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2g7i

Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for Atypical Hemolytic Uremic Syndrome

Method: X-RAY DIFFRACTION Dmax: 76.7 Å Quality: REASONABLE
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Complement factor H

Homo sapiens

UniProt P08603

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain A； UniProt 1107–1231 Fragment：C-terminal Domains 19-20 No other associated polymer X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 8.5；298 K；Before crystallization the protein was concentrated to 10 mg/ml and dialysed into 20 mM Tris, 50 mM NaCl, pH 7.0. The protein was crystallized in sitting drops by mixing 1 ul of protein solution at 10 mg/ml with 1 ul of reservoir solution of 2.2 M (NH4)2SO4, 0.1 M Tris-HCl, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K Resolution 1.75 Å R-free 0.225

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2G7I Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1HAQ FOUR MODELS OF HUMAN FACTOR H DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING Deposited 2001-04-06 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–1231（1213 aa）
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
1HCC THREE-DIMENSIONAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN MODULE IN SOLUTION Deposited 1990-11-28 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 927–985（59 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1HFH SOLUTION STRUCTURE OF A PAIR OF COMPLEMENT MODULES BY NUCLEAR MAGNETIC RESONANCE Deposited 1993-02-23 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 866–985（120 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1HFI SOLUTION STRUCTURE OF A PAIR OF COMPLEMENT MODULES BY NUCLEAR MAGNETIC RESONANCE Deposited 1993-02-23 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 866–927（62 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
2BZM Solution structure of the primary host recognition region of complement factor H Deposited 2005-08-18 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1107–1231（125 aa） Fragment：CCPS 19-20, RESIDUES 1107-1231
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4；310 K；Ionic strength (raw mmCIF value) 200；Pressure 1.0
NMR sample composition 10% WATER/90% D2O
Resolution not provided
2IC4 Solution structure of the His402 allotype of the Factor H SCR6-SCR7-SCR8 fragment Deposited 2006-09-12 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 321–506（186 aa） Fragment：Factor H SCR6-SCR7-SCR8
Not recorded No recorded non-water small molecule SOLUTION SCATTERING
X-ray crystallization conditions pH 7.3；288 K；SOLUTION, pH 7.3, temperature 288K
Resolution not provided
2JGW Structure of CCP module 7 of complement factor H - The AMD at risk varient (402H) Deposited 2007-02-16 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 386–446（61 aa） Fragment：CCP MODULE 7, RESIDUES 386-446
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.2；298 K；Ionic strength (raw mmCIF value) 20；Pressure 1.0
NMR measurement conditions pH 5.2；298 K；Ionic strength (raw mmCIF value) 20；Pressure 1.0
NMR sample composition 10% WATER/90% D2O
Resolution not provided
2JGX Structure of CCP module 7 of complement factor H - The AMD Not at risk varient (402Y) Deposited 2007-02-16 Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 386–446（61 aa） Fragment：CCP MODULE 7, RESIDUES 386-446
Mutation：YES No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.2；298 K；Ionic strength (raw mmCIF value) 20；Pressure 1.0
NMR measurement conditions pH 5.2；298 K；Ionic strength (raw mmCIF value) 20；Pressure 1.0
NMR sample composition 10% WATER/90% D2O
Resolution not provided
2KMS Combined high- and low-resolution techniques reveal compact structure in central portion of factor H despite long inter-modular linkers Deposited 2009-08-04 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 690–804（115 aa） Fragment：Sushi domain, residues 690-804
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.6；298 K；Ionic strength (raw mmCIF value) 20；Pressure ambient
NMR sample composition 20mM potassium phosphate-1, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
2QFG Solution Structure of the N-terminal SCR-1/5 fragment of Complement Factor H. Deposited 2007-06-27 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–322（304 aa） Fragment：SCR domains 1-5 (residues 19-322)
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
2QFH Solution Structure of the C-terminal SCR-16/20 fragment of Complement Factor H. Deposited 2007-06-27 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 928–1231（304 aa） Fragment：SCR domains 16-20 (residues 928-1231)
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
2RLP NMR structure of CCP modules 1-2 of complement factor H Deposited 2007-07-28 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 20–142（123 aa） Fragment：residues in database 20-142
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.2；310 K；Pressure ambient
