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2zw3

Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Gap junction beta-2 protein

Homo sapiens

UniProt P29033

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 12 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5kj3 5kjg

2 assemblies

Homodimer
7qeo 7qes 7qeu 7qev

4 assemblies

Homotetramer

None

Other homooligomers
2zw3 3iz1 3iz2 5er7 5era 5era 6uvr 6uvs 6uvt 7qeq 7qer 7qet

18 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CXB2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–226； UniProt 1–226 Author chain B； PDBConstruct 1–226； UniProt 1–226 Author chain C； PDBConstruct 1–226； UniProt 1–226 Author chain D； PDBConstruct 1–226； UniProt 1–226 Author chain E； PDBConstruct 1–226； UniProt 1–226 Author chain F； PDBConstruct 1–226； UniProt 1–226

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2zw3
Deposition date deposition_date2008-12-01
Structure title titleStructure of the connexin-26 gap junction channel at 3.5 angstrom resolution
Keywords keywords;ION CHANNEL, alpha helical membrane channel, two double layered lipid spanning, cellular adhesion, Cell junction, Cell membrane, Deafness, Disease mutation, Ectodermal dysplasia, Gap junction, Hearing, Ichthyosis, Membrane, Non-syndromic deafness, Palmoplantar keratoderma, Polymorphism, Transmembrane, CELL ADHESION ;; CELL ADHESION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2zw3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2zw3__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2zw3__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）48.31 Å
Rg (electron density)49.39 Å
Total Rg49.35 Å
Atom count19668
Residues2412
Excluded volume358510 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2zw3__assembly_1__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id2zw3A00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id2zw3B00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id2zw3C00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id2zw3D00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id2zw3E00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id2zw3F00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
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7. Citations (1)