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2kfx

Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Troponin C, slow skeletal and cardiac muscles

Homo sapiens

UniProt P63316

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 CALCIUM ION × 1 N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ap4 1ih0 1spy 2jt0 2jt3 2jt8 2jtz 2jxl 2kdh 2kfx 2l98 2mle

23 assemblies; showing the first 12

Homodimer
1wrk 1wrl 1wrl 1wrl 4gje 4gjf 4gjg

7 assemblies

Homotetramer

None

Other homooligomers
3rv5

1 assemblies

Heteromeric or nucleic-acid complex
1j1d 1j1d 1j1e 1j1e 1lxf 1mxl 1ozs 2kgb 2krd 2l1r 2mkp 2mzp

49 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNNC1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain T； PDBConstruct 1–89； UniProt 1–89

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2kfx
Deposition date deposition_date2009-02-28
Structure title titleStructure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7
Keywords keywords;calcium regulation, striated muscle, cardiac, troponin, W7, cardiotonic drugs, Acetylation, Calcium, Cardiomyopathy, Disease mutation, Muscle protein, Polymorphism, METAL BINDING PROTEIN ;; METAL BINDING PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2kfx__assembly_1__model_2

Assembly 1 · Model 2 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2kfx__assembly_1__model_2 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2kfx__assembly_1__model_2 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.11 Å
Rg (electron density)13.63 Å
Total Rg14.84 Å
Atom count1409
Residues89
Excluded volume12822 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2kfx__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2kfx__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2kfx__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2kfx__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2kfx__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2kfx__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2kfx__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2kfx__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2kfx__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2kfx__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2kfxt_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
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7. Citations (3)