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2abm

Crystal Structure of Aquaporin Z Tetramer Reveals both Open and Closed Water-conducting Channels

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Aquaporin Z

Escherichia coli

UniProt P60844

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 4 2-O-octyl-beta-D-glucopyranose × 3 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 3 PHOSPHATE ION × 2 3-PHOSPHOGLYCERIC ACID × 1 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 1 water × 4 与蛋白数一致
2 蛋白同源多聚体 同源多聚体 蛋白 4 2-O-octyl-beta-D-glucopyranose × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 PHOSPHATE ION × 2 3-PHOSPHOGLYCERIC ACID × 1 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 1 water × 4 与蛋白数一致
3 蛋白同源多聚体 同源多聚体 蛋白 16 2-O-octyl-beta-D-glucopyranose × 8 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 2 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 PHOSPHATE ION × 8 3-PHOSPHOGLYCERIC ACID × 4 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 4 water × 16 与蛋白数一致
4 蛋白同源多聚体 同源多聚体 蛋白 16 2-O-octyl-beta-D-glucopyranose × 8 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 2 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 PHOSPHATE ION × 8 3-PHOSPHOGLYCERIC ACID × 4 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 4 water × 16 与蛋白数一致
5 蛋白同源多聚体 同源多聚体 蛋白 16 2-O-octyl-beta-D-glucopyranose × 8 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 2 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 PHOSPHATE ION × 8 3-PHOSPHOGLYCERIC ACID × 4 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 4 water × 16 与蛋白数一致
6 蛋白同源多聚体 同源多聚体 蛋白 16 2-O-octyl-beta-D-glucopyranose × 8 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 2 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 PHOSPHATE ION × 8 3-PHOSPHOGLYCERIC ACID × 4 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 4 water × 16 与蛋白数一致
7 蛋白同源多聚体 同源多聚体 蛋白 8 2-O-octyl-beta-D-glucopyranose × 4 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 PHOSPHATE ION × 4 3-PHOSPHOGLYCERIC ACID × 2 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 2 water × 8 与蛋白数一致
8 蛋白同源多聚体 同源多聚体 蛋白 8 2-O-octyl-beta-D-glucopyranose × 4 BIS(((3S,4S,5R,6R)-5-(ETHYL(PHOSPHORYLOXY))-3,4,6-TRIHYDROXY-TETRAHYDRO-2H-PYRAN-2-YL)METHYL) HYDROGEN PHOSPHATE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 PHOSPHATE ION × 4 3-PHOSPHOGLYCERIC ACID × 2 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE × 2 water × 8 与蛋白数一致

数据库中的同蛋白其他状态

单体
1rc2 2o9d 2o9f

共 3 个 assembly

同源二聚体

暂无

同源四聚体
1rc2 1rc2 2abm 2abm 2o9d 2o9d 2o9e 2o9f 2o9f 2o9g 3nk5 3nk5

共 16 个 assembly，这里只显示前 12 个

其他同源多聚体
2abm 2abm 2abm 2abm 2abm 2abm

共 6 个 assembly

异源或核酸复合物
8uy6

共 1 个 assembly

查看构建体与数据证据
UniProt名称 AQPZ_ECOLI
Isoform —
PDB实体 1
链与序列区间 作者链 A； PDB构建体 1–231； UniProt 1–231 作者链 B； PDB构建体 1–231； UniProt 1–231 作者链 C； PDB构建体 1–231； UniProt 1–231 作者链 D； PDB构建体 1–231； UniProt 1–231 作者链 E； PDB构建体 1–231； UniProt 1–231 作者链 F； PDB构建体 1–231； UniProt 1–231 作者链 G； PDB构建体 1–231； UniProt 1–231 作者链 H； PDB构建体 1–231； UniProt 1–231

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2abm
沉积日期 deposition_date2005-07-15
结构标题 titleCrystal Structure of Aquaporin Z Tetramer Reveals both Open and Closed Water-conducting Channels
关键词 keywordsAQUAPORIN, MEMBRANE PROTEIN; MEMBRANE PROTEIN
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2abm__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2abm__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点；横轴和纵轴均采用对数尺度。

2abm__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置，不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg（Guinier）26.87 Å
Rg（电子密度）25.83 Å
总 Rg26.89 Å
原子数6733
残基数908
排除体积122950 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2abm__assembly_1__model_1 tetrameric （4） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2abm__assembly_2__model_1 tetrameric （4） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2abm__assembly_3__model_1 hexadecameric （16） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 2abm__assembly_4__model_1 hexadecameric （16） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 2abm__assembly_5__model_1 hexadecameric （16） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 2abm__assembly_6__model_1 hexadecameric （16） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 1 2abm__assembly_7__model_1 octameric （8） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 1 2abm__assembly_8__model_1 octameric （8） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (8)

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6. 折叠分类 (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

结构域编号 domain_idd2abma1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmb1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmc1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmd1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abme1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmf1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmg1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like
结构域编号 domain_idd2abmh1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.19 — Aquaporin-like
超家族 Superfamily superfamilyf.19.1 — Aquaporin-like
家族 Family familyf.19.1.1 — Aquaporin-like

CATH v4.4 (8 domains)

结构域编号 domain_id2abmA00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmB00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmE00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmF00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmG00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
结构域编号 domain_id2abmH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1080 — Glycerol uptake facilitator protein
同源超家族 H-superfamily homologous superfamily10 — Glycerol uptake facilitator protein.
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7. 引用文献 (1)