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2lh8

Syrian hamster prion protein with thiamine

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Major prion protein

Mesocricetus auratus

UniProt P04273

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1b10 2kkg 2lh8 4yxl

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
3nve 7lna 7yat 8wzx

4 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name PRIO_MESAU
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–104； UniProt 125–228

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2lh8
Deposition date deposition_date2011-08-05
Structure title titleSyrian hamster prion protein with thiamine
Keywords keywordsprion, thiamine, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2lh8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2lh8__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2lh8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.73 Å
Rg (electron density)14.56 Å
Total Rg15.59 Å
Atom count1715
Residues104
Excluded volume15472 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2lh8__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2lh8a_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.6 — Prion-like
Superfamily Superfamily superfamilyd.6.1 — Prion-like
Family Family familyd.6.1.1 — Prion-like

CATH v4.4 (1 domains)

Domain ID domain_id2lh8A00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology790 — Major Prion Protein
Homologous superfamily homologous superfamily10 — Prion/Doppel protein, beta-ribbon domain
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7. Citations (1)