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2ch4

Complex between Bacterial Chemotaxis histidine kinase CheA domains P4 and P5 and receptor-adaptor protein CheW

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CHEMOTAXIS PROTEIN CHEA

THERMOTOGA MARITIMA

UniProt Q56310

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 CHEMOTAXIS PROTEIN CHEW × 1 （Q56311） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 CHEMOTAXIS PROTEIN CHEW × 1 （Q56311） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1i5d 1tqg 2ld6 6mi6 6mi6 6mi6 6mi6 8oyq 8oyq 8oyz 8oyz 8oz9

17 assemblies; showing the first 12

Homodimer
1b3q 1i58 1i59 1i5a 1i5b 1i5c 4xiv 8oyz 8p3n 8p3r

10 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1u0s 2ch4 2ch4 3ur1 4jpb

5 assemblies

View Construct and Data Evidence
UniProt name CHEA_THEMA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–320； UniProt 355–671 Author chain B； PDBConstruct 4–320； UniProt 355–671

CHEMOTAXIS PROTEIN CHEW

THERMOTOGA MARITIMA

UniProt Q56311

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 CHEMOTAXIS PROTEIN CHEA × 1 （Q56310） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 CHEMOTAXIS PROTEIN CHEA × 1 （Q56310） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1k0s

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ch4 2ch4 3ur1 4jpb

4 assemblies

View Construct and Data Evidence
UniProt name CHEW_THEMA
Isoform —
PDB entities 2
Chains and sequence ranges Author chain W； PDBConstruct 1–151； UniProt 1–151 Author chain Y； PDBConstruct 1–151； UniProt 1–151

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2ch4
Deposition date deposition_date2006-03-10
Structure title titleComplex between Bacterial Chemotaxis histidine kinase CheA domains P4 and P5 and receptor-adaptor protein CheW
Keywords keywords;TRANSFERASE/CHEMOTAXIS, CHEMOTAXIS, PROTEIN-PROTEIN COMPLEX, SIGNAL TRANSDUCTION, HISTIDINE KINASE, SENSORY TRANSDUCTION, PHOSPHORYLATION, TRANSFERASE, TRANSFERASE-CHEMOTAXIS complex ;; TRANSFERASE/CHEMOTAXIS
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2ch4__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2ch4__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2ch4__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.48 Å
Rg (electron density)26.56 Å
Total Rg27.30 Å
Atom count3596
Residues459
Excluded volume64784 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2ch4__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2ch4__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 18 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd2ch4a1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.7 — CheW-like
Family Family familyb.40.7.1 — CheW-like
Domain ID domain_idd2ch4a2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.122 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily Superfamily superfamilyd.122.1 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family Family familyd.122.1.3 — Histidine kinase
Domain ID domain_idd2ch4a3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2ch4b1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.7 — CheW-like
Family Family familyb.40.7.1 — CheW-like
Domain ID domain_idd2ch4b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.122 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily Superfamily superfamilyd.122.1 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family Family familyd.122.1.3 — Histidine kinase
Domain ID domain_idd2ch4b3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2ch4w1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.7 — CheW-like
Family Family familyb.40.7.1 — CheW-like
Domain ID domain_idd2ch4y1
Class classb — All beta proteins
Fold Fold foldb.40 — OB-fold
Superfamily Superfamily superfamilyb.40.7 — CheW-like
Family Family familyb.40.7.1 — CheW-like

CATH v4.4 (10 domains)

Domain ID domain_id2ch4A01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology565 — Heat Shock Protein 90
Homologous superfamily homologous superfamily10 — Histidine kinase-like ATPase, C-terminal domain
Domain ID domain_id2ch4A02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id2ch4A03
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily180 — CheA-289, Domain 4
Domain ID domain_id2ch4B01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology565 — Heat Shock Protein 90
Homologous superfamily homologous superfamily10 — Histidine kinase-like ATPase, C-terminal domain
Domain ID domain_id2ch4B02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id2ch4B03
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily180 — CheA-289, Domain 4
Domain ID domain_id2ch4W01
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id2ch4W02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily180 — CheA-289, Domain 4
Domain ID domain_id2ch4Y01
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id2ch4Y02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily180 — CheA-289, Domain 4
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7. Citations (1)