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2n8r

Productive complex between MMP-12 and synthetic triple-helical collagen, revealed through paramagnetic NMR

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Macrophage metalloelastase

Homo sapiens

UniProt P39900

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Collagen triple helix repeat family protein × 3 ZINC ION × 2 CALCIUM ION × 3 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jiz 1jiz 1jk3 1os2 1os2 1os2 1os2 1os2 1os2 1os9 1os9 1os9

122 assemblies; showing the first 12

Homodimer
1jk3 1jk3 1os2 1os9 1os9 4h30 4h49 4h49

8 assemblies

Homotetramer

None

Other homooligomers
1os2 1os2 1os9 1os9 1utt 1utz

6 assemblies

Heteromeric or nucleic-acid complex
2n8r 2oxw 2oxz 8b2n 8b2n

5 assemblies

View Construct and Data Evidence
UniProt name MMP12_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–164； UniProt 100–263

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2n8r
Deposition date deposition_date2015-10-24
Structure title titleProductive complex between MMP-12 and synthetic triple-helical collagen, revealed through paramagnetic NMR
Keywords keywordsCollagenolysis, matrix petalloproteinase, HYDROLASE-STRUCTURAL PROTEIN complex; HYDROLASE/STRUCTURAL PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2n8r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2n8r__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2n8r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.38 Å
Rg (electron density)22.56 Å
Total Rg22.97 Å
Atom count3847
Residues248
Excluded volume35044 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2n8r__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2n8ra_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.92 — Zincin-like
Superfamily Superfamily superfamilyd.92.1 — Metalloproteases ('zincins'), catalytic domain
Family Family familyd.92.1.11 — Matrix metalloproteases, catalytic domain

CATH v4.4 (1 domains)

Domain ID domain_id2n8rA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology390 — Collagenase (Catalytic Domain)
Homologous superfamily homologous superfamily10 — Collagenase (Catalytic Domain)
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7. Citations (2)