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2cla

CRYSTAL STRUCTURE OF THE ASP-199-ASN MUTANT OF CHLORAMPHENICOL ACETYLTRANSFERASE TO 2.35 ANGSTROMS RESOLUTION. STRUCTURAL CONSEQUENCES OF DISRUPTION OF A BURIED SALT-BRIDGE

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CHLORAMPHENICOL ACETYLTRANSFERASE

Escherichia coli

UniProt P00484

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 COBALT (II) ION × 6 water × 3 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 6 COBALT (II) ION × 12 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1cia 1cia 1cla 1cla 1qca 1qca 2cla 2cla 3cla 3cla 4cla 4cla

13 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CAT3_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–213； UniProt 1–213

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2cla
Deposition date deposition_date1990-04-05
Structure title titleCRYSTAL STRUCTURE OF THE ASP-199-ASN MUTANT OF CHLORAMPHENICOL ACETYLTRANSFERASE TO 2.35 ANGSTROMS RESOLUTION. STRUCTURAL CONSEQUENCES OF DISRUPTION OF A BURIED SALT-BRIDGE
Keywords keywordsTRANSFERASE (ACYLTRANSFERASE); TRANSFERASE (ACYLTRANSFERASE)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2cla__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2cla__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2cla__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.15 Å
Rg (electron density)24.93 Å
Total Rg25.91 Å
Atom count4938
Residues639
Excluded volume88102 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2cla__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2cla__assembly_2__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2claa_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.43 — CoA-dependent acyltransferases
Superfamily Superfamily superfamilyc.43.1 — CoA-dependent acyltransferases
Family Family familyc.43.1.1 — CAT-like

CATH v4.4 (1 domains)

Domain ID domain_id2claA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology559 — Chloramphenicol Acetyltransferase
Homologous superfamily homologous superfamily10 — Chloramphenicol acetyltransferase-like domain
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7. Citations (6)