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2jkk

Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

FOCAL ADHESION KINASE 1

GALLUS GALLUS

UniProt Q00944

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 SULFATE ION × 1 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ktm 1pv3 1qvx 2aeh 2aeh 2al6 2al6 2j0j 2j0k 2j0k 2j0l 2jkk

38 assemblies; showing the first 12

Homodimer
2j0m 4d5k 6gcw 6ty3 6ty4

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2l6f 2l6g 2l6h

3 assemblies

View Construct and Data Evidence
UniProt name FAK1_CHICK
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–276； UniProt 411–686

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2jkk
Deposition date deposition_date2008-08-28
Structure title titleFocal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Keywords keywords;TYROSINE-PROTEIN KINASE, TYROSINE- PROTEIN KINASE, KINASE, MEMBRANE, TRANSFERASE, ATP-BINDING, INTEGRIN SIGNALING, NUCLEOTIDE-BINDING, FOCAL ADHESION, CELL MIGRATION, KINASE INHIBITOR, CELL JUNCTION, CELL MEMBRANE, PHOSPHOPROTEIN ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2jkk__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2jkk__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2jkk__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.50 Å
Rg (electron density)19.33 Å
Total Rg20.25 Å
Atom count2113
Residues258
Excluded volume37863 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2jkk__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2jkka_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (2 domains)

Domain ID domain_id2jkkA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id2jkkA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
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7. Citations (1)