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2le8

The protein complex for DNA replication

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM6

Homo sapiens

UniProt Q14566

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 DNA replication factor Cdt1 × 1 （Q9H211） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2klq

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
22vt 2le8 6xtx 6xty 7pfo 7plo 7w1y 7w68 8b9d 8rwv 8s09 8s0a

29 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MCM6_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–114； UniProt 708–821

DNA replication factor Cdt1

Homo sapiens

UniProt Q9H211

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 DNA replication licensing factor MCM6 × 1 （Q14566） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2le8 2wvr 6qcg 6qcg 8rwv 8s0e 8s0f

7 assemblies

View Construct and Data Evidence
UniProt name CDT1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–28； UniProt 413–440

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2le8
Deposition date deposition_date2011-06-14
Structure title titleThe protein complex for DNA replication
Keywords keywordsDNA replication, REPLICATION; REPLICATION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2le8__assembly_1__model_2

Assembly 1 · Model 2 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2le8__assembly_1__model_2 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2le8__assembly_1__model_2 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.77 Å
Rg (electron density)17.48 Å
Total Rg18.36 Å
Atom count2358
Residues143
Excluded volume20866 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2le8__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2le8__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2le8__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2le8__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2le8__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2le8__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2le8__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2le8__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2le8__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2le8__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2le8__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2le8__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2le8__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2le8__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2le8__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2le8__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2le8__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2le8__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2le8__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id2le8A00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily870 —
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7. Citations (1)