Maltose-binding periplasmic protein, HUNTINGTIN FUSION PROTEIN
Escherichia coli K-12, Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Insufficient information Homooligomer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count | Chain A； UniProt 27–384 Chain B； UniProt 27–384 Chain C； UniProt 27–384 | Fragment：FUSION PROTEIN, SEE REMARK 999 | ZN ZINC ION × 5 CA CALCIUM ION × 9 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.2；pH 7.2, VAPOR DIFFUSION, HANGING DROP | Resolution 3.70 Å R-free 0.293 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 3IO6 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1HSJ SARR MBP FUSION STRUCTURE Deposited 2000-12-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–387（361 aa）
Chain B
27–387（361 aa）
|
Not recorded | GLC alpha-D-glucopyranose × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.304 |
| 2V93 EQUILLIBRIUM MIXTURE OF OPEN AND PARTIALLY-CLOSED SPECIES IN THE APO STATE OF MALTODEXTRIN-BINDING PROTEIN BY PARAMAGNETIC RELAXATION ENHANCEMENT NMR Deposited 2007-08-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–396（370 aa）
|
Mutation：YES | MXT 1-(1-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)PYRROLIDINE-2,5-DIONE × 2 |
SOLUTION NMR
NMR measurement conditions
pH 7.4；310 K；Ionic strength (raw mmCIF value) 0MM NACL；Pressure 1.0
NMR sample composition
10MM TRIS-HCL
|
Resolution not provided |
| 3IO4 Huntingtin amino-terminal region with 17 Gln residues - Crystal C90 Deposited 2009-08-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
27–384（358 aa）
Fragment：Fusion protein, see remark 999
Chain B
27–384（358 aa）
Fragment：Fusion protein, see remark 999
Chain C
27–384（358 aa）
Fragment：Fusion protein, see remark 999
|
Not recorded | ZN ZINC ION × 8 CA CALCIUM ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；12% polyethylene glycol, 200 mM Zn Acetate, 200 mM Sodium Acetate, 100 mM Sodium Cacodylate pH 6.5 to 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.63 Å R-free 0.304 |
| 3OSQ Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 175 Deposited 2010-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–199（173 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
Chain A
200–396（197 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；296 K；0.5 M Ammonium sulfate, 0.1M Sodium citrate tribasic dihydrate pH 5.6, 1.0 M Lithium sulfate monohydrate, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 1.90 Å R-free 0.199 |
| 3OSR Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 311 Deposited 2010-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–337（311 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
Chain A
338–396（59 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；296 K；0.1 M Sodium acetate pH 4.6, 8% w/v polyethylene glycol 4000, VAPOR DIFFUSION, temperature 296K
|
Resolution 2.00 Å R-free 0.226 |
| 3OSR Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 311 Deposited 2010-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–337（311 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
Chain B
338–396（59 aa）
Fragment：GFP P42212 residues 2-146, 147-238, MBP P0AEX9 residues 27-199, 201-396
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.6；296 K；0.1 M Sodium acetate pH 4.6, 8% w/v polyethylene glycol 4000, VAPOR DIFFUSION, temperature 296K
|
Resolution 2.00 Å R-free 0.226 |
| 3VD8 Crystal structure of human AIM2 PYD domain with MBP fusion Deposited 2012-01-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
Fragment：PYD domain (UNP Residues 1-107)
|
Mutation：D82A, K83A, E172A, N173A, K239A | EDO 1,2-ETHANEDIOL × 4 K POTASSIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；20% PEG3350, 0.1M Potassium Acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.07 Å R-free 0.221 |
| 4FEB Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta) Deposited 2012-05-29 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
27–384（358 aa）
Chain B
27–384（358 aa）
Chain C
27–384（358 aa）
|
Mutation：HQHQH Mutation：HQHQH Mutation：HQHQH | ZN ZINC ION × 38 NA SODIUM ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
hanging drop；pH 6.5；278 K；PEG12K, Na Acetate, Zn Acetate, Na Cacodylate, pH 6.5, hanging drop, temperature 278K
|
Resolution 2.80 Å R-free 0.275 |
| 4MY2 Crystal Structure of Norrin in fusion with Maltose Binding Protein Deposited 2013-09-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
26–392（367 aa）