NMR sample composition 1mM [U-95% 13C; U-95% 15N] FactorH CCP1-2, 10mM potassium phosphate, 12mg/mL Pf1 phage, 50mM L-Arg, 50mM L-Glu, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM FactorH CCP1-2, 10mM potassium phosphate, 50mM L-Arg, 50mM L-Glu, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM FactorH CCP1-2, 10mM potassium phosphate, 50mM L-Arg, 50mM L-Glu, 100% D2O | 100% D2O
Resolution not provided
2RLQ NMR structure of CCP modules 2-3 of complement factor H Deposited 2007-07-29 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 84–206（123 aa） Fragment：residues in database 84-206
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.2；310 K；Pressure ambient
NMR sample composition 2mM [U-95% 13C; U-95% 15N] FactorH CCP2-3, 10mM potassium phosphate, 12mg/mL Pf1 phage, 50mM L-Arg, 50mM L-Glu, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 3mM FactorH CCP2-3, 10mM potassium phosphate, 50mM L-Arg, 50mM L-Glu, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM FactorH CCP2-3, 10mM potassium phosphate, 50mM L-Arg, 50mM L-Glu, 100% D2O | 100% D2O
Resolution not provided
2UWN Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. Deposited 2007-03-22 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric
Chain A 322–506（185 aa） Fragment：DOMAINS 6,7 AND 8, RESIDUES 322-506
Not recorded ACT ACETATE ION × 1 CL CHLORIDE ION × 2 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.5；0.1M SODIUM ACETATE, PH4.5, 20% (W/V) PEG3000
Resolution 2.35 Å R-free 0.246
2V8E Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. Deposited 2007-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric
Chain A 322–506（185 aa） Fragment：DOMAINS 6,7 AND 8, RESIDUES 322-506
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 SO4 SULFATE ION × 3 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.5；0.1M SODIUM ACETATE, PH4.5, 20% (W/V) PEG3000
Resolution 2.50 Å R-free 0.245
2W80 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH9.0
Resolution 2.35 Å R-free 0.263
2W80 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH9.0
Resolution 2.35 Å R-free 0.263
2W80 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH9.0
Resolution 2.35 Å R-free 0.263
2W80 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH9.0
Resolution 2.35 Å R-free 0.263
2W81 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.35 Å R-free 0.283
2W81 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.35 Å R-free 0.283
2W81 Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H Deposited 2009-01-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.35 Å R-free 0.283
2WII Complement C3b in complex with factor H domains 1-4 Deposited 2009-05-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 18–264（247 aa） Fragment：RESIDUES 18-264
Not recorded CA CALCIUM ION × 1 GOL GLYCEROL × 17 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.1；7.0% (W/V) PEG 3,350, 70 MM AMMONIUM ACETATE, PH 7.1
Resolution 2.70 Å R-free 0.252
2WII Complement C3b in complex with factor H domains 1-4 Deposited 2009-05-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 18–264（247 aa） Fragment：RESIDUES 18-264
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.1；7.0% (W/V) PEG 3,350, 70 MM AMMONIUM ACETATE, PH 7.1
Resolution 2.70 Å R-free 0.252
2XQW Structure of Factor H domains 19-20 in complex with complement C3d Deposited 2010-09-07 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1103–1231（129 aa） Fragment：DOMAINS 19-20, RESIDUES 1103-1231
Mutation：YES No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；295 K；12-18% PEG 4000, 0.1 M HEPES, PH 7.5, AT 22 DEGREES C
Resolution 2.31 Å R-free 0.242
2XQW Structure of Factor H domains 19-20 in complex with complement C3d Deposited 2010-09-07 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 1103–1231（129 aa） Fragment：DOMAINS 19-20, RESIDUES 1103-1231
Mutation：YES No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；295 K；12-18% PEG 4000, 0.1 M HEPES, PH 7.5, AT 22 DEGREES C
Resolution 2.31 Å R-free 0.242
3GAU Solution structure of Human Complement Factor H in 50 mM NaCl buffer Deposited 2009-02-18 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–1231（1213 aa）
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
3GAV Solution structure of Human Complement Factor H in 137 mM NaCl buffer Deposited 2009-02-18 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–1231（1213 aa）
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
3GAW Solution structure of Human Complement Factor H in 250 mM NaCl buffer Deposited 2009-02-18 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–1231（1213 aa）
Not recorded No recorded non-water small molecule SOLUTION SCATTERING mmCIF provides none of the parsed conditions Resolution not provided
3KXV Structure of complement Factor H variant Q1139A Deposited 2009-12-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1103–1231（129 aa） Fragment：Sushi domains 19-20
