← Back to search
2laz

Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide

Method: SOLUTION NMR
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 ubiquitin-protein ligase SMURF1

Homo sapiens

UniProt Q9HCE7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mothers against decapentaplegic homolog 1 × 1 （Q15797） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3pyc 9fsj 9fsk 9fsk 9fsk 9fsk

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2laz 2lb0 2lb1 2ltx

4 assemblies

View Construct and Data Evidence
UniProt name SMUF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–33； UniProt 235–267

Mothers against decapentaplegic homolog 1

OrganismNot specified

UniProt Q15797

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 E3 ubiquitin-protein ligase SMURF1 × 1 （Q9HCE7） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1khu 1khu

2 assemblies

Heteromeric or nucleic-acid complex
2law 2lax 2lay 2laz 2lb0 2lb1 5zok 5zok

8 assemblies

View Construct and Data Evidence
UniProt name SMAD1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–8； UniProt 210–217

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id2laz
Deposition date deposition_date2011-03-22
Structure title titleStructure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide
Keywords keywordsSMURF, SMAD, CDK, signal transduction, SIGNALING PROTEIN-TRANSCRIPTION complex; SIGNALING PROTEIN/TRANSCRIPTION
Experimental Method methodSOLUTION NMR
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2laz__assembly_1__model_22

Assembly 1 · Model 22 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2laz__assembly_1__model_22 | I(q)

10-2 10-1 104 105 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2laz__assembly_1__model_22 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）11.69 Å
Rg (electron density)10.16 Å
Total Rg11.73 Å
Atom count645
Residues40
Excluded volume5822 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2laz__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2laz__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2laz__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2laz__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2laz__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2laz__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2laz__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2laz__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2laz__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2laz__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2laz__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2laz__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2laz__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2laz__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2laz__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2laz__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2laz__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2laz__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2laz__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2laz__assembly_1__model_20 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 2laz__assembly_1__model_21 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 2laz__assembly_1__model_22 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 2laz__assembly_1__model_23 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 2laz__assembly_1__model_24 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (2)

▶

7. Citations (1)