2j0m

Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase.

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

FOCAL ADHESION KINASE 1

GALLUS GALLUS

UniProt Q00944

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 2 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE × 1 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FAK1_CHICK
Isoform —
PDB实体 1, 2
链与序列区间 作者链 A; PDB构建体 3–371; UniProt 31–399 作者链 B; PDB构建体 1–276; UniProt 411–686

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2j0m
沉积日期 deposition_date2006-08-03
结构标题 titleCrystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase.
关键词 keywords;FOCAL ADHESION, CELL MIGRATION, PHOSPHORYLATION, FERM, KINASE, TRANSFERASE, ATP-BINDING, INTEGRIN SIGNALING, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE ;; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2j0m__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2j0m__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2j0m__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)30.66 Å
Rg(电子密度)30.15 Å
总 Rg30.83 Å
原子数4755
残基数586
排除体积85117 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2j0m__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (4)

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6. 折叠分类 (SCOP + CATH) 9 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd2j0ma1
类 Class classa — All alpha proteins
折叠类型 Fold folda.11 — Acyl-CoA binding protein-like
超家族 Superfamily superfamilya.11.2 — Second domain of FERM
家族 Family familya.11.2.0 — automated matches
结构域编号 domain_idd2j0ma2
类 Class classb — All beta proteins
折叠类型 Fold foldb.55 — PH domain-like barrel
超家族 Superfamily superfamilyb.55.1 — PH domain-like
家族 Family familyb.55.1.0 — automated matches
结构域编号 domain_idd2j0ma3
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.1 — Ubiquitin-like
家族 Family familyd.15.1.0 — automated matches
结构域编号 domain_idd2j0mb_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.144 — Protein kinase-like (PK-like)
超家族 Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
家族 Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (5 domains)

结构域编号 domain_id2j0mA01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
结构域编号 domain_id2j0mA02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology80 — Acyl-CoA Binding Protein
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id2j0mA03
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology29 — PH-domain like
同源超家族 H-superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
结构域编号 domain_id2j0mB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology200 — Phosphorylase Kinase; domain 1
同源超家族 H-superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
结构域编号 domain_id2j0mB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology510 — Transferase(Phosphotransferase); domain 1
同源超家族 H-superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
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7. 引用文献 (1)