2xwj

Crystal Structure of Complement C3b in Complex with Factor B

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

COMPLEMENT C3 BETA CHAIN

物种未注明

UniProt P01024

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT FACTOR B × 1 (P00751) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT FACTOR B × 1 (P00751) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT FACTOR B × 1 (P00751) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT FACTOR B × 1 (P00751) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CO3_HUMAN
Isoform —
PDB实体 1, 2
链与序列区间 作者链 A; PDB构建体 1–645; UniProt 23–667 作者链 C; PDB构建体 1–645; UniProt 23–667 作者链 E; PDB构建体 1–645; UniProt 23–667 作者链 G; PDB构建体 1–645; UniProt 23–667 作者链 B; PDB构建体 1–915; UniProt 749–1663 作者链 D; PDB构建体 1–915; UniProt 749–1663 作者链 F; PDB构建体 1–915; UniProt 749–1663 作者链 H; PDB构建体 1–915; UniProt 749–1663

COMPLEMENT FACTOR B

HOMO SAPIENS

UniProt P00751

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT C3 BETA CHAIN × 1 (P01024) COMPLEMENT C3 ALPHA CHAIN × 1 (P01024) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT C3 BETA CHAIN × 1 (P01024) COMPLEMENT C3 ALPHA CHAIN × 1 (P01024) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT C3 BETA CHAIN × 1 (P01024) COMPLEMENT C3 ALPHA CHAIN × 1 (P01024) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 1 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 3 COMPLEMENT C3 BETA CHAIN × 1 (P01024) COMPLEMENT C3 ALPHA CHAIN × 1 (P01024) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NICKEL (II) ION × 1 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CFAB_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 I; PDB构建体 1–739; UniProt 26–764 作者链 J; PDB构建体 1–739; UniProt 26–764 作者链 K; PDB构建体 1–739; UniProt 26–764 作者链 L; PDB构建体 1–739; UniProt 26–764

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2xwj
沉积日期 deposition_date2010-11-04
结构标题 titleCrystal Structure of Complement C3b in Complex with Factor B
关键词 keywordsIMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY; HYDROLASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2xwj__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2xwj__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2xwj__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)46.20 Å
Rg(电子密度)45.98 Å
总 Rg46.21 Å
原子数17811
残基数2253
排除体积317250 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2xwj__assembly_1__model_1 trimeric (3) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2xwj__assembly_2__model_1 trimeric (3) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2xwj__assembly_3__model_1 trimeric (3) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 2xwj__assembly_4__model_1 trimeric (3) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (6)

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6. 折叠分类 (SCOP + CATH) 56 domains

CATH v4.4 (56 domains)

结构域编号 domain_id2xwjA01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjA02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjA03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1940 —
结构域编号 domain_id2xwjA04
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjA05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjA06
类 Class class6 — Special
架构 Architecture architecture20 — Other non-globular
拓扑 Topology topology50 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily160 —
结构域编号 domain_id2xwjB01
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology130 — S-adenosyl-L-methionine-dependent methyltransferases
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjB02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjB03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology120 — Jelly Rolls
同源超家族 H-superfamily homologous superfamily1540 —
结构域编号 domain_id2xwjB04
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjB05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily690 — Alpha-macroglobulin, receptor-binding domain
结构域编号 domain_id2xwjB06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2xwjC01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjC02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjC03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1940 —
结构域编号 domain_id2xwjC04
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjC05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjC06
类 Class class6 — Special
架构 Architecture architecture20 — Other non-globular
拓扑 Topology topology50 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily160 —
结构域编号 domain_id2xwjD01
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology130 — S-adenosyl-L-methionine-dependent methyltransferases
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjD02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjD03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology120 — Jelly Rolls
同源超家族 H-superfamily homologous superfamily1540 —
结构域编号 domain_id2xwjD04
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjD05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily690 — Alpha-macroglobulin, receptor-binding domain
结构域编号 domain_id2xwjD06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2xwjE01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjE02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjE03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1940 —
结构域编号 domain_id2xwjE04
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjE05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjE06
类 Class class6 — Special
架构 Architecture architecture20 — Other non-globular
拓扑 Topology topology50 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily160 —
结构域编号 domain_id2xwjF01
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology130 — S-adenosyl-L-methionine-dependent methyltransferases
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjF02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjF03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology120 — Jelly Rolls
同源超家族 H-superfamily homologous superfamily1540 —
结构域编号 domain_id2xwjF04
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjF05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily690 — Alpha-macroglobulin, receptor-binding domain
结构域编号 domain_id2xwjF06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2xwjG01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjG02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjG03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1940 —
结构域编号 domain_id2xwjG04
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjG05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily1930 — Macroglobulin (MG2) domain
结构域编号 domain_id2xwjG06
类 Class class6 — Special
架构 Architecture architecture20 — Other non-globular
拓扑 Topology topology50 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily160 —
结构域编号 domain_id2xwjH01
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology130 — S-adenosyl-L-methionine-dependent methyltransferases
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjH02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2xwjH03
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology120 — Jelly Rolls
同源超家族 H-superfamily homologous superfamily1540 —
结构域编号 domain_id2xwjH04
类 Class class1 — Mainly Alpha
架构 Architecture architecture50 — Alpha/alpha barrel
拓扑 Topology topology10 — Glycosyltransferase
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id2xwjH05
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily690 — Alpha-macroglobulin, receptor-binding domain
结构域编号 domain_id2xwjH06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2xwjI01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2xwjI03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily410 — von Willebrand factor, type A domain
结构域编号 domain_id2xwjJ01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2xwjJ03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily410 — von Willebrand factor, type A domain
结构域编号 domain_id2xwjK01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2xwjK03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily410 — von Willebrand factor, type A domain
结构域编号 domain_id2xwjL01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2xwjL03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily410 — von Willebrand factor, type A domain
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7. 引用文献 (1)