Mutation：Q1139A SO4 SULFATE ION × 24 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；295.15 K；2M ammonium sulphate, 0.1M Bis-Tris buffer, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 295.15K
Resolution 2.00 Å R-free 0.244
3KZJ Structure of complement Factor H variant R1203A Deposited 2009-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 1103–1231（129 aa） Fragment：Sushi domains 19-20
Mutation：R1203A SO4 SULFATE ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；295.15 K；2M Ammonium Sulphate, 0.1M Bis-Tris buffer, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 295.15K
Resolution 1.65 Å R-free 0.222
3R62 Structure of complement regulator Factor H mutant, T1184R. Deposited 2011-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1107–1231（125 aa） Fragment：Complement Factor H modules 19 and 20
Mutation：T1184R GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；290 K；0.1M Tris HCl, pH 8.5 and 12% polyethylene glycol 8000 , VAPOR DIFFUSION, HANGING DROP, temperature 290K
Resolution 1.52 Å R-free 0.208
3R62 Structure of complement regulator Factor H mutant, T1184R. Deposited 2011-03-21 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1107–1231（125 aa） Fragment：Complement Factor H modules 19 and 20
Mutation：T1184R No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；290 K；0.1M Tris HCl, pH 8.5 and 12% polyethylene glycol 8000 , VAPOR DIFFUSION, HANGING DROP, temperature 290K
Resolution 1.52 Å R-free 0.208
3SW0 Structure of the C-terminal region (modules 18-20) of complement regulator Factor H Deposited 2011-07-13 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain X 1046–1231（186 aa） Fragment：unp residues 1046-1231
Not recorded GOL GLYCEROL × 4 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；290 K；0.1M Sodium Acetate trihydrate, pH 4.6, 2% v/v Tacsimate, pH 4.0 (Hampton Research formulation containing: 1.8305 M Malonic acid, 0.25 M Ammonium citrate tribasic, 0.12 M Succinic acid, 0.3 M DL-Malic acid, 0.4 M Sodium acetate trihydrate, 0.5 M Sodium formate, 0.16 M Ammonium tartrate dibasic and pH adjusted using NaOH) and 16% w/v polyethylene glycol 3350 as the precipitant, VAPOR DIFFUSION, HANGING DROP, temperature 290K
Resolution 1.80 Å R-free 0.226
4AYD Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.40 Å R-free 0.231
4AYD Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.40 Å R-free 0.231
4AYD Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.40 Å R-free 0.231
4AYE Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 7 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.80 Å R-free 0.226
4AYE Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 7 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.80 Å R-free 0.226
4AYE Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant Deposited 2012-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；20% PEG 6000, 0.1M BICINE PH 9.0
Resolution 2.80 Å R-free 0.226
4AYI Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 Wild type Deposited 2012-06-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6 20% PEG 4000
Resolution 2.31 Å R-free 0.252
4AYI Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 Wild type Deposited 2012-06-21 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6 20% PEG 4000
Resolution 2.31 Å R-free 0.252
4AYM Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant Deposited 2012-06-21 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6, 20% PEG 4000
Resolution 3.00 Å R-free 0.257
4AYM Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant Deposited 2012-06-21 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6, 20% PEG 4000
Resolution 3.00 Å R-free 0.257
4AYM Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant Deposited 2012-06-21 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6, 20% PEG 4000
Resolution 3.00 Å R-free 0.257
4AYM Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant Deposited 2012-06-21 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain F 321–443（123 aa） Fragment：CCPS 6 AND 7, RESIDUES 321-443
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE PH 6, 20% PEG 4000
Resolution 3.00 Å R-free 0.257
4B2R Solution structure of CCP modules 10-11 of complement factor H Deposited 2012-07-17 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 566–687（122 aa） Fragment：CCPS 10-11, RESIDUES 566-687
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.7；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR measurement conditions pH 6.7；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR measurement conditions pH 6.7；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR measurement conditions pH 6.7；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR sample composition 90% H2O/10% D2O
NMR sample composition 90% H2O/10% D2O 90% H2O/10% D2O
NMR sample composition 90% H2O/10% D2O
Resolution not provided