Fragment：Maltose binding protein (UNP residues 26-392), Norrin (UNP residues 30-133) fusion protein
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；15% PEG 3350, 0.1 M sodium acetate, pH 4.6, 0.2 M ammonium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.237 |
| 4WGI A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) Deposited 2014-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：unp residues 27-392,unp residues 173-291
|
Mutation：K194A, K197A, R201A | 3M6 (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid × 1 MG MAGNESIUM ION × 1 FMT FORMIC ACID × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；10 MG/ML MBP-MCL1 VCID 9272, 200MM MG FORMATE, 20% PEG3350, 0.5M BRD-0611, 1MM MALTOSE, CRYOPROTECTANT 20% ETHYLENE GLYCOL
|
Resolution 1.85 Å R-free 0.213 |
| 4WRN Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein Deposited 2014-10-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–393（367 aa）
Chain B
27–393（367 aa）
|
Mutation：;I28T, D108A, K109A, E198A, N199A, A241H, K245H, K265A, A338V, I343V, E385A, E388A, D389A, R393N,R586A, R588A,I28T, D108A, K109A, E198A, N199A, A241H, K245H, K265A, A338V, I343V, E385A, E388A, D389A, R393N,R586A, R588A ; Mutation：;I28T, D108A, K109A, E198A, N199A, A241H, K245H, K265A, A338V, I343V, E385A, E388A, D389A, R393N,R586A, R588A,I28T, D108A, K109A, E198A, N199A, A241H, K245H, K265A, A338V, I343V, E385A, E388A, D389A, R393N,R586A, R588A ; | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.2；293 K；Sodium/potassium tartrate, Tris-HCl
|
Resolution 3.20 Å R-free 0.246 |
| 4WTH Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic) Deposited 2014-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：MBP residues 27-392 (UNP) + Ataxin-3 C-terminal region (UNP residues 278-324)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；24% PEG5000 MME, 0.9 M sodium acetate, 0.06 M imidazole, pH 8.0, 0.1 M zinc acetate
|
Resolution 2.25 Å R-free 0.250 |
| 4WTH Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic) Deposited 2014-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
Fragment：MBP residues 27-392 (UNP) + Ataxin-3 C-terminal region (UNP residues 278-324)
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；24% PEG5000 MME, 0.9 M sodium acetate, 0.06 M imidazole, pH 8.0, 0.1 M zinc acetate
|
Resolution 2.25 Å R-free 0.250 |
| 4WVG Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB). Deposited 2014-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
33–392（360 aa）
Fragment：UNP RESIDUES 33-393, UNP RESIDUES 26-191
|
Mutation：S36A, R393N | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；12 % PEG 8000, 20 % ethylene glycol, 0.2 M amino acids mix (0.2 M sodium-L-glutamate, 0.2 M DL-alanine, 0.2 M glycine, 0.2 M DL-lysine, 0.2 M DL-serine), 100 mM Tris.Cl pH 8.5
|
Resolution 2.05 Å R-free 0.242 |
| 4WVH Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep1). Deposited 2014-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
33–392（360 aa）
Fragment：unp residues 33-382, unp reisdues 26-175
|
Mutation：K143G, Q78C,K143G, Q78C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；296 K；12 % PEG 8000, 20 % ethylene glycol, 100 mM sodium acetate pH 5.3 - 5.5
|
Resolution 2.10 Å R-free 0.248 |
| 4WVI Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep2). Deposited 2014-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
33–392（360 aa）
Fragment：unp residues 33-393, unp residues 26-175
|
Mutation：K143G, Q78C, R393N | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；290 K；12 % PEG 8000, 20 % ethylene glycol, 100 mM sodium acetate pH 5.3 - 5.5
|
Resolution 1.90 Å R-free 0.219 |
| 4WVJ Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with an inhibitor peptide (pep3). Deposited 2014-11-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
33–392（360 aa）
Fragment：UNP RESIDUES 33-393, unp residues 26-175
|
Mutation：K143G, Q78C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；290 K；12 % PEG 8000, 20 % ethylene glycol, 100 mM sodium acetate pH 5.3 - 5.5
|
Resolution 1.95 Å R-free 0.229 |
| 4XA2 Structure of the Major Type IV pilin of Acinetobacter baumannii Deposited 2014-12-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–393（367 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；0.1M Bis-Tris, 22.5% PEG 3350, 0.3M 1,6 Hexandediol
|
Resolution 1.98 Å R-free 0.241 |
| 4XA2 Structure of the Major Type IV pilin of Acinetobacter baumannii Deposited 2014-12-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–393（367 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；0.1M Bis-Tris, 22.5% PEG 3350, 0.3M 1,6 Hexandediol
