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1z2c

Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Rho-related GTP-binding protein RhoC

Homo sapiens

UniProt P08134

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Diaphanous protein homolog 1 × 2 （O08808） MAGNESIUM ION × 4 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Diaphanous protein homolog 1 × 2 （O08808） MAGNESIUM ION × 2 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2gcn 2gco 2gco 2gcp

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1z2c 1z2c

2 assemblies

View Construct and Data Evidence
UniProt name RHOC_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–193； UniProt 1–193 Author chain C； PDBConstruct 1–193； UniProt 1–193

Diaphanous protein homolog 1

Mus musculus

UniProt O08808

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Rho-related GTP-binding protein RhoC × 2 （P08134） MAGNESIUM ION × 4 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Rho-related GTP-binding protein RhoC × 2 （P08134） MAGNESIUM ION × 2 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
2bnx 2f31

2 assemblies

Homotetramer
1v9d 2bap 2bap 2f31 3o4x 3o4x

6 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1z2c 1z2c 2v8f 3eg5 3obv 3obv 4uwx 4uwx 8ru2 9b27 9b3d

11 assemblies

View Construct and Data Evidence
UniProt name DIAP1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–383； UniProt 69–451 Author chain D； PDBConstruct 1–383； UniProt 69–451

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1z2c
Deposition date deposition_date2005-03-08
Structure title titleCrystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
Keywords keywordsarmadillo repeat, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1z2c__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1z2c__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1z2c__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）39.60 Å
Rg (electron density)39.93 Å
Total Rg39.95 Å
Atom count8482
Residues1050
Excluded volume151330 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1z2c__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1z2c__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 12 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd1z2ca1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1z2cb1
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.23 — Diap1 N-terninal region-like
Domain ID domain_idd1z2cc_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1z2cd_
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.23 — Diap1 N-terninal region-like

CATH v4.4 (8 domains)

Domain ID domain_id1z2cA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1z2cB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily40 — Formin, diaphanous GTPase-binding domain
Domain ID domain_id1z2cB02
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id1z2cB03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily150 — Formin, FH3 diaphanous domain
Domain ID domain_id1z2cC00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1z2cD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily40 — Formin, diaphanous GTPase-binding domain
Domain ID domain_id1z2cD02
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id1z2cD03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily150 — Formin, FH3 diaphanous domain
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7. Citations (2)