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2cnw

GDPALF4 complex of the SRP GTPases Ffh and FtsY

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

SIGNAL RECOGNITION PARTICLE PROTEIN

THERMUS AQUATICUS

UniProt O07347

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 CELL DIVISION PROTEIN FTSY × 1 （P83749） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 CELL DIVISION PROTEIN FTSY × 1 （P83749） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 CELL DIVISION PROTEIN FTSY × 1 （P83749） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ffh 1jpj 1jpn 1jpn 1ls1 1ng1 1o87 1o87 2c03 2c03 2c04 2c04

22 assemblies; showing the first 12

Homodimer
2ffh 2ffh 2ffh

3 assemblies

Homotetramer

None

Other homooligomers
2ffh 2ffh 2ffh 2ffh

4 assemblies

Heteromeric or nucleic-acid complex
1okk 1rj9 2cnw 2cnw 2cnw 2iy3 2j7p 2j7p 2xkv 3zn8

10 assemblies

View Construct and Data Evidence
UniProt name SRP54_THEAQ
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–294； UniProt 1–293 Author chain B； PDBConstruct 2–294； UniProt 1–293 Author chain C； PDBConstruct 2–294； UniProt 1–293

CELL DIVISION PROTEIN FTSY

THERMUS AQUATICUS

UniProt P83749

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 SIGNAL RECOGNITION PARTICLE PROTEIN × 1 （O07347） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 SIGNAL RECOGNITION PARTICLE PROTEIN × 1 （O07347） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 SIGNAL RECOGNITION PARTICLE PROTEIN × 1 （O07347） GUANOSINE-5'-DIPHOSPHATE × 2 MAGNESIUM ION × 2 TETRAFLUOROALUMINATE ION × 2 GUANOSINE-5'-MONOPHOSPHATE × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2iyl 2q9a 2q9a 2q9b 2q9b 2q9c 2q9c

7 assemblies

Homodimer
2q9a 2q9a 2q9b 2q9b 2q9c 2q9c

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1okk 1rj9 2cnw 2cnw 2cnw 2j7p 2j7p 2xkv

8 assemblies

View Construct and Data Evidence
UniProt name FTSY_THEAQ
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 1–284； UniProt 20–303 Author chain E； PDBConstruct 1–284； UniProt 20–303 Author chain F； PDBConstruct 1–284； UniProt 20–303

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2cnw
Deposition date deposition_date2006-05-24
Structure title titleGDPALF4 complex of the SRP GTPases Ffh and FtsY
Keywords keywords;INNER MEMBRANE, MEMBRANE TARGETING, NUCLEOTIDE-BINDING, GDP- ALUMINUM FLUORIDE, SIGNAL RECOGNITION PARTICLE, RNA-BINDING, GTP-BINDING, CELL DIVISION, SIGNAL SEQUENCE RECOGNITION, SRP, FFH, FTSY, GTPASE, MEMBRANE, CELL CYCLE, CELL DIVISION-COMPLEX, SIGNAL RECOGNITION ;; SIGNAL RECOGNITION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2cnw__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2cnw__assembly_3__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2cnw__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.45 Å
Rg (electron density)24.57 Å
Total Rg25.40 Å
Atom count4287
Residues550
Excluded volume76721 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2cnw__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2cnw__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2cnw__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd2cnwa1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.1 — Domain of the SRP/SRP receptor G-proteins
Domain ID domain_idd2cnwa2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd2cnwb1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.1 — Domain of the SRP/SRP receptor G-proteins
Domain ID domain_idd2cnwb2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd2cnwc1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.1 — Domain of the SRP/SRP receptor G-proteins
Domain ID domain_idd2cnwc2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd2cnwd1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.0 — automated matches
Domain ID domain_idd2cnwd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd2cnwe1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.1 — Domain of the SRP/SRP receptor G-proteins
Domain ID domain_idd2cnwe2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd2cnwf1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.0 — automated matches
Domain ID domain_idd2cnwf2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like

CATH v4.4 (12 domains)

Domain ID domain_id2cnwA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id2cnwB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id2cnwC01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwC02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id2cnwD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwD02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id2cnwE01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwE02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id2cnwF01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id2cnwF02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)