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2vz8

Crystal Structure of Mammalian Fatty Acid Synthase

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

FATTY ACID SYNTHASE

OrganismNot specified

UniProt A5YV76

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
2vz8 2vz9

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name A5YV76_PIG
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–2512； UniProt 1–2512 Author chain B； PDBConstruct 1–2512； UniProt 1–2512

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2vz8
Deposition date deposition_date2008-07-31
Structure title titleCrystal Structure of Mammalian Fatty Acid Synthase
Keywords keywordsTRANSFERASE, PHOSPHOPANTETHEINE, FATTY ACID SYNTHASE, MULTIENZYME, MEGASYNTHASE, FATTY ACID SYNTHESIS; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2vz8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2vz8__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2vz8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）61.64 Å
Rg (electron density)61.66 Å
Total Rg61.76 Å
Atom count30281
Residues3966
Excluded volume538800 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2vz8__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (13 domains)

Domain ID domain_idd2vz8a1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.95 — Thiolase-like
Superfamily Superfamily superfamilyc.95.1 — Thiolase-like
Family Family familyc.95.1.1 — Thiolase-related
Domain ID domain_idd2vz8a2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.95 — Thiolase-like
Superfamily Superfamily superfamilyc.95.1 — Thiolase-like
Family Family familyc.95.1.1 — Thiolase-related
Domain ID domain_idd2vz8a3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamilyc.19.1 — FabD/lysophospholipase-like
Family Family familyc.19.1.1 — FabD-like
Domain ID domain_idd2vz8a4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamilyc.19.1 — FabD/lysophospholipase-like
Family Family familyc.19.1.1 — FabD-like
Domain ID domain_idd2vz8a5
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamilyd.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family familyd.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Domain ID domain_idd2vz8a6
Class classj — Peptides
Fold Fold foldj.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamilyj.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family familyj.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Domain ID domain_idd2vz8a7
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.38 — Thioesterase/thiol ester dehydrase-isomerase
Superfamily Superfamily superfamilyd.38.1 — Thioesterase/thiol ester dehydrase-isomerase
Family Family familyd.38.1.9 — Polyketide synthase dehydratase (PS-DH)-like
Domain ID domain_idd2vz8a8
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.38 — Thioesterase/thiol ester dehydrase-isomerase
Superfamily Superfamily superfamilyd.38.1 — Thioesterase/thiol ester dehydrase-isomerase
Family Family familyd.38.1.9 — Polyketide synthase dehydratase (PS-DH)-like
Domain ID domain_idd2vz8a9
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.62 — pseudo-methyltransferase domain from fatty acid synthase (FAS)
Domain ID domain_idd2vz8aa
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd2vz8ab
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd2vz8ac
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.2 — Tyrosine-dependent oxidoreductases
Domain ID domain_idd2vz8ad
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.2 — Tyrosine-dependent oxidoreductases

CATH v4.4 (11 domains)

Domain ID domain_id2vz8A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Thiolase/Chalcone synthase
Domain ID domain_id2vz8A03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
Domain ID domain_id2vz8A04
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology129 — Thiol Ester Dehydrase; Chain A
Homologous superfamily homologous superfamily110 — Polyketide synthase dehydratase
Domain ID domain_id2vz8A06
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id2vz8A07
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id2vz8B01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Thiolase/Chalcone synthase
Domain ID domain_id2vz8B02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily3290 —
Domain ID domain_id2vz8B03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
Domain ID domain_id2vz8B04
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology129 — Thiol Ester Dehydrase; Chain A
Homologous superfamily homologous superfamily110 — Polyketide synthase dehydratase
Domain ID domain_id2vz8B06
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id2vz8B07
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
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7. Citations (2)