HOMO SAPIENS
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 1 | 与蛋白数一致 |
| UniProt名称 | PK3CG_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 2–960； UniProt 143–1101 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 2chz |
| 沉积日期 deposition_date | 2006-03-16 |
| 结构标题 title | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93 |
| 关键词 keywords | PHOSPHOINOSITIDE, KINASE, LIPID, INHIBITOR, 3-KINASE, SIGNALING, PHENYLTHIAZOLE, QUINAZOLINONE, TRANSFERASE; TRANSFERASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 29.98 Å |
| Rg（电子密度） | 28.94 Å |
| 总 Rg | 29.80 Å |
| 原子数 | 6826 |
| 残基数 | 840 |
| 排除体积 | 122420 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d2chza1 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.15 — beta-Grasp (ubiquitin-like) |
| 超家族 Superfamily superfamily | d.15.1 — Ubiquitin-like |
| 家族 Family family | d.15.1.5 — Ras-binding domain, RBD |
| 结构域编号 domain_id | d2chza2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.7 — C2 domain-like |
| 超家族 Superfamily superfamily | b.7.1 — C2 domain (Calcium/lipid-binding domain, CaLB) |
| 家族 Family family | b.7.1.1 — PLC-like (P variant) |
| 结构域编号 domain_id | d2chza3 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.118 — alpha-alpha superhelix |
| 超家族 Superfamily superfamily | a.118.1 — ARM repeat |
| 家族 Family family | a.118.1.6 — Phoshoinositide 3-kinase (PI3K) helical domain |
| 结构域编号 domain_id | d2chza4 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.4 — Phoshoinositide 3-kinase (PI3K), catalytic domain |
| 结构域编号 domain_id | 2chzA01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 10 — Roll |
| 拓扑 Topology topology | 20 — Ubiquitin-like (UB roll) |
| 同源超家族 H-superfamily homologous superfamily | 90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
| 结构域编号 domain_id | 2chzA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 150 — C2 domain |
| 结构域编号 domain_id | 2chzA03 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 25 — Alpha Horseshoe |
| 拓扑 Topology topology | 40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
| 同源超家族 H-superfamily homologous superfamily | 70 — Phosphatidylinositol 3-kinase, accessory domain (PIK) |
| 结构域编号 domain_id | 2chzA04 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 1010 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
| 结构域编号 domain_id | 2chzA05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1070 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 |
| 同源超家族 H-superfamily homologous superfamily | 11 — Phosphatidylinositol 3-/4-kinase, catalytic domain |