2gjx

Crystallographic structure of human beta-Hexosaminidase A

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Beta-hexosaminidase alpha chain

物种未注明

UniProt P06865

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase beta chain × 1 (P07686) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 1 water × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase beta chain × 1 (P07686) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 1 water × 2 与蛋白数一致
3 其他组合 异源复合物 蛋白 2 其他聚合物 2 Beta-hexosaminidase beta chain × 1 (P07686) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 2 与蛋白数一致
4 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase beta chain × 1 (P07686) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 2 water × 2 与蛋白数一致
5 其他组合 异源复合物 蛋白 4 其他聚合物 6 Beta-hexosaminidase beta chain × 2 (P07686) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 2 water × 4 与蛋白数一致
6 其他组合 异源复合物 蛋白 4 其他聚合物 5 Beta-hexosaminidase beta chain × 2 (P07686) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 2 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 HEXA_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–507; UniProt 23–529 作者链 D; PDB构建体 1–507; UniProt 23–529 作者链 E; PDB构建体 1–507; UniProt 23–529 作者链 H; PDB构建体 1–507; UniProt 23–529

Beta-hexosaminidase beta chain

物种未注明

UniProt P07686

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase alpha chain × 1 (P06865) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 1 water × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase alpha chain × 1 (P06865) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 1 water × 2 与蛋白数一致
3 其他组合 异源复合物 蛋白 2 其他聚合物 2 Beta-hexosaminidase alpha chain × 1 (P06865) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 2 与蛋白数一致
4 其他组合 异源复合物 蛋白 2 其他聚合物 3 Beta-hexosaminidase alpha chain × 1 (P06865) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SULFATE ION × 2 water × 2 与蛋白数一致
5 其他组合 异源复合物 蛋白 4 其他聚合物 6 Beta-hexosaminidase alpha chain × 2 (P06865) beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 2 water × 4 与蛋白数一致
6 其他组合 异源复合物 蛋白 4 其他聚合物 5 Beta-hexosaminidase alpha chain × 2 (P06865) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SULFATE ION × 2 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 HEXB_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–507; UniProt 50–556 作者链 C; PDB构建体 1–507; UniProt 50–556 作者链 F; PDB构建体 1–507; UniProt 50–556 作者链 G; PDB构建体 1–507; UniProt 50–556

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2gjx
沉积日期 deposition_date2006-03-31
结构标题 titleCrystallographic structure of human beta-Hexosaminidase A
关键词 keywordsbeta-hexosaminidase A, glycosidase, Tay-Sachs disease, GM2 ganglisode, Tim barrel, HYDROLASE; HYDROLASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2gjx__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2gjx__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2gjx__assembly_2__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)32.85 Å
Rg(电子密度)32.10 Å
总 Rg32.85 Å
原子数8009
残基数973
排除体积142710 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2gjx__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2gjx__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2gjx__assembly_3__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 2gjx__assembly_4__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 2gjx__assembly_5__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 2gjx__assembly_6__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (7)

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6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd2gjxa1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxa2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxb1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxb2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxc1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxc2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxd1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxd2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxe1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxe2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxf1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxf2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxg1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxg2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain
结构域编号 domain_idd2gjxh1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamilyc.1.8 — (Trans)glycosidases
家族 Family familyc.1.8.6 — beta-N-acetylhexosaminidase catalytic domain
结构域编号 domain_idd2gjxh2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.92 — Zincin-like
超家族 Superfamily superfamilyd.92.2 — beta-N-acetylhexosaminidase-like domain
家族 Family familyd.92.2.1 — beta-N-acetylhexosaminidase domain

CATH v4.4 (16 domains)

结构域编号 domain_id2gjxA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxA02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxB02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxC01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxC02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxD01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxD02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxE01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxE02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxF01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxF02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxG01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxG02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
结构域编号 domain_id2gjxH01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology379 — Chitobiase; domain 2
同源超家族 H-superfamily homologous superfamily10 — Chitobiase/beta-hexosaminidase domain 2-like
结构域编号 domain_id2gjxH02
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily80 — Glycosidases
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7. 引用文献 (1)