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3d24

Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Steroid hormone receptor ERR1

Homo sapiens

UniProt P11474

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha × 2 （Q9UBK2） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha × 1 （Q9UBK2） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha × 1 （Q9UBK2） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3k6p

1 assemblies

Homodimer
3k6p

1 assemblies

Homotetramer

None

Other homooligomers
2pjl

1 assemblies

Heteromeric or nucleic-acid complex
1xb7 3d24 3d24 3d24 7e2e

5 assemblies

View Construct and Data Evidence
UniProt name ERR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 22–253； UniProt 288–519 Author chain C； PDBConstruct 22–253； UniProt 288–519

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

OrganismNot specified

UniProt Q9UBK2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Steroid hormone receptor ERR1 × 2 （P11474） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Steroid hormone receptor ERR1 × 1 （P11474） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Steroid hormone receptor ERR1 × 1 （P11474） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1xb7 3b1m 3cs8 3d24 3d24 3d24 3u9q 3v9t 3v9v 4qjr 4qk4 5z5s

45 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PRGC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–22； UniProt 198–219 Author chain D； PDBConstruct 1–22； UniProt 198–219

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3d24
Deposition date deposition_date2008-05-07
Structure title titleCrystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)
Keywords keywords;nuclear receptor, ligand binding domain, coactivator, DNA-binding, Metal-binding, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Zinc, Zinc-finger, Polymorphism, RNA-binding, Structural Genomics, Structural Proteomics in Europe, SPINE ;; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3d24__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3d24__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3d24__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.01 Å
Rg (electron density)21.83 Å
Total Rg22.74 Å
Atom count3518
Residues452
Excluded volume63568 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3d24__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3d24__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3d24__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd3d24a1
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain
Domain ID domain_idd3d24c1
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain

CATH v4.4 (2 domains)

Domain ID domain_id3d24A00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology565 — Retinoid X Receptor
Homologous superfamily homologous superfamily10 — Retinoid X Receptor
Domain ID domain_id3d24C00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology565 — Retinoid X Receptor
Homologous superfamily homologous superfamily10 — Retinoid X Receptor
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7. Citations (1)