|
Resolution 1.98 Å R-free 0.241 |
| 4XAI Crystal Structure of red flour beetle NR2E1/TLX Deposited 2014-12-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
27–392（366 aa）
Fragment：maltose binding protein fused ligand binding domain,maltose binding protein fused ligand binding domain
Chain B
27–392（366 aa）
Fragment：maltose binding protein fused ligand binding domain,maltose binding protein fused ligand binding domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.4；298 K；PEG 3350
|
Resolution 2.60 Å R-free 0.262 |
| 4XAJ Crystal structure of human NR2E1/TLX Deposited 2014-12-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
26–392（367 aa）
Fragment：maltose binding protein fused ligand binding domain
Chain C
26–392（367 aa）
Fragment：maltose binding protein fused ligand binding domain
|
Mutation：K257R, N259T, K260L, C338V,K257R, N259T, K260L, C338V Mutation：K257R, N259T, K260L, C338V,K257R, N259T, K260L, C338V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；PEG3350
|
Resolution 3.55 Å R-free 0.314 |
| 4XAJ Crystal structure of human NR2E1/TLX Deposited 2014-12-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
26–392（367 aa）
Fragment：maltose binding protein fused ligand binding domain
Chain D
26–392（367 aa）
Fragment：maltose binding protein fused ligand binding domain
|
Mutation：K257R, N259T, K260L, C338V,K257R, N259T, K260L, C338V Mutation：K257R, N259T, K260L, C338V,K257R, N259T, K260L, C338V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；PEG3350
|
Resolution 3.55 Å R-free 0.314 |
| 4XHS Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction Deposited 2015-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392, UNP P59046 residues 10-106
Chain B
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392, UNP P59046 residues 10-106
|
Not recorded | FMT FORMIC ACID × 4 NA SODIUM ION × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；3.5 M Sodium Formate, 0.1 M Sodium Acetate pH 4.6
|
Resolution 1.70 Å R-free 0.190 |
| 4YS9 Ataxin-3 Carboxy-Terminal Region - Crystal C1 (tetragonal) Deposited 2015-03-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
Fragment：MBP residues 27-392 (UNP) + Ataxin-3 C-terminal region (UNP residues 278-324)
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；278 K；25% PEG5000 MME, 1.0 M sodium acetate, 0.1 M imidazole, pH 8.0, 0.1 M zinc acetate
|
Resolution 2.00 Å R-free 0.223 |
| 5BJZ Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody Deposited 2017-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
26–393（368 aa）
|
Not recorded | GOL GLYCEROL × 3 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；0.1 M HEPES: pH 7.0 and 15% PEG4000
|
Resolution 1.95 Å R-free 0.229 |
| 5BJZ Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody Deposited 2017-09-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
26–393（368 aa）
|
Not recorded | GOL GLYCEROL × 2 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；0.1 M HEPES: pH 7.0 and 15% PEG4000
|
Resolution 1.95 Å R-free 0.229 |
| 5BMY Crystal structure of hPin1 WW domain (5-21) fused with maltose-binding protein Deposited 2015-05-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–393（367 aa）
|
Mutation：R393N | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；2.1 M DL-malic acid
|
Resolution 2.00 Å R-free 0.194 |
| 5C7R Revealing surface waters on an antifreeze protein by fusion protein crystallography Deposited 2015-06-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
Fragment：UNP P0AEY0 residues 27-384, UNP P19614 residues 1-63
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.4；298 K；1.75 M (NH4)2SO4, 100 mM NaOAC (pH 4.4)
|
Resolution 1.94 Å R-free 0.234 |
| 5C7R Revealing surface waters on an antifreeze protein by fusion protein crystallography Deposited 2015-06-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–384（358 aa）
Fragment：UNP P0AEY0 residues 27-384, UNP P19614 residues 1-63
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.4；298 K；1.75 M (NH4)2SO4, 100 mM NaOAC (pH 4.4)
|
Resolution 1.94 Å R-free 0.234 |
| 5CL1 Complex structure of Norrin with human Frizzled 4 Deposited 2015-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
26–392（367 aa）
Fragment：UNP Q00604 residues 31-133
Chain B
26–392（367 aa）
Fragment：UNP Q00604 residues 31-133