4B2S Solution structure of CCP modules 11-12 of complement factor H Deposited 2012-07-17 Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 627–747（121 aa） Fragment：CCPS 11-12, RESIDUES 627-747
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.3；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR measurement conditions pH 6.3；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure 1.0
NMR sample composition 90% H2O/10% D2O
Resolution not provided
4J38 Structure of Borrelia burgdorferi Outer surface protein E in complex with Factor H domains 19-20 Deposited 2013-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1103–1231（129 aa） Fragment：FH domains 19-20, UNP residues 1103-1231
Mutation：D1119G, Q1139A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；2M Ammonium sulfate, 0.1M Citric acid, 0.2M Sodium chloride, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.83 Å R-free 0.255
4K12 Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae Deposited 2013-04-04 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 508–567（60 aa） Fragment：sushi domain (UNP residues 508-567)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；20% PEG3500, 0.1 M sodium acetate, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；20% PEG3500, 0.1 M sodium acetate, soaked in 0.5 M sodium iodide, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.08 Å R-free 0.170
4ONT Ternary host recognition complex of complement factor H, C3d, and sialic acid Deposited 2014-01-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1107–1231（125 aa） Fragment：Sushi 19-20 domains (UNP residues 1107-1231)
Not recorded GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；0.1 M Tris-HCl, pH 9.0, 8% w/v PEG8000, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.15 Å R-free 0.223
4ONT Ternary host recognition complex of complement factor H, C3d, and sialic acid Deposited 2014-01-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1107–1231（125 aa） Fragment：Sushi 19-20 domains (UNP residues 1107-1231)
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；0.1 M Tris-HCl, pH 9.0, 8% w/v PEG8000, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.15 Å R-free 0.223
4ONT Ternary host recognition complex of complement factor H, C3d, and sialic acid Deposited 2014-01-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1107–1231（125 aa） Fragment：Sushi 19-20 domains (UNP residues 1107-1231)
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；0.1 M Tris-HCl, pH 9.0, 8% w/v PEG8000, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.15 Å R-free 0.223
4ZH1 Complement factor H in complex with the GM1 glycan Deposited 2015-04-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1107–1231（125 aa） Fragment：residues 1107-1231
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M TRIS-HCL, PH 9.0, 8% W/V PRG 8000
Resolution 2.24 Å R-free 0.228
4ZH1 Complement factor H in complex with the GM1 glycan Deposited 2015-04-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1107–1231（125 aa） Fragment：residues 1107-1231
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M TRIS-HCL, PH 9.0, 8% W/V PRG 8000
Resolution 2.24 Å R-free 0.228
4ZH1 Complement factor H in complex with the GM1 glycan Deposited 2015-04-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1107–1231（125 aa） Fragment：residues 1107-1231
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M TRIS-HCL, PH 9.0, 8% W/V PRG 8000
Resolution 2.24 Å R-free 0.228
5NBQ The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg Deposited 2017-03-02 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1104–1230（127 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 24% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 16% PEG3350, Tris pH 8.5, 0.2 M ammonium acetate
Resolution 3.18 Å R-free 0.261
5NBQ The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg Deposited 2017-03-02 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 1104–1230（127 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 24% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 16% PEG3350, Tris pH 8.5, 0.2 M ammonium acetate
Resolution 3.18 Å R-free 0.261
5NBQ The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg Deposited 2017-03-02 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 1104–1230（127 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 24% PEG3350, 0.1 M HEPES pH 7.5, 0.2 M MgCl2 or 16% PEG3350, Tris pH 8.5, 0.2 M ammonium acetate
Resolution 3.18 Å R-free 0.261
5O32 The structure of complement complex Deposited 2017-05-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: decameric
Chain C 19–264（246 aa） Fragment：UNP residues 19-264,UNP residues 1107-1230,UNP residues 19-264,UNP residues 1107-1230
Chain C 1107–1230（124 aa） Fragment：UNP residues 19-264,UNP residues 1107-1230,UNP residues 19-264,UNP residues 1107-1230
Chain G 19–264（246 aa） Fragment：UNP residues 19-264,UNP residues 1107-1230,UNP residues 19-264,UNP residues 1107-1230
Chain G 1107–1230（124 aa） Fragment：UNP residues 19-264,UNP residues 1107-1230,UNP residues 19-264,UNP residues 1107-1230
