HOMO SAPIENS
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 其他组合 | 单体 | 蛋白 1 其他聚合物 1 | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose × 1 ACETATE ION × 1 CHLORIDE ION × 2 SULFATE ION × 3 water × 1 | 与蛋白数一致 |
| UniProt名称 | CFAH_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 3–187； UniProt 322–506 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 2uwn |
| 沉积日期 deposition_date | 2007-03-22 |
| 结构标题 title | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. |
| 关键词 keywords | ;ALTERNATIVE SPLICING, SUCROSE OCTASULPHATE, AGE-RELATED MACULAR DEGENERATION, COMPLEMENT ALTERNATE PATHWAY, DISEASE MUTATION, GLYCOSAMINOGLYCAN, GLYCOPROTEIN, INNATE IMMUNITY, IMMUNE RESPONSE, SUSHI, FACTOR H, COMPLEMENT, POLYMORPHISM, IMMUNE SYSTEM ;; IMMUNE SYSTEM |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 27.27 Å |
| Rg（电子密度） | 28.31 Å |
| 总 Rg | 28.29 Å |
| 原子数 | 1555 |
| 残基数 | 187 |
| 排除体积 | 27096 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | 2uwnA01 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 10 — Ribbon |
| 拓扑 Topology topology | 70 — Complement Module; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Complement Module, domain 1 |
| 结构域编号 domain_id | 2uwnA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 10 — Ribbon |
| 拓扑 Topology topology | 70 — Complement Module; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Complement Module, domain 1 |
| 结构域编号 domain_id | 2uwnA03 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 10 — Ribbon |
| 拓扑 Topology topology | 70 — Complement Module; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Complement Module, domain 1 |