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；200 mM ammonium sulfate, 100 mM sodium cacodylate trihydrate (pH 6.5), 15% w/v polyethylene glycol 8,000
|
Resolution 3.80 Å R-free 0.310 |
| 5DFM Structure of Tetrahymena telomerase p19 fused to MBP Deposited 2015-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
|
Not recorded | SO4 SULFATE ION × 5 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；12 mg/ml MBP-P19 protein, 0.1 M Sodium Acetate, 2.0 M Ammonium Sulfate
|
Resolution 2.30 Å R-free 0.226 |
| 5DFM Structure of Tetrahymena telomerase p19 fused to MBP Deposited 2015-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–384（358 aa）
|
Not recorded | SO4 SULFATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；12 mg/ml MBP-P19 protein, 0.1 M Sodium Acetate, 2.0 M Ammonium Sulfate
|
Resolution 2.30 Å R-free 0.226 |
| 5DFM Structure of Tetrahymena telomerase p19 fused to MBP Deposited 2015-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
27–384（358 aa）
Chain B
27–384（358 aa）
|
Not recorded | SO4 SULFATE ION × 45 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；12 mg/ml MBP-P19 protein, 0.1 M Sodium Acetate, 2.0 M Ammonium Sulfate
|
Resolution 2.30 Å R-free 0.226 |
| 5E24 Structure of the Su(H)-Hairless-DNA Repressor Complex Deposited 2015-09-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
27–396（370 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, N367R | EDO 1,2-ETHANEDIOL × 73 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 8；277 K；Tris, PEG3350, (NH4)2SO4
|
Resolution 2.14 Å R-free 0.193 |
| 5E24 Structure of the Su(H)-Hairless-DNA Repressor Complex Deposited 2015-09-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein–DNA Heteromer；Protein × 3 PDB declaration: pentameric |
Chain C
27–396（370 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, N367R | EDO 1,2-ETHANEDIOL × 40 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 8；277 K；Tris, PEG3350, (NH4)2SO4
|
Resolution 2.14 Å R-free 0.193 |
| 5E24 Structure of the Su(H)-Hairless-DNA Repressor Complex Deposited 2015-09-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein–DNA Heteromer；Protein × 6 PDB declaration: octameric |
Chain A
27–396（370 aa）
Chain C
27–396（370 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, N367R Mutation：D82A, K83A, E172A, N173A, K239A, N367R | EDO 1,2-ETHANEDIOL × 113 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 8；277 K；Tris, PEG3350, (NH4)2SO4
|
Resolution 2.14 Å R-free 0.193 |
| 5E7U MBP-MamC loop structure, a magnetite biomineralizing protein from Magnetospirillium magneticum AMB-1 Deposited 2015-10-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–389（363 aa）
Chain A
390–392（3 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M sodium acetate ,
2 M Ammonium sulfate
|
Resolution 2.80 Å R-free 0.307 |
| 5EDU Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A Deposited 2015-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
Fragment：MBP + HD6 catalytic domain 2 (UNP residues 479-835)
|
Not recorded | TSN TRICHOSTATIN A × 1 ZN ZINC ION × 1 K POTASSIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M potassium sodium tartrate, 20% PEG3350
|
Resolution 2.79 Å R-free 0.275 |
| 5EDU Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A Deposited 2015-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：MBP + HD6 catalytic domain 2 (UNP residues 479-835)
|
Not recorded | TSN TRICHOSTATIN A × 1 ZN ZINC ION × 1 K POTASSIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M potassium sodium tartrate, 20% PEG3350
|
Resolution 2.79 Å R-free 0.275 |
| 5FIO DARPins as a new tool for experimental phasing in protein crystallography Deposited 2015-09-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
29–392（364 aa）
Fragment：UNP RESIDUES 29-392
|
Not recorded | HG MERCURY (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；30.55% W/V PEG 6000, 0.1M TRIS-CL, PH 8.0
|
Resolution 2.10 Å R-free 0.253 |
| 5GPP Crystal structure of zebrafish ASC PYD domain Deposited 2016-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
Fragment：UNP residues 27-384,UNP residues 3-88
|
Mutation：D83A,K84A,E173A,N174A,K240A | SO4 SULFATE ION × 2 ACT ACETATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；20% PEG2000MME, 0.1 M NaAcO
|
Resolution 2.00 Å R-free 0.252 |
| 5GPP Crystal structure of zebrafish ASC PYD domain Deposited 2016-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–384（358 aa）
Fragment：UNP residues 27-384,UNP residues 3-88
|
