Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | ZINC ION × 1 YTTERBIUM (III) ION × 1 N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine × 1 ACETIC ACID × 1 water × 1 | 与蛋白数一致 |
| UniProt名称 | LKHA4_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 7–616； UniProt 2–611 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 2r59 |
| 沉积日期 deposition_date | 2007-09-03 |
| 结构标题 title | Leukotriene A4 hydrolase complexed with inhibitor RB3041 |
| 关键词 keywords | ;transition state, analogue peptide, hydrolysis, Alternative splicing, Cytoplasm, Hydrolase, Leukotriene biosynthesis, Metal-binding, Metalloprotease, Multifunctional enzyme, Protease, Zinc ;; HYDROLASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 25.99 Å |
| Rg（电子密度） | 24.87 Å |
| 总 Rg | 25.90 Å |
| 原子数 | 4918 |
| 残基数 | 610 |
| 排除体积 | 88037 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d2r59a1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.118 — alpha-alpha superhelix |
| 超家族 Superfamily superfamily | a.118.1 — ARM repeat |
| 家族 Family family | a.118.1.7 — Leukotriene A4 hydrolase C-terminal domain |
| 结构域编号 domain_id | d2r59a2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.98 — Zn aminopeptidase N-terminal domain |
| 超家族 Superfamily superfamily | b.98.1 — Zn aminopeptidase N-terminal domain |
| 家族 Family family | b.98.1.1 — Zn aminopeptidase N-terminal domain |
| 结构域编号 domain_id | d2r59a3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.92 — Zincin-like |
| 超家族 Superfamily superfamily | d.92.1 — Metalloproteases ('zincins'), catalytic domain |
| 家族 Family family | d.92.1.13 — Zn aminopeptidase catalytic domain |
| 结构域编号 domain_id | 2r59A01 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 1730 — tricorn interacting facor f3 domain |
| 结构域编号 domain_id | 2r59A02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 2010 — Zincin-like |
| 同源超家族 H-superfamily homologous superfamily | 30 — |
| 结构域编号 domain_id | 2r59A03 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 390 — Neutral Protease; domain 2 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Neutral Protease Domain 2 |
| 结构域编号 domain_id | 2r59A04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 25 — Alpha Horseshoe |
| 拓扑 Topology topology | 40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
| 同源超家族 H-superfamily homologous superfamily | 320 — Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain |