2ms7

High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD

Method: SOLID-STATE NMR

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mitochondrial antiviral-signaling protein

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 21	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MAVS_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 3–102； UniProt 1–100 Author chain B； PDBConstruct 3–102； UniProt 1–100 Author chain C； PDBConstruct 3–102； UniProt 1–100 Author chain D； PDBConstruct 3–102； UniProt 1–100 Author chain E； PDBConstruct 3–102； UniProt 1–100 Author chain F； PDBConstruct 3–102； UniProt 1–100 Author chain G； PDBConstruct 3–102； UniProt 1–100 Author chain H； PDBConstruct 3–102； UniProt 1–100 Author chain I； PDBConstruct 3–102； UniProt 1–100 Author chain J； PDBConstruct 3–102； UniProt 1–100 Author chain K； PDBConstruct 3–102； UniProt 1–100 Author chain L； PDBConstruct 3–102； UniProt 1–100 Author chain M； PDBConstruct 3–102； UniProt 1–100 Author chain N； PDBConstruct 3–102； UniProt 1–100 Author chain O； PDBConstruct 3–102； UniProt 1–100 Author chain P； PDBConstruct 3–102； UniProt 1–100 Author chain Q； PDBConstruct 3–102； UniProt 1–100 Author chain R； PDBConstruct 3–102； UniProt 1–100 Author chain S； PDBConstruct 3–102； UniProt 1–100 Author chain T； PDBConstruct 3–102； UniProt 1–100 Author chain U； PDBConstruct 3–102； UniProt 1–100

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2ms7
Deposition date deposition_date	2014-07-25
Structure title title	High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD
Keywords keywords	MAVS CARD filament, PROTEIN BINDING; PROTEIN BINDING
Experimental Method method	SOLID-STATE NMR

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2ms7__assembly_1__model_3

Assembly 1 · Model 3 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2ms7__assembly_1__model_3 | I(q)

100 plotted points; both axes use logarithmic scales.

2ms7__assembly_1__model_3 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	41.03 Å
Rg (electron density)	40.56 Å
Total Rg	40.95 Å
Atom count	34314
Residues	2142
Excluded volume	308120 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`2ms7__assembly_1__model_1`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	2	`2ms7__assembly_1__model_2`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	3	`2ms7__assembly_1__model_3`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	4	`2ms7__assembly_1__model_4`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	5	`2ms7__assembly_1__model_5`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	6	`2ms7__assembly_1__model_6`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	7	`2ms7__assembly_1__model_7`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	8	`2ms7__assembly_1__model_8`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	9	`2ms7__assembly_1__model_9`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	10	`2ms7__assembly_1__model_10`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	11	`2ms7__assembly_1__model_11`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	12	`2ms7__assembly_1__model_12`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	13	`2ms7__assembly_1__model_13`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	14	`2ms7__assembly_1__model_14`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	15	`2ms7__assembly_1__model_15`	21-meric （21）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 21 domains

CATH v4.4 (21 domains)

Domain ID domain_id	2ms7A00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7B00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7C00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7D00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7E00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7F00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7G00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7H00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7I00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7J00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7K00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7L00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7M00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7N00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7O00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7P00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7Q00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7R00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7S00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7T00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

Domain ID domain_id	2ms7U00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	533 — Death Domain, Fas
Homologous superfamily homologous superfamily	10 — Death Domain, Fas

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Description description	Mitochondrial antiviral-signaling protein
Molecular weight formula_weight	11817.4 kDa
Source method src_method	man
Copy count entity_count	21

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U
Atom count atom_count	514710

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD

1. Protein Identity and Related Structures Protein Identity & Related Structures

Mitochondrial antiviral-signaling protein

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2ms7__assembly_1__model_3

2ms7__assembly_1__model_3 | I(q)

2ms7__assembly_1__model_3 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 21 domains

CATH v4.4 (21 domains)

7. Citations (1)

High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD

1. Protein Identity and Related Structures Protein Identity & Related Structures

Mitochondrial antiviral-signaling protein

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2ms7__assembly_1__model_3

2ms7__assembly_1__model_3 | I(q)

2ms7__assembly_1__model_3 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 21 domains

CATH v4.4 (21 domains)

7. Citations (1)