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1zzf

The DNA-bound solution structure of HPV-16 E2 DNA-binding domain

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Regulatory protein E2

Human papillomavirus type 16

UniProt P03120

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1by9 1dto 1r8p 1zzf 2q79 3mi7

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2nnu 2nnu

2 assemblies

View Construct and Data Evidence
UniProt name VE2_HPV16
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–81； UniProt 286–365 Author chain B； PDBConstruct 2–81； UniProt 286–365

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1zzf
Deposition date deposition_date2005-06-14
Structure title titleThe DNA-bound solution structure of HPV-16 E2 DNA-binding domain
Keywords keywordsdna-protein complex, papillomavirus transcription factor, dimeric beta-barrel, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1zzf__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1zzf__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1zzf__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.54 Å
Rg (electron density)16.44 Å
Total Rg17.59 Å
Atom count2664
Residues162
Excluded volume23758 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1zzf__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1zzfa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.8 — Viral DNA-binding domain
Family Family familyd.58.8.1 — Viral DNA-binding domain
Domain ID domain_idd1zzfb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.8 — Viral DNA-binding domain
Family Family familyd.58.8.1 — Viral DNA-binding domain

CATH v4.4 (2 domains)

Domain ID domain_id1zzfA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
Domain ID domain_id1zzfB00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
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7. Citations (1)