2vv5

The open structure of MscS

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL

ESCHERICHIA COLI

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 7	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MSCS_ECO57
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–286； UniProt 1–286 Author chain B； PDBConstruct 1–286； UniProt 1–286 Author chain C； PDBConstruct 1–286； UniProt 1–286 Author chain D； PDBConstruct 1–286； UniProt 1–286 Author chain E； PDBConstruct 1–286； UniProt 1–286 Author chain F； PDBConstruct 1–286； UniProt 1–286 Author chain G； PDBConstruct 1–286； UniProt 1–286

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2vv5
Deposition date deposition_date	2008-06-03
Structure title title	The open structure of MscS
Keywords keywords	;ION TRANSPORT, TRANSMEMBRANE, INNER MEMBRANE, MEMBRANE STRUCTURE, MEMBRANE PROTEIN, MEMBRANE, TRANSPORT, OPEN CHANNEL, IONIC CHANNEL ;; MEMBRANE PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2vv5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2vv5__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

2vv5__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	41.03 Å
Rg (electron density)	40.49 Å
Total Rg	41.02 Å
Atom count	13692
Residues	1799
Excluded volume	248230 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`2vv5__assembly_1__model_1`	heptameric （7）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 42 domains

SCOP 2.08 (21 domains)

Domain ID domain_id	d2vv5a1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5a2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5a3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5b1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5b2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5b3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5c1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5c2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5c3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5d1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5d2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5d3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5e1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5e2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5e3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5f1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5f2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5f3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

Domain ID domain_id	d2vv5g1
Class class	b — All beta proteins
Fold Fold fold	b.38 — Sm-like fold
Superfamily Superfamily superfamily	b.38.1 — Sm-like ribonucleoproteins
Family Family family	b.38.1.3 — Mechanosensitive channel protein MscS (YggB), middle domain

Domain ID domain_id	d2vv5g2
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.43 — Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family Family family	d.58.43.1 — Mechanosensitive channel protein MscS (YggB), C-terminal domain

Domain ID domain_id	d2vv5g3
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.34 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily Superfamily superfamily	f.34.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region
Family Family family	f.34.1.1 — Mechanosensitive channel protein MscS (YggB), transmembrane region

CATH v4.4 (21 domains)

Domain ID domain_id	2vv5A01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5A02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5A03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5B01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5B02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5B03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5C01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5C02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5C03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5D01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5D02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5D03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5E01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5E02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5E03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5F01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5F02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5F03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	2vv5G01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	1260 —

Domain ID domain_id	2vv5G02
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	30 — SH3 type barrels.
Homologous superfamily homologous superfamily	60 —

Domain ID domain_id	2vv5G03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	100 —

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Unit-cell length a length_a	230.880 Å
Unit-cell length b length_b	126.620 Å
Unit-cell length c length_c	123.220 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.42 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	28

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	3.450 Å
Low-resolution limit resolution_low	123.090 Å
R factor r_factor	0.2940
R_work r_work	0.2930
R_free r_free	0.3120

Description description	SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL
Molecular weight formula_weight	30951.0 kDa
Mutation mutation	YES
Source method src_method	man
Copy count entity_count	7

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G
Atom count atom_count	13692

The open structure of MscS

1. Protein Identity and Related Structures Protein Identity & Related Structures

SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2vv5__assembly_1__model_1

2vv5__assembly_1__model_1 | I(q)

2vv5__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 42 domains

SCOP 2.08 (21 domains)

CATH v4.4 (21 domains)

7. Citations (1)

Source organism organism	ESCHERICHIA COLI
NCBI taxonomy ID ncbi_taxonomy_id	562
Host organism host_organism	ESCHERICHIA COLI

The open structure of MscS

1. Protein Identity and Related Structures Protein Identity & Related Structures

SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2vv5__assembly_1__model_1

2vv5__assembly_1__model_1 | I(q)

2vv5__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 42 domains

SCOP 2.08 (21 domains)

CATH v4.4 (21 domains)

7. Citations (1)