2c4k

Crystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39)

Method: X-RAY DIFFRACTION Dmax: 145.9 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

SAXS profile for 2c4k

P(r) 距离分布 P(r) Distribution

P(r) distribution for 2c4k
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id2c4k
沉积日期 deposition_date2005-10-20
结构标题 titleCrystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39)
关键词 keywordsNUCLEOTIDE BIOSYNTHESIS, SYNTHETASE, LIGASE, REGULATORY PROTEIN; REGULATORY PROTEIN
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier45.81
回转半径 Rg (电子) rg_electron45.19
零角强度 I(0) i0575624000.00
分子量 molecular_weight203740.0 kDa
排除体积 excluded_volume257770 ų
包络体积 envelope_volume357400 ų
水化壳体积 shell_volume64389 ų
包络直径 envelope_diameter147.2
壳层 Rg shell_rg52.15
包络 Rg envelope_rg43.77
形状 Rg shape_rg45.18
总 Rg total_rg45.53
总原子数 total_atoms14302
残基数 n_residues1830
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax145.9
Rg (实空间) rg_real45.69
Rg 误差 (实空间) rg_real_error1.50
I(0) (实空间) i0_real5.7560e+08
I(0) 误差 (实空间) i0_real_error1.0410e+07
Rg (倒空间) rg_reciprocal45.81
I(0) (倒空间) i0_reciprocal575700000.0000
解质量估计 total_estimate0.8898
解质量评级 solution_quality GOOD a GOOD solution
P(r) 峰数 n_peaks1
主峰位置 r_peak_primary55.8
偏度 Skewness skewness0.156
峰度 Kurtosis kurtosis-0.593
角度范围 angular_range— – 0.1700 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha39950000.0000
实空间数据点数 n_real_points35
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.951; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.998; Smooth: 0.710

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (4)

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

结构域编号 domain_idd2c4ka1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4ka2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kb1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kb2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kc1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kc2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kd1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kd2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4ke1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4ke2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kf1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like
结构域编号 domain_idd2c4kf2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.61 — PRTase-like
超家族 Superfamily superfamilyc.61.1 — PRTase-like
家族 Family familyc.61.1.2 — Phosphoribosylpyrophosphate synthetase-like

CATH v4.4 (12 domains)

结构域编号 domain_id2c4kA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kA02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kB01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kB02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kC01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kC02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kD01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kD02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kE01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kE02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kF01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020
结构域编号 domain_id2c4kF02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily2020

7. 引用文献 (1)

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