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3iec

Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine/threonine-protein kinase MARK2

Homo sapiens

UniProt Q7KZI7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Cytotoxicity-associated immunodominant antigen × 1 （P55980） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Cytotoxicity-associated immunodominant antigen × 1 （P55980） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Cytotoxicity-associated immunodominant antigen × 1 （P55980） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Cytotoxicity-associated immunodominant antigen × 1 （P55980） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5eak 5eak 5kz7 5kz7 5kz8 5kz8 8txy 8txy

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3iec 3iec 3iec 3iec

4 assemblies

View Construct and Data Evidence
UniProt name MARK2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–319； UniProt 49–363 Author chain B； PDBConstruct 5–319； UniProt 49–363 Author chain C； PDBConstruct 5–319； UniProt 49–363 Author chain D； PDBConstruct 5–319； UniProt 49–363

Cytotoxicity-associated immunodominant antigen

Helicobacter pylori

UniProt P55980

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase MARK2 × 1 （Q7KZI7） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase MARK2 × 1 （Q7KZI7） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase MARK2 × 1 （Q7KZI7） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase MARK2 × 1 （Q7KZI7） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4dvy 4dvz 4g0h

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3iec 3iec 3iec 3iec 4irv 4irv 4irv 4irv

8 assemblies

View Construct and Data Evidence
UniProt name CAGA_HELPY
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 5–125； UniProt 885–1005 Author chain F； PDBConstruct 5–125； UniProt 885–1005 Author chain G； PDBConstruct 5–125； UniProt 885–1005 Author chain H； PDBConstruct 5–125； UniProt 885–1005

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3iec
Deposition date deposition_date2009-07-22
Structure title titleHelicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates
Keywords keywords;Protein-protein complex, kinase, virulence factor, Alternative promoter usage, ATP-binding, Cell membrane, Developmental protein, Differentiation, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN-TOXIN COMPLEX ;; SIGNALING PROTEIN/TOXIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3iec__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3iec__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3iec__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.10 Å
Rg (electron density)20.96 Å
Total Rg21.96 Å
Atom count2653
Residues325
Excluded volume47776 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3iec__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3iec__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3iec__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 3iec__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd3ieca_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd3iecb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd3iecc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd3iecd_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches

CATH v4.4 (12 domains)

Domain ID domain_id3iecA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id3iecA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3iecA03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
Domain ID domain_id3iecB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id3iecB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3iecB03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
Domain ID domain_id3iecC01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id3iecC02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3iecC03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
Domain ID domain_id3iecD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id3iecD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3iecD03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
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7. Citations (1)