← Back to search
3eob

Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Integrin alpha-L

Homo sapiens

UniProt P20701

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Efalizumab Fab fragment, light chain × 1 Efalizumab Fab fragment, heavy chain × 1 ZINC ION × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Efalizumab Fab fragment, light chain × 1 Efalizumab Fab fragment, heavy chain × 1 ZINC ION × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cqp 1cqp 1dgq 1mjn 1mq9 1mqa 1rd4 1rd4 1rd4 1rd4 1xdd 1xdd

40 assemblies; showing the first 12

Homodimer
1lfa 1zoo 1zop 3bqm 3bqn 3e2m 4ixd

7 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1mq8 1mq8 1t0p 3bn3 3eoa 3eoa 3eob 3eob 3hi6 3hi6 3hi6 3tcx

38 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ITAL_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain I； PDBConstruct 1–181； UniProt 153–333 Author chain J； PDBConstruct 1–181； UniProt 153–333

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id3eob
Deposition date deposition_date2008-09-26
Structure title titleCrystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II
Keywords keywords;Efalizumab, Fab, antibody, LFA-1, CD11a, I domain, Alternative splicing, Calcium, Cell adhesion, Glycoprotein, Integrin, Magnesium, Membrane, Polymorphism, Receptor, Transmembrane, IMMUNE SYSTEM-CELL ADHESION COMPLEX ;; IMMUNE SYSTEM/CELL ADHESION
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3eob__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3eob__assembly_2__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3eob__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）30.72 Å
Rg (electron density)30.49 Å
Total Rg31.03 Å
Atom count4727
Residues608
Excluded volume84180 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3eob__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3eob__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 10 domains

CATH v4.4 (10 domains)

Domain ID domain_id3eobA01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobA02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobB01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobB02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobH01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobH02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobI00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id3eobJ00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily410 — von Willebrand factor, type A domain
Domain ID domain_id3eobL01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3eobL02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
▶

7. Citations (1)