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2wnu

Complex between c1q globular heads and heparan sulfate

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A

OrganismNot specified

UniProt P02745

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 3 其他Polymer 1 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B × 1 （P02746） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C × 1 （P02747） 2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose × 1 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B × 1 （P02746） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C × 1 （P02747） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1pk6 2jg8 2jg8 2jg9 2jg9 2wnu 2wnu 2wnv 2wnv 5hkj 5hzf 6fcz

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name C1QA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–134； UniProt 112–245 Author chain D； PDBConstruct 1–134； UniProt 112–245

COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B

OrganismNot specified

UniProt P02746

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 3 其他Polymer 1 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A × 1 （P02745） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C × 1 （P02747） 2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose × 1 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A × 1 （P02745） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C × 1 （P02747） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1pk6 2jg8 2jg8 2jg9 2jg9 2wnu 2wnu 2wnv 2wnv 5hkj 5hzf 6fcz

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name C1QB_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–136； UniProt 116–251 Author chain E； PDBConstruct 1–136； UniProt 116–251

COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C

OrganismNot specified

UniProt P02747

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 3 其他Polymer 1 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A × 1 （P02745） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B × 1 （P02746） 2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose × 1 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A × 1 （P02745） COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B × 1 （P02746） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1pk6 2jg8 2jg8 2jg9 2jg9 2wnu 2wnu 2wnv 2wnv 5hkj 5hzf 6fcz

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name C1QC_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–131； UniProt 115–245 Author chain F； PDBConstruct 1–131； UniProt 115–245

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2wnu
Deposition date deposition_date2009-07-20
Structure title titleComplex between c1q globular heads and heparan sulfate
Keywords keywords;COLLAGEN, INNATE IMMUNITY, IMMUNE RESPONSE, PYRROLIDONE CARBOXYLIC ACID, IMMUNE SYSTEM, DISEASE MUTATION, COMPLEMENT PATHWAY, GLYCOPROTEIN, HYDROXYLATION ;; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2wnu__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2wnu__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2wnu__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.01 Å
Rg (electron density)19.51 Å
Total Rg20.61 Å
Atom count3143
Residues395
Excluded volume55701 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2wnu__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2wnu__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd2wnua_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like
Domain ID domain_idd2wnub_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like
Domain ID domain_idd2wnuc_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like
Domain ID domain_idd2wnud_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like
Domain ID domain_idd2wnue_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like
Domain ID domain_idd2wnuf_
Class classb — All beta proteins
Fold Fold foldb.22 — TNF-like
Superfamily Superfamily superfamilyb.22.1 — TNF-like
Family Family familyb.22.1.1 — TNF-like

CATH v4.4 (6 domains)

Domain ID domain_id2wnuA00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2wnuB00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2wnuC00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2wnuD00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2wnuE00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2wnuF00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily40 —
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7. Citations (1)