SAXSdb — 2lxg

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mu-conotoxin KIIIA

OrganismNot specified

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count	Chain A； UniProt 1–16	Fragment：UNP RESIDUES 1-16 Non-standard monomer：Yes (specific site not provided by mmCIF)	No other associated polymer	SOLUTION NMR NMR measurement conditions：pH 2.9；278 K；Pressure ambient NMR measurement conditions：pH 2.9；283 K NMR measurement conditions：pH 4.8；278 K NMR measurement conditions：pH 4.8；293 K NMR measurement conditions：pH 5.3；278 K NMR sample composition：2.6 mM entity-1, 94% H2O/6% D2O \| 94% H2O/6% D2O NMR sample composition：2.3 mM entity-2, 100% D2O \| 100% D2O	Resolution not provided

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 2LXG	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
6J8E Human Nav1.2-beta2-KIIIA ternary complex Deposited 2019-01-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric	Chain D 5–20（16 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 NA SODIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 5.9 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
7SAV Native mu-conotoxin KIIIA isomer Deposited 2021-09-23	Different construct Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 5–20（16 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 3；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient NMR measurement conditions pH 3；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient NMR sample composition 2.0 mg/mL KIIIA, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition 2.0 mg/mL KIIIA, 100% D2O \| 100% D2O	Resolution not provided
7SAW Mu-conotoxin KIIIA isomer 2 Deposited 2021-09-23	Different construct Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 5–20（16 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 3；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient NMR sample composition 2 mg/mL KIIIA, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition 2 mg/mL KIIIA, 100% D2O \| 100% D2O	Resolution not provided

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CM3A_CONKI
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–16； UniProt 1–16

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2lxg
Deposition date deposition_date	2012-08-21
Structure title title	NMR solution structure of Mu-conotoxin KIIIA
Keywords keywords	conotoxin, disulfide isomer, toxin, Voltage gated sodium channels, helical; TOXIN
Experimental Method method	SOLUTION NMR

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	6.20 Å
Radius of gyration Rg (electron density) rg_electron	6.44 Å
Forward intensity I(0) i0	35812300.00
Molecular weight molecular_weight	37844.0 kDa
Excluded volume excluded_volume	42517 Å³
Envelope volume envelope_volume	3800 Å³
Hydration-shell volume shell_volume	4563 Å³
Envelope diameter envelope_diameter	25.8 Å
Shell Rg shell_rg	12.42 Å
Envelope Rg envelope_rg	8.23 Å
Shape Rg shape_rg	6.44 Å
Total Rg total_rg	6.67 Å
Total atoms total_atoms	4660
Residues n_residues	320
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	22.7 Å
Rg (real space) rg_real	6.19 Å
Rg uncertainty (real space) rg_real_error	0.39 Å
I(0) (real space) i0_real	3.5810e+07
I(0) uncertainty (real space) i0_real_error	3.5970e+05
Rg (reciprocal space) rg_reciprocal	6.19 Å
I(0) (reciprocal space) i0_reciprocal	35810000.0000
Solution quality estimate total_estimate	0.7517
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	3
Primary peak position r_peak_primary	8.0 Å
Skewness Skewness skewness	0.326
Kurtosis Kurtosis kurtosis	0.165
Angular range angular_range	— – 0.5000 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	1952.0000
Real-space data points n_real_points	80
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.622; Stabil: 0.993; Sysdev: 1.000; Positv: 1.000; Valcen: 0.923; Smooth: 0.000

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (1)

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8. Citations (1)

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Description description	Mu-conotoxin KIIIA
Molecular weight formula_weight	1893.2 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	4660

fit	/app/data/saxs_computation/lx/2lxg/2lxg.fit
pddf	/app/data/pr_computation/lx/2lxg/2lxg.pr.out
profile	/app/data/saxs_computation/lx/2lxg/2lxg.dat

NMR solution structure of Mu-conotoxin KIIIA

1. Protein Identity and Related Structures Protein Identity & Related Structures

Mu-conotoxin KIIIA

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

6. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)