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2uvm

Structure of PKBalpha PH domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4-tetrakisphosphate

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE

HOMO SAPIENS

UniProt P31749

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)] × 1 SODIUM ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1h10 1unp 1unq 1unr 2uvm 2uzr 2uzs 3o96 3qkm 4ejn 4ekl 4gv1

23 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3cqu 3cqw 3ow4 3ow4 3qkk 3qkl 4ekk 4ekk 6buu 6buu 6ccy 6npz

19 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name AKT1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–123； UniProt 1–123

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2uvm
Deposition date deposition_date2007-03-12
Structure title titleStructure of PKBalpha PH domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4-tetrakisphosphate
Keywords keywords;TRANSFERASE, GLYCOGEN BIOSYNTHESIS, TRANSLATION REGULATION, SERINE/THREONINE-PROTEIN KINASE, PHOSPHOINOSITIDE, PROTEIN KINASE B, GLUCOSE METABOLISM, NUCLEAR PROTEIN, CELL SIGNALLING, PHOSPHORYLATION, NUCLEOTIDE-BINDING, GLYCOGEN METABOLISM, KINASE, CANCER, INOSITOL, APOPTOSIS, TRANSPORT, CARBOHYDRATE METABOLISM, PH DOMAIN, ATP-BINDING, SUGAR TRANSPORT ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2uvm__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2uvm__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2uvm__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.34 Å
Rg (electron density)13.99 Å
Total Rg15.23 Å
Atom count956
Residues116
Excluded volume16781 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2uvm__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2uvma_
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.1 — Pleckstrin-homology domain (PH domain)

CATH v4.4 (1 domains)

Domain ID domain_id2uvmA00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
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7. Citations (1)