Not recorded CA CALCIUM ION × 6 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291.15 K；60mM sodium malonate PH5.0 6% w/v PEG3350
Resolution 4.21 Å R-free 0.254
5O35 Structure of complement proteins complex Deposited 2017-05-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 19–264（246 aa）
Chain C 1107–1231（125 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291.15 K；60mM Ammonium sulfate, 6% w/v PEG3350
Resolution 4.20 Å R-free 0.246
5WTB Complex Structure of Staphylococcus aureus SdrE with human complement factor H Deposited 2016-12-10 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1206–1226（21 aa） Fragment：UNP residues 1206-1226
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1M HEPES sodium pH 7.5, 0.2M Magnesium chloride, 30% PEG 400 (v/v)
Resolution 3.30 Å R-free 0.281
5WTB Complex Structure of Staphylococcus aureus SdrE with human complement factor H Deposited 2016-12-10 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1206–1226（21 aa） Fragment：UNP residues 1206-1226
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1M HEPES sodium pH 7.5, 0.2M Magnesium chloride, 30% PEG 400 (v/v)
Resolution 3.30 Å R-free 0.281
5WTB Complex Structure of Staphylococcus aureus SdrE with human complement factor H Deposited 2016-12-10 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1206–1226（21 aa） Fragment：UNP residues 1206-1226
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1M HEPES sodium pH 7.5, 0.2M Magnesium chloride, 30% PEG 400 (v/v)
Resolution 3.30 Å R-free 0.281
5WTB Complex Structure of Staphylococcus aureus SdrE with human complement factor H Deposited 2016-12-10 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 1206–1226（21 aa） Fragment：UNP residues 1206-1226
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1M HEPES sodium pH 7.5, 0.2M Magnesium chloride, 30% PEG 400 (v/v)
Resolution 3.30 Å R-free 0.281
6ZH1 Crystal structure of complex between FH19-20 and FhbA protein from Borrelia hermsii Deposited 2020-06-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1104–1231（128 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 SO4 SULFATE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.7；293.15 K；0.1 M MES pH6.7, 0.2 M Ammonium Sulfate, 20% (v/v) PEG 4000
Resolution 2.20 Å R-free 0.240
7WKI Structure of the ultra-affinity complex between CFH and a nanobody Deposited 2022-01-10 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1046–1231（186 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Sodium Phosphate monohydrate, 20% PEG 3350
Resolution 2.60 Å R-free 0.239
7ZJM Crystal structure of a complex between CspZ from Borrelia burgdorferi strain B408 and human FH SCR domains 6-7 Deposited 2022-04-11 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–444（124 aa）
Not recorded ZN ZINC ION × 7 IMD IMIDAZOLE × 4 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.2 M Zinc acetate 0.1 M imidazole (pH 7.4) 10% PEG 3000
Resolution 2.59 Å R-free 0.276
9F7I Crystal structure of Borrelia burgdorferi B31 CspZ in complex with human FH SCR6-7 Deposited 2024-05-03 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–444（124 aa）
Not recorded ZN ZINC ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；294 K；0.25 M ammonium sulfate 0.1 M MES pH 6.5 10% PEG 3000
Resolution 2.85 Å R-free 0.261
9MLU FbaA with Factor H 6-7 domain Deposited 2024-12-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 321–443（123 aa）
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；MES pH 6.0, Sodium chloride, PEG 6000, Ethylene Glycol
Resolution 1.82 Å R-free 0.276
9MLU FbaA with Factor H 6-7 domain Deposited 2024-12-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 321–443（123 aa）
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；MES pH 6.0, Sodium chloride, PEG 6000, Ethylene Glycol
Resolution 1.82 Å R-free 0.276
9MMU M5 protein with Factor H 6-7 domain Deposited 2024-12-20 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 321–443（123 aa）
Chain D 321–443（123 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；PEG 6000, Ethylene glycol, Sodium Chloride
Resolution 2.25 Å R-free 0.287
9MMU M5 protein with Factor H 6-7 domain Deposited 2024-12-20 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain G 321–443（123 aa）
Chain H 321–443（123 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；PEG 6000, Ethylene glycol, Sodium Chloride
Resolution 2.25 Å R-free 0.287
9MMX M6 protein with Factor H 6-7 domain Deposited 2024-12-20 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 321–443（123 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；PEG 6000, ethylene glycol, Sodium chloride
Resolution 1.90 Å R-free 0.302
9MMX M6 protein with Factor H 6-7 domain Deposited 2024-12-20 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 321–443（123 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；PEG 6000, ethylene glycol, Sodium chloride
Resolution 1.90 Å R-free 0.302

