000 |
| 解质量估计 total_estimate | 0.7431 |
| 解质量评级 solution_quality | REASONABLE a REASONABLE solution |
| P(r) 峰数 n_peaks | 2 |
| 主峰位置 r_peak_primary | 27.2 Å |
| 偏度 Skewness skewness | 0.659 |
| 峰度 Kurtosis kurtosis | 0.118 |
| 角度范围 angular_range | — – 0.2750 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 11150000.0000 |
| 实空间数据点数 n_real_points | 56 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.447; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.324; Smooth: 0.991 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (2)
6. 折叠分类 (SCOP + CATH) 7 domains
SCOP 2.08 (3 domains)
| 结构域编号 domain_id | d1uura1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.47 — STAT-like |
| 超家族 Superfamily superfamily | a.47.1 — STAT |
| 家族 Family family | a.47.1.1 — STAT |
| 结构域编号 domain_id | d1uura2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.2 — Common fold of diphtheria toxin/transcription factors/cytochrome f |
| 超家族 Superfamily superfamily | b.2.5 — p53-like transcription factors |
| 家族 Family family | b.2.5.5 — STAT DNA-binding domain |
| 结构域编号 domain_id | d1uura3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.93 — SH2-like |
| 超家族 Superfamily superfamily | d.93.1 — SH2 domain |
| 家族 Family family | d.93.1.1 — SH2 domain |
CATH v4.4 (4 domains)
| 结构域编号 domain_id | 1uurA01 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 20 — Up-down Bundle |
| 拓扑 Topology topology | 58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 240 — STAT; domain 1 |
| 结构域编号 domain_id | 1uurA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 340 — Rel homology domain (RHD), DNA-binding domain |
| 结构域编号 domain_id | 1uurA03 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 238 — Recoverin; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — EF-hand |
| 结构域编号 domain_id | 1uurA04 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 505 — SHC Adaptor Protein |
| 同源超家族 H-superfamily homologous superfamily | 10 — SH2 domain |