1wpl

Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP cyclohydrolase I

Rattus norvegicus

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 20	GTP cyclohydrolase I feedback regulatory protein × 10 （P70552） ZINC ION × 10 7,8-DIHYDROBIOPTERIN × 10 TRIPHOSPHATE × 10 SODIUM ION × 10 water × 20	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	GCH1_RAT
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–230； UniProt 12–241 作者链 B； PDB构建体 1–230； UniProt 12–241 作者链 C； PDB构建体 1–230； UniProt 12–241 作者链 D； PDB构建体 1–230； UniProt 12–241 作者链 E； PDB构建体 1–230； UniProt 12–241 作者链 F； PDB构建体 1–230； UniProt 12–241 作者链 G； PDB构建体 1–230； UniProt 12–241 作者链 H； PDB构建体 1–230； UniProt 12–241 作者链 I； PDB构建体 1–230； UniProt 12–241 作者链 J； PDB构建体 1–230； UniProt 12–241

GTP cyclohydrolase I feedback regulatory protein

Rattus norvegicus

UniProt P70552

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 20	GTP cyclohydrolase I × 10 （P22288） ZINC ION × 10 7,8-DIHYDROBIOPTERIN × 10 TRIPHOSPHATE × 10 SODIUM ION × 10 water × 20	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	GFRP_RAT
Isoform	—
PDB实体	2
链与序列区间	作者链 K； PDB构建体 1–84； UniProt 0–83 作者链 L； PDB构建体 1–84； UniProt 0–83 作者链 M； PDB构建体 1–84； UniProt 0–83 作者链 N； PDB构建体 1–84； UniProt 0–83 作者链 O； PDB构建体 1–84； UniProt 0–83 作者链 P； PDB构建体 1–84； UniProt 0–83 作者链 Q； PDB构建体 1–84； UniProt 0–83 作者链 R； PDB构建体 1–84； UniProt 0–83 作者链 S； PDB构建体 1–84； UniProt 0–83 作者链 T； PDB构建体 1–84； UniProt 0–83

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1wpl
沉积日期 deposition_date	2004-09-08
结构标题 title	Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex
关键词 keywords	ENZYME-REGULATORY PROTEIN COMPLEX, HYDROLASE-PROTEIN BINDING COMPLEX; HYDROLASE/PROTEIN BINDING
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1wpl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1wpl__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1wpl__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	42.33 Å
Rg（电子密度）	41.72 Å
总 Rg	41.93 Å
原子数	22420
残基数	2780
排除体积	400070 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1wpl__assembly_1__model_1`	eicosameric （20）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

描述 description	GTP cyclohydrolase I
分子量 formula_weight	25819.7 kDa
EC 编号 ec_number	3.5.4.16
来源方法 src_method	man
拷贝数 entity_count	10

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J
原子数 atom_count	22650

GFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

来源 Source

来源生物 organism	Rattus norvegicus
通用名 common_name	Norway rat
NCBI 分类编号 ncbi_taxonomy_id	10116
宿主生物 host_organism	Escherichia coli

实体 2 Entity 2 polymer

描述 description	GTP cyclohydrolase I feedback regulatory protein
分子量 formula_weight	9683.2 kDa
来源方法 src_method	man
拷贝数 entity_count	10

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	K,L,M,N,O,P,Q,R,S,T

MPYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNFYEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWCLHKE

来源 Source

来源生物 organism	Rattus norvegicus
通用名 common_name	Norway rat
NCBI 分类编号 ncbi_taxonomy_id	10116
宿主生物 host_organism	Escherichia coli

实体 3 Entity 3 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 4 Entity 4 non-polymer

描述 description	7,8-DIHYDROBIOPTERIN
分子量 formula_weight	239.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 5 Entity 5 non-polymer

描述 description	TRIPHOSPHATE
分子量 formula_weight	258.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 6 Entity 6 non-polymer

描述 description	SODIUM ION
分子量 formula_weight	23.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	10

实体 7 Entity 7 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	230

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6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

结构域编号 domain_id	d1wpla_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplb_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplc_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wpld_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wple_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplf_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplg_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplh_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wpli_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplj_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.96 — T-fold
超家族 Superfamily superfamily	d.96.1 — Tetrahydrobiopterin biosynthesis enzymes-like
家族 Family family	d.96.1.1 — GTP cyclohydrolase I

结构域编号 domain_id	d1wplk_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wpll_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplm_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wpln_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplo_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplp_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplq_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplr_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wpls_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

结构域编号 domain_id	d1wplt_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
超家族 Superfamily superfamily	d.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
家族 Family family	d.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP

CATH v4.4 (30 domains)

结构域编号 domain_id	1wplA01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplA02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplB01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplB02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplC01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplC02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplD01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplD02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplE01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplE02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplF01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplF02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplG01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplG02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplH01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplH02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplI01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplI02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplJ01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	286 — GTP Cyclohydrolase I; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, N-terminal domain

结构域编号 domain_id	1wplJ02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1130 — GTP Cyclohydrolase I, domain 2
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

结构域编号 domain_id	1wplK00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplL00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplM00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplN00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplO00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplP00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplQ00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplR00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplS00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

结构域编号 domain_id	1wplT00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1410 — Gtp Cyclohydrolase I Feedback Regulatory Protein; Chain: K
同源超家族 H-superfamily homologous superfamily	10 — GTP cyclohydrolase I feedback regulatory protein GFRP

▶

晶胞边长 a length_a	121.720 Å
晶胞边长 b length_b	109.670 Å
晶胞边长 c length_c	130.270 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	97.85 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	20

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.800 Å
最低分辨率 resolution_low	15.000 Å
R 因子 r_factor	—
R_work r_work	0.2069
R_free r_free	0.2328

Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex

1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP cyclohydrolase I

当前结构中的状态

数据库中的同蛋白其他状态

GTP cyclohydrolase I feedback regulatory protein

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1wpl__assembly_1__model_1

1wpl__assembly_1__model_1 | I(q)

1wpl__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. 引用文献 (1)

Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex

1. 蛋白身份与相关结构 Protein Identity & Related Structures

GTP cyclohydrolase I

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

GTP cyclohydrolase I feedback regulatory protein

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1wpl__assembly_1__model_1

1wpl__assembly_1__model_1 | I(q)

1wpl__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. 引用文献 (1)