Mutation：D83A,K84A,E173A,N174A,K240A | SO4 SULFATE ION × 3 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；20% PEG2000MME, 0.1 M NaAcO
|
Resolution 2.00 Å R-free 0.252 |
| 5GPQ Crystal Structure of zebrafish ASC CARD Domain Deposited 2016-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
Fragment：UNP residues 27-384,UNP residues 119-201
|
Mutation：D83A,K84A,E173A,N174A,K240A | CIT CITRIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；2.0 M Ammonium Citrate, 0.1 M HEPES
|
Resolution 2.10 Å R-free 0.199 |
| 5II4 Crystal structure of red abalone VERL repeat 1 with linker at 2.0 A resolution Deposited 2016-03-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–393（367 aa）
|
Mutation：N4115Q, N4122T, N4142Y, N4171Q,N4115Q, N4122T, N4142Y, N4171Q,N4115Q, N4122T, N4142Y, N4171Q,N4115Q, N4122T, N4142Y, N4171Q | PGE TRIETHYLENE GLYCOL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；40% PEG 600, 0.1M CHES
|
Resolution 2.00 Å R-free 0.247 |
| 5JJ4 Crystal Structure of a Variant Human Activation-induced Deoxycytidine Deaminase as an MBP fusion protein Deposited 2016-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
27–393（367 aa）
Fragment：unp residues 27-384, unp residues 3-183
|
Not recorded | ZN ZINC ION × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；100mM MES pH 6.5, 200mM Calcium Acetate, 15%PEG8000
|
Resolution 2.81 Å R-free 0.232 |
| 5JJ4 Crystal Structure of a Variant Human Activation-induced Deoxycytidine Deaminase as an MBP fusion protein Deposited 2016-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–393（367 aa）
Fragment：unp residues 27-384, unp residues 3-183
|
Not recorded | ZN ZINC ION × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；100mM MES pH 6.5, 200mM Calcium Acetate, 15%PEG8000
|
Resolution 2.81 Å R-free 0.232 |
| 5JJ4 Crystal Structure of a Variant Human Activation-induced Deoxycytidine Deaminase as an MBP fusion protein Deposited 2016-04-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–393（367 aa）
Fragment：unp residues 27-384, unp residues 3-183
|
Not recorded | ZN ZINC ION × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；100mM MES pH 6.5, 200mM Calcium Acetate, 15%PEG8000
|
Resolution 2.81 Å R-free 0.232 |
| 5JON Crystal structure of the unliganded form of HCN2 CNBD Deposited 2016-05-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | NO3 NITRATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；34-36% dimethyl PEG 500, 240 mM potassium nitrate, 20 mM magnesium chloride, 100 mM BIS-TRIS, pH 6.0
|
Resolution 2.04 Å R-free 0.221 |
| 5JON Crystal structure of the unliganded form of HCN2 CNBD Deposited 2016-05-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
|
Not recorded | NO3 NITRATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；34-36% dimethyl PEG 500, 240 mM potassium nitrate, 20 mM magnesium chloride, 100 mM BIS-TRIS, pH 6.0
|
Resolution 2.04 Å R-free 0.221 |
| 5JTQ The structure of chaperone SecB in complex with unstructured MBP binding site d Deposited 2016-05-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain E
108–149（42 aa）
Fragment：residues 108-149
Chain F
108–149（42 aa）
Fragment：residues 108-149
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；301 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
300 uM [U-100% 13C; U-100% 15N] E.coli Chaperone SecB, 300 uM [U-100% 13C; U-100% 15N] E.coli Maltose Binding Protein (MBP) binding site d, 150 mM potassium chloride, 50 mM potassium phosphate, 50 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5JTR The structure of chaperone SecB in complex with unstructured MBP binding site e Deposited 2016-05-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain E
168–207（40 aa）
Fragment：residues 168-207
Chain F
168–207（40 aa）
Fragment：residues 168-207
Chain G
168–207（40 aa）
Fragment：residues 168-207
Chain H
168–207（40 aa）
Fragment：residues 168-207
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；301 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
300 uM [U-100% 13C; U-100% 15N] E.coli Chaperone SecB, 300 uM [U-100% 13C; U-100% 15N] E.coli Maltose Binding Protein (MBP) binding site e, 150 mM potassium chloride, 50 mM sodium phosphate, 50 mM potassium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5K94 Deletion-Insertion Chimera of MBP with the Preprotein Cross-Linking Domain of the SecA ATPase Deposited 2016-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–197（171 aa）
Chain A
202–396（195 aa）
|
