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1xpx

Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protein prospero

Drosophila melanogaster

UniProt P29617

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 2 5'-D(*AP*GP*CP*AP*TP*GP*CP*CP*TP*G)-3' × 1 5'-D(*CP*AP*GP*GP*CP*AP*TP*GP*CP*T)-3' × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1mij

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1xpx

1 assemblies

View Construct and Data Evidence
UniProt name PROS_DROME
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–163； UniProt 1241–1403

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1xpx
Deposition date deposition_date2004-10-09
Structure title titleStructural basis of prospero-DNA interaction; implications for transcription regulation in developing cells
Keywords keywordshomeodomain, protein-DNA binding, prospero, neural cell development, TRANSCRIPTION REGULATION-DNA COMPLEX; TRANSCRIPTION REGULATION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1xpx__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1xpx__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1xpx__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.78 Å
Rg (electron density)17.61 Å
Total Rg18.59 Å
Atom count1644
Residues164
Excluded volume28080 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1xpx__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1xpxa_
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.1 — Homeodomain-like
Family Family familya.4.1.1 — Homeodomain

CATH v4.4 (1 domains)

Domain ID domain_id1xpxA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily500 — Homeo-prospero domain
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7. Citations (2)