← Back to search
4p4h

Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Probable ATP-dependent RNA helicase DDX58

Homo sapiens

UniProt O95786

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 21 Mitochondrial antiviral-signaling protein × 8 （Q7Z434） Ubiquitin-60S ribosomal protein L40 × 5 （P62987） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2lwd 2lwe 2qfb 2qfb 2qfb 2qfb 2qfb 2qfb 2qfb 2qfb 2qfb 2qfb

25 assemblies; showing the first 12

Homodimer
4on9

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ykg 3lrn 3lrr 3ncu 3og8 3zd6 3zd7 4ay2 4bpb 4nqk 4p4h 5e3h

45 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DDX58_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–205； UniProt 1–201 Author chain B； PDBConstruct 5–205； UniProt 1–201 Author chain C； PDBConstruct 5–205； UniProt 1–201 Author chain D； PDBConstruct 5–205； UniProt 1–201 Author chain E； PDBConstruct 5–205； UniProt 1–201 Author chain F； PDBConstruct 5–205； UniProt 1–201 Author chain G； PDBConstruct 5–205； UniProt 1–201 Author chain H； PDBConstruct 5–205； UniProt 1–201

Mitochondrial antiviral-signaling protein

Homo sapiens

UniProt Q7Z434

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 21 Probable ATP-dependent RNA helicase DDX58 × 8 （O95786） Ubiquitin-60S ribosomal protein L40 × 5 （P62987） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2ms8 3j6c 3j6c

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
2ms7 3j6c 3j6j 8wkw

4 assemblies

Heteromeric or nucleic-acid complex
2vgq 4p4h 4z8m 4z8m 7dni

5 assemblies

View Construct and Data Evidence
UniProt name MAVS_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain I； PDBConstruct 10–108； UniProt 1–99 Author chain J； PDBConstruct 10–108； UniProt 1–99 Author chain K； PDBConstruct 10–108； UniProt 1–99 Author chain L； PDBConstruct 10–108； UniProt 1–99 Author chain M； PDBConstruct 10–108； UniProt 1–99 Author chain N； PDBConstruct 10–108； UniProt 1–99 Author chain O； PDBConstruct 10–108； UniProt 1–99 Author chain P； PDBConstruct 10–108； UniProt 1–99

Ubiquitin-60S ribosomal protein L40

Homo sapiens

UniProt P62987

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 21 Probable ATP-dependent RNA helicase DDX58 × 8 （O95786） Mitochondrial antiviral-signaling protein × 8 （Q7Z434） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2lj5 2mjb 4jio 4pig 4pig 4pig 4pig 4pih 4pih 4pij 4pij 9pl1

12 assemblies

Homodimer
4pih 4pih 4pij 4pij 4pij

5 assemblies

Homotetramer
4pig

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
11ta 22tu 28ln 2mur 2n3u 2n3v 2n3w 4p4h 4rf0 4rf1 4s1z 4s1z

157 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RL40_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain S； PDBConstruct 4–79； UniProt 1–76 Author chain T； PDBConstruct 4–79； UniProt 1–76 Author chain U； PDBConstruct 4–79； UniProt 1–76 Author chain W； PDBConstruct 4–79； UniProt 1–76 Author chain X； PDBConstruct 4–79； UniProt 1–76

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id4p4h
Deposition date deposition_date2014-03-12
Structure title titleCaught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain
Keywords keywordssignaling protein, signaling complex; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4p4h__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4p4h__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4p4h__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）44.31 Å
Rg (electron density)43.88 Å
Total Rg44.28 Å
Atom count43332
Residues2644
Excluded volume390120 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4p4h__assembly_1__model_1 21-meric （21） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (3)

▼

6. Fold Classification (SCOP + CATH) 24 domains

CATH v4.4 (24 domains)

Domain ID domain_id4p4hA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hC02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hE01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hE02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hF02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hG01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hG02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hH01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hH02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hI00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hJ00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hK00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hL00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hM00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hN00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hO00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4p4hP00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
▶

7. Citations (1)