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5ni4

Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form II)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Leukotriene A-4 hydrolase

Homo sapiens

UniProt P09960

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 ZINC ION × 3 IMIDAZOLE × 7 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid × 3 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1gw6 1h19 1hs6 1sqm 2r59 3b7r 3b7u 3cho 3chp 3chq 3chr 3chs

82 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
5ni4

1 assemblies

Heteromeric or nucleic-acid complex
3b7s 3b7t 6enb

3 assemblies

View Construct and Data Evidence
UniProt name LKHA4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 8–617； UniProt 2–611 Author chain B； PDBConstruct 8–617； UniProt 2–611 Author chain C； PDBConstruct 8–617； UniProt 2–611

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5ni4
Deposition date deposition_date2017-03-23
Structure title titleCrystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form II)
Keywords keywordsMetallopeptidase, epoxide hydrolase, leukotriene A4, hydrolase; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5ni4__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5ni4__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5ni4__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.24 Å
Rg (electron density)41.82 Å
Total Rg42.06 Å
Atom count29251
Residues1823
Excluded volume262770 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5ni4__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 21 domains

SCOP 2.08 (9 domains)

Domain ID domain_idd5ni4a1
Class classb — All beta proteins
Fold Fold foldb.98 — Zn aminopeptidase N-terminal domain
Superfamily Superfamily superfamilyb.98.1 — Zn aminopeptidase N-terminal domain
Family Family familyb.98.1.1 — Zn aminopeptidase N-terminal domain
Domain ID domain_idd5ni4a2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.92 — Zincin-like
Superfamily Superfamily superfamilyd.92.1 — Metalloproteases ('zincins'), catalytic domain
Family Family familyd.92.1.13 — Zn aminopeptidase catalytic domain
Domain ID domain_idd5ni4a3
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.7 — Leukotriene A4 hydrolase C-terminal domain
Domain ID domain_idd5ni4b1
Class classb — All beta proteins
Fold Fold foldb.98 — Zn aminopeptidase N-terminal domain
Superfamily Superfamily superfamilyb.98.1 — Zn aminopeptidase N-terminal domain
Family Family familyb.98.1.1 — Zn aminopeptidase N-terminal domain
Domain ID domain_idd5ni4b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.92 — Zincin-like
Superfamily Superfamily superfamilyd.92.1 — Metalloproteases ('zincins'), catalytic domain
Family Family familyd.92.1.13 — Zn aminopeptidase catalytic domain
Domain ID domain_idd5ni4b3
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.7 — Leukotriene A4 hydrolase C-terminal domain
Domain ID domain_idd5ni4c1
Class classb — All beta proteins
Fold Fold foldb.98 — Zn aminopeptidase N-terminal domain
Superfamily Superfamily superfamilyb.98.1 — Zn aminopeptidase N-terminal domain
Family Family familyb.98.1.1 — Zn aminopeptidase N-terminal domain
Domain ID domain_idd5ni4c2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.92 — Zincin-like
Superfamily Superfamily superfamilyd.92.1 — Metalloproteases ('zincins'), catalytic domain
Family Family familyd.92.1.13 — Zn aminopeptidase catalytic domain
Domain ID domain_idd5ni4c3
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.7 — Leukotriene A4 hydrolase C-terminal domain

CATH v4.4 (12 domains)

Domain ID domain_id5ni4A01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily1730 — tricorn interacting facor f3 domain
Domain ID domain_id5ni4A02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology2010 — Zincin-like
Homologous superfamily homologous superfamily30 —
Domain ID domain_id5ni4A03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology390 — Neutral Protease; domain 2
Homologous superfamily homologous superfamily10 — Neutral Protease Domain 2
Domain ID domain_id5ni4A04
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily320 — Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain
Domain ID domain_id5ni4B01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily1730 — tricorn interacting facor f3 domain
Domain ID domain_id5ni4B02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology2010 — Zincin-like
Homologous superfamily homologous superfamily30 —
Domain ID domain_id5ni4B03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology390 — Neutral Protease; domain 2
Homologous superfamily homologous superfamily10 — Neutral Protease Domain 2
Domain ID domain_id5ni4B04
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily320 — Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain
Domain ID domain_id5ni4C01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily1730 — tricorn interacting facor f3 domain
Domain ID domain_id5ni4C02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology2010 — Zincin-like
Homologous superfamily homologous superfamily30 —
Domain ID domain_id5ni4C03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology390 — Neutral Protease; domain 2
Homologous superfamily homologous superfamily10 — Neutral Protease Domain 2
Domain ID domain_id5ni4C04
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily320 — Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain
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7. Citations (1)