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3bla

Synthetic Gene Encoded DcpS bound to inhibitor DG153249

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Scavenger mRNA-decapping enzyme DcpS

Homo sapiens

UniProt Q96C86

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1st0 1st4 3bl7 3bl9 3bla 4qde 4qde 4qdv 4qdv 4qeb 4qeb 5osy

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name DCPS_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–301； UniProt 38–337 Author chain B； PDBConstruct 2–301； UniProt 38–337

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3bla
Deposition date deposition_date2007-12-10
Structure title titleSynthetic Gene Encoded DcpS bound to inhibitor DG153249
Keywords keywords;MRNA DECAPPING ENZYME, DCPS, LIGAND COMPLEX, Cytoplasm, Hydrolase, Nonsense-mediated mRNA decay, Nucleus, Polymorphism, Structural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D ;; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3bla__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3bla__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3bla__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.20 Å
Rg (electron density)24.99 Å
Total Rg25.87 Å
Atom count4799
Residues575
Excluded volume85453 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3bla__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 9 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd3blaa1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.13 — HIT-like
Superfamily Superfamily superfamilyd.13.1 — HIT-like
Family Family familyd.13.1.3 — mRNA decapping enzyme DcpS C-terminal domain
Domain ID domain_idd3blaa2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.246 — mRNA decapping enzyme DcpS N-terminal domain
Superfamily Superfamily superfamilyd.246.1 — mRNA decapping enzyme DcpS N-terminal domain
Family Family familyd.246.1.1 — mRNA decapping enzyme DcpS N-terminal domain
Domain ID domain_idd3blab1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.13 — HIT-like
Superfamily Superfamily superfamilyd.13.1 — HIT-like
Family Family familyd.13.1.3 — mRNA decapping enzyme DcpS C-terminal domain
Domain ID domain_idd3blab2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.246 — mRNA decapping enzyme DcpS N-terminal domain
Superfamily Superfamily superfamilyd.246.1 — mRNA decapping enzyme DcpS N-terminal domain
Family Family familyd.246.1.1 — mRNA decapping enzyme DcpS N-terminal domain

CATH v4.4 (5 domains)

Domain ID domain_id3blaA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily40 — Scavenger mRNA decapping enzyme, N-terminal domain
Domain ID domain_id3blaA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology428 — HIT family, subunit A
Homologous superfamily homologous superfamily10 — HIT-like
Domain ID domain_id3blaB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily40 — Scavenger mRNA decapping enzyme, N-terminal domain
Domain ID domain_id3blaB02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology2240 — mRNA decapping enzyme DcpS N-terminal fold
Homologous superfamily homologous superfamily10 — mRNA decapping enzyme DcpS N-terminal domain
Domain ID domain_id3blaB03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology428 — HIT family, subunit A
Homologous superfamily homologous superfamily10 — HIT-like
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7. Citations (1)