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22be

XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1

Method: ELECTRON MICROSCOPY Dmax: 111.0 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Potassium voltage-gated channel subfamily KQT member 3

Homo sapiens

UniProt O43525

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain A； UniProt 1–872 Not recorded Potassium voltage-gated channel subfamily KQT member 2 × 3 （O43526） POTASSIUM ION × 3 Azetukalner × 4 ELECTRON MICROSCOPY mmCIF provides none of the parsed experimental conditions Resolution 2.60 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 22BE Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
22AZ ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.70 Å
22BA ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.90 Å
22BC ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.80 Å
22BD ICA-1103811 bound KCNQ2/3 heteromer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.00 Å
22BF XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.50 Å
22BG XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.50 Å
22BH XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 4 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.80 Å
22BI XEN1101 bound KCNQ2/3 heteromer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.60 Å
22BJ KCNQ2/3 heterotetramer with 3:1 stoichiometry Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.40 Å
22BK KCNQ2/3 heterotetramer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.70 Å
22RJ Human KCNQ3-CaM in apo state Deposited 2026-01-21 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.82 Å
22RQ Human KCNQ3-XEN1101 complex in the presence of PIP2 Deposited 2026-01-21 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.90 Å
5J03 Crystal Structure of a chimeric Kv7.2 - Kv7.3 proximal C-terminal Domain in Complex with Calmodulin Deposited 2016-03-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 234–289（56 aa）
Not recorded CA CALCIUM ION × 5 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.7；292 K；18% PEG 4K and 100 mM calcium acetate
Resolution 2.00 Å R-free 0.228
9X5J Cryo-EM structure of the human KCNQ2/3 heteromer channel Deposited 2025-10-13 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 103–573（471 aa）
Chain B 103–573（471 aa）
Chain C 103–573（471 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.05 Å
9X65 Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state Deposited 2025-10-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded A1EY8 Azetukalner × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.19 Å

15 other PDB entries and 15 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name KCNQ3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–872； UniProt 1–872

