2b76

E. coli Quinol fumarate reductase FrdA E49Q mutation

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Fumarate reductase iron-sulfur protein

Escherichia coli

UniProt P00364

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase subunit C × 1 (P0A8Q0) Fumarate reductase subunit D × 1 (P0A8Q3) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase subunit C × 1 (P0A8Q0) Fumarate reductase subunit D × 1 (P0A8Q3) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FRDB_ECOLI
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–243; UniProt 1–243 作者链 N; PDB构建体 1–243; UniProt 1–243

Fumarate reductase subunit C

Escherichia coli

UniProt P0A8Q0

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase iron-sulfur protein × 1 (P00364) Fumarate reductase subunit D × 1 (P0A8Q3) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase iron-sulfur protein × 1 (P00364) Fumarate reductase subunit D × 1 (P0A8Q3) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FRDC_ECOLI
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–130; UniProt 2–131 作者链 O; PDB构建体 1–130; UniProt 2–131

Fumarate reductase subunit D

Escherichia coli

UniProt P0A8Q3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase iron-sulfur protein × 1 (P00364) Fumarate reductase subunit C × 1 (P0A8Q0) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 Fumarate reductase flavoprotein subunit × 1 Fumarate reductase iron-sulfur protein × 1 (P00364) Fumarate reductase subunit C × 1 (P0A8Q0) CITRATE ANION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 FE3-S4 CLUSTER × 1 IRON/SULFUR CLUSTER × 1 MENAQUINONE-7 × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FRDD_ECOLI
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–119; UniProt 1–119 作者链 P; PDB构建体 1–119; UniProt 1–119

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2b76
沉积日期 deposition_date2005-10-03
结构标题 titleE. coli Quinol fumarate reductase FrdA E49Q mutation
关键词 keywordsfumarate reductase, succinate dehydrogenase, electron transfer, respiration, krebs cycle, membrane protein, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2b76__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2b76__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2b76__assembly_2__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)32.66 Å
Rg(电子密度)33.38 Å
总 Rg33.48 Å
原子数8403
残基数1064
排除体积150100 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2b76__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2b76__assembly_2__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (10)

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6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (14 domains)

结构域编号 domain_idd2b76a1
类 Class classa — All alpha proteins
折叠类型 Fold folda.7 — Spectrin repeat-like
超家族 Superfamily superfamilya.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family familya.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
结构域编号 domain_idd2b76a2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamilyc.3.1 — FAD/NAD(P)-binding domain
家族 Family familyc.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain
结构域编号 domain_idd2b76a3
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamilyd.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family familyd.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_idd2b76b1
类 Class classa — All alpha proteins
折叠类型 Fold folda.1 — Globin-like
超家族 Superfamily superfamilya.1.2 — alpha-helical ferredoxin
家族 Family familya.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
结构域编号 domain_idd2b76b2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.4 — 2Fe-2S ferredoxin-like
家族 Family familyd.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins
结构域编号 domain_idd2b76c1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2b76d1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2b76m1
类 Class classa — All alpha proteins
折叠类型 Fold folda.7 — Spectrin repeat-like
超家族 Superfamily superfamilya.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family familya.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
结构域编号 domain_idd2b76m2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamilyc.3.1 — FAD/NAD(P)-binding domain
家族 Family familyc.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain
结构域编号 domain_idd2b76m3
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamilyd.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family familyd.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_idd2b76n1
类 Class classa — All alpha proteins
折叠类型 Fold folda.1 — Globin-like
超家族 Superfamily superfamilya.1.2 — alpha-helical ferredoxin
家族 Family familya.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
结构域编号 domain_idd2b76n2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.4 — 2Fe-2S ferredoxin-like
家族 Family familyd.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins
结构域编号 domain_idd2b76o1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2b76p1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

CATH v4.4 (16 domains)

结构域编号 domain_id2b76A01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2b76A02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2b76A03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2b76A04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2b76B01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2b76B02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2b76C00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2b76D00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2b76M01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2b76M02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2b76M03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2b76M04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2b76N01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2b76N02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2b76O00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2b76P00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
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7. 引用文献 (1)