47 other PDB entries and 75 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CFAH_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–125； UniProt 1107–1231

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 2g7i

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 2g7i
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2. Structure Basics 2. Structure Basics

Entry ID entry_id2g7i
Deposition date deposition_date2006-02-28
Structure title titleStructure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for Atypical Hemolytic Uremic Syndrome
Keywords keywords;Sushi (CCP/SCR) domain, Complement, Regulator, Factor H, Beta-1H Globulin, Immune system, Atypical Hemolytic Uremic Syndrome, Heparin Binding ;; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier20.76 Å
Radius of gyration Rg (electron density) rg_electron20.66 Å
Forward intensity I(0) i03943160.00
Molecular weight molecular_weight13930.0 kDa
Excluded volume excluded_volume17267 ų
Envelope volume envelope_volume22275 ų
Hydration-shell volume shell_volume10626 ų
Envelope diameter envelope_diameter76.0 Å
Shell Rg shell_rg24.08 Å
Envelope Rg envelope_rg21.09 Å
Shape Rg shape_rg20.63 Å
Total Rg total_rg21.33 Å
Total atoms total_atoms976
Residues n_residues124
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax76.7 Å
Rg (real space) rg_real21.16 Å
Rg uncertainty (real space) rg_real_error0.83 Å
I(0) (real space) i0_real3.9430e+06
I(0) uncertainty (real space) i0_real_error6.0650e+04
Rg (reciprocal space) rg_reciprocal21.09 Å
I(0) (reciprocal space) i0_reciprocal3943000.0000
Solution quality estimate total_estimate0.6326
Solution quality rating solution_quality REASONABLE a REASONABLE solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary75.6 Å
Skewness Skewness skewness0.616
Kurtosis Kurtosis kurtosis-0.425
Angular range angular_range— – 0.3850 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha687800.0000
Real-space data points n_real_points70
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.369; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.112; Smooth: 0.000
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (2)

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7. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id2g7iA01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id2g7iA02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
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8. Citations (1)

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9. Files and Curves (10)