Potassium voltage-gated channel subfamily KQT member 2

Homo sapiens

UniProt O43526

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain B； UniProt 1–872 Chain C； UniProt 1–872 Chain D； UniProt 1–872 Not recorded Potassium voltage-gated channel subfamily KQT member 3 × 1 （O43525） POTASSIUM ION × 3 Azetukalner × 4 ELECTRON MICROSCOPY mmCIF provides none of the parsed experimental conditions Resolution 2.60 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 22BE Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
22AY KCNQ2 homotetramer in apo state Deposited 2026-01-05 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.30 Å
22AZ ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.70 Å
22BA ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.90 Å
22BC ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.80 Å
22BD ICA-1103811 bound KCNQ2/3 heteromer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.00 Å
22BF XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.50 Å
22BG XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.50 Å
22BH XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 4 Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.80 Å
22BI XEN1101 bound KCNQ2/3 heteromer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.60 Å
22BJ KCNQ2/3 heterotetramer with 3:1 stoichiometry Deposited 2026-01-05 Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.40 Å
22BK KCNQ2/3 heterotetramer with 2:2 stoichiometry Deposited 2026-01-05 Different construct Different mutation/modification Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain C 1–872（872 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.70 Å
5J03 Crystal Structure of a chimeric Kv7.2 - Kv7.3 proximal C-terminal Domain in Complex with Calmodulin Deposited 2016-03-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 502–529（28 aa）
Not recorded CA CALCIUM ION × 5 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.7；292 K；18% PEG 4K and 100 mM calcium acetate
Resolution 2.00 Å R-free 0.228
6FEG Solution Structure of CaM/Kv7.2-hAB Complex Deposited 2018-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 326–372（47 aa）
Chain A 502–532（31 aa）
Mutation：Del. R374-K493,Del. R374-K493 Mutation：Del. R374-K493,Del. R374-K493 CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 6；303 K；Ionic strength (raw mmCIF value) 120；Pressure 1
NMR sample composition 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Kv7.2-hAB, 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM [U-100% 13C; U-100% 15N] Kv7.2-hAB, 500 uM Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM Kv7.2-hAB, 500 uM [U-100% 13C; U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 250 uM [U-100% 15N] Kv7.2-hAB, 250 uM [U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6FEH Solution Structure of CaM/Kv7.2-hAB Complex Deposited 2018-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 326–372（47 aa）
Chain A 502–532（31 aa）
Mutation：Del. R374-K493,Del. R374-K493 Mutation：Del. R374-K493,Del. R374-K493 CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 6；303 K；Ionic strength (raw mmCIF value) 120；Pressure 1
NMR sample composition 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Kv7.2-hAB, 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM [U-100% 13C; U-100% 15N] Kv7.2-hAB, 500 uM Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 250 uM [U-100% 15N] Kv7.2-hAB, 250 uM [U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
7CR0 human KCNQ2 in apo state Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7CR1 human KCNQ2 in complex with ztz240 Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded GB9 N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7CR2 human KCNQ2 in complex with retigabine Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded FBX ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
7CR3 human KCNQ2-CaM in apo state Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
7CR4 human KCNQ2-CaM in complex with ztz240 Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain F 64–702（639 aa）
Not recorded GB9 N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7CR7 human KCNQ2-CaM in complex with retigabine Deposited 2020-08-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded FBX ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8IJK human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 Deposited 2023-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded 7PN N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8IZY Human KCNQ2-CaM in complex with HN37 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8J00 Human KCNQ2-CaM in complex with CBD Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain C 64–702（639 aa）
Chain D 64–702（639 aa）
Not recorded P0T cannabidiol × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8J01 Human KCNQ2-CaM in complex with CBD and PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded P0T cannabidiol × 8 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8J02 Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–703（640 aa）
Chain B 64–703（640 aa）
Chain D 64–703（640 aa）
Chain G 64–703（640 aa）
Not recorded P0T cannabidiol × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8J03 Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–703（640 aa）
Chain D 64–703（640 aa）
Chain G 64–703（640 aa）
Chain I 64–703（640 aa）
Not recorded P0T cannabidiol × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8J04 Human KCNQ2-CaM-HN37 complex in the presence of PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8J05 Human KCNQ2-CaM complex in the presence of PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8W4U human KCNQ2-CaM in complex with PIP2 and HN37 Deposited 2023-08-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain B 64–702（639 aa）
Chain D 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8X43 human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 Deposited 2023-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–702（639 aa）
Chain C 64–702（639 aa）
Chain E 64–702（639 aa）
Chain G 64–702（639 aa）
Not recorded 7Q0 N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8XO1 Human KCNQ2-CaM in complex with QO-83 Deposited 2023-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded A1LWZ ~{N}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9IXY Human KCNQ2-CaM-Ebio2 Complex in the Presence of PIP2 Deposited 2024-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–674（611 aa）
Chain B 64–674（611 aa）
Chain C 64–674（611 aa）
Chain D 64–674（611 aa）
Not recorded A1L3C ~{N}-[7-[bis(fluoranyl)methoxy]-1-prop-2-ynyl-indazol-3-yl]-3,3-dimethyl-butanamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9IXZ human KCNQ2-CaM-Ebio3 Complex in the Presence of PIP2 Deposited 2024-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 64–674（611 aa）
Chain B 64–674（611 aa）
Chain C 64–674（611 aa）
Chain D 64–674（611 aa）
Not recorded A1L3D ~{N}-[7-[bis(fluoranyl)methoxy]-1-prop-2-ynyl-indazol-3-yl]-2-propyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9L8W Human KCNQ2-CaM in complex with QO-58 Deposited 2024-12-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded A1LVR QO-58 × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9X5J Cryo-EM structure of the human KCNQ2/3 heteromer channel Deposited 2025-10-13 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 70–594（525 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.05 Å
9X65 Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state Deposited 2025-10-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–872（872 aa）
Not recorded A1EY8 Azetukalner × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.19 Å
9XB9 Human KCNQ2-CaM in complex with QO-58 and PIP2 Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 A1LVR QO-58 × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9XED Human KCNQ2-CaM in complex with QO-83 and PIP2 Deposited 2025-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–872（872 aa）
Chain B 1–872（872 aa）
Chain C 1–872（872 aa）
Chain D 1–872（872 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 A1LWZ ~{N}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å

38 other PDB entries and 38 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name KCNQ2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–872； UniProt 1–872 Author chain C； PDBConstruct 1–872； UniProt 1–872 Author chain D； PDBConstruct 1–872； UniProt 1–872

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 22be

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 22be
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2. Structure Basics 2. Structure Basics

Entry ID entry_id22be
Deposition date deposition_date2026-01-05
Structure title titleXEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1
Keywords keywordsM-channel, KCNQ2/3, heteromeric channel, cryoEM, XEN1101, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier34.39 Å
Radius of gyration Rg (electron density) rg_electron33.56 Å
Forward intensity I(0) i0358071000.00
Molecular weight molecular_weight107240.0 kDa
Excluded volume excluded_volume106780 ų
Envelope volume envelope_volume196900 ų
Hydration-shell volume shell_volume48727 ų
Envelope diameter envelope_diameter117.2 Å
Shell Rg shell_rg40.35 Å
Envelope Rg envelope_rg33.80 Å
Shape Rg shape_rg33.54 Å
Total Rg total_rg34.00 Å
Total atoms total_atoms8191
Residues n_residues996
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax111.0 Å
Rg (real space) rg_real34.29 Å
Rg uncertainty (real space) rg_real_error0.68 Å
I(0) (real space) i0_real3.5810e+08
I(0) uncertainty (real space) i0_real_error5.3930e+06
Rg (reciprocal space) rg_reciprocal34.35 Å
I(0) (reciprocal space) i0_reciprocal358100000.0000
Solution quality estimate total_estimate0.8796
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary45.8 Å
Skewness Skewness skewness0.235
Kurtosis Kurtosis kurtosis-0.272
Angular range angular_range— – 0.2300 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha27850000.0000
Real-space data points n_real_points47
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.855; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.992; Smooth: 0.873
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (4)

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8. Citations (1)

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9. Files and Curves (10)