Not recorded | B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；50 mM PCB buffer (Qiagen; sodium propionate, sodium cacodylate, bis-tris propane), pH 7.0; 19.5 % PEG 1500; 10% glycerol; 28 mg/mL protein concentration
|
Resolution 2.10 Å R-free 0.230 |
| 5K94 Deletion-Insertion Chimera of MBP with the Preprotein Cross-Linking Domain of the SecA ATPase Deposited 2016-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–197（171 aa）
Chain B
202–396（195 aa）
|
Not recorded | B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；50 mM PCB buffer (Qiagen; sodium propionate, sodium cacodylate, bis-tris propane), pH 7.0; 19.5 % PEG 1500; 10% glycerol; 28 mg/mL protein concentration
|
Resolution 2.10 Å R-free 0.230 |
| 5LDF Maltose binding protein genetically fused to dodecameric glutamine synthetase Deposited 2016-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric |
Chain M
27–396（370 aa）
Chain N
27–396（370 aa）
Chain O
27–396（370 aa）
Chain P
27–396（370 aa）
Chain Q
27–396（370 aa）
Chain R
27–396（370 aa）
Chain S
27–396（370 aa）
Chain T
27–396（370 aa）
Chain U
27–396（370 aa）
Chain V
27–396（370 aa）
Chain W
27–396（370 aa）
Chain X
27–396（370 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.20 Å |
| 5LEL Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein Deposited 2016-06-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
29–392（364 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG3350 23.2% w/v, Sodium acetate 0.2 M, Bis-Tris propane 0.1 M, pH 8.0
|
Resolution 3.10 Å R-free 0.306 |
| 5LEL Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein Deposited 2016-06-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
29–392（364 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG3350 23.2% w/v, Sodium acetate 0.2 M, Bis-Tris propane 0.1 M, pH 8.0
|
Resolution 3.10 Å R-free 0.306 |
| 5LEL Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein Deposited 2016-06-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
29–392（364 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；PEG3350 23.2% w/v, Sodium acetate 0.2 M, Bis-Tris propane 0.1 M, pH 8.0
|
Resolution 3.10 Å R-free 0.306 |
| 5LEM Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_11_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein Deposited 2016-06-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
29–392（364 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；293 K；PEG6000 20% w/v, TAPS 0.02 M, pH 9.0
|
Resolution 2.98 Å R-free 0.295 |
| 5LOF Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 Deposited 2016-08-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：K194A, K197A, R201A,K194A, K197A, R201A | 70R (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；284 K；25% PEG3350, 0.2M Magnesium Formate, 1mM Maltose
|
Resolution 2.20 Å R-free 0.235 |
| 5T03 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and glucuronic acid containing hexasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 NPO P-NITROPHENOL × 1 EDO 1,2-ETHANEDIOL × 11 CL CHLORIDE ION × 3 NA SODIUM ION × 4 TLA L(+)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100mM Tris pH 7.5, 200mM di-sodium tartrate, 18-19% PEG 3350
|
Resolution 2.10 Å R-free 0.212 |
| 5T03 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and glucuronic acid containing hexasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 NPO P-NITROPHENOL × 1 EDO 1,2-ETHANEDIOL × 5 CL CHLORIDE ION × 2 NA SODIUM ION × 2 TLA L(+)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100mM Tris pH 7.5, 200mM di-sodium tartrate, 18-19% PEG 3350
|
Resolution 2.10 Å R-free 0.212 |
| 5T05 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and IdoA2S containing hexasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 NPO P-NITROPHENOL × 1 EDO 1,2-ETHANEDIOL × 9 CL CHLORIDE ION × 3 NA SODIUM ION × 5 TLA L(+)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100mM Tris pH 7.5, 200mM disodium tartrate, 18-19% PEG 3350, 1mM PAP, 5mM maltose, 10mM oligosaccharide ligand
|
Resolution 1.95 Å R-free 0.212 |
| 5T05 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and IdoA2S containing hexasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 NPO P-NITROPHENOL × 1 EDO 1,2-ETHANEDIOL × 6 CL CHLORIDE ION × 1 NA SODIUM ION × 2 TLA L(+)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100mM Tris pH 7.5, 200mM disodium tartrate, 18-19% PEG 3350, 1mM PAP, 5mM maltose, 10mM oligosaccharide ligand
|
Resolution 1.95 Å R-free 0.212 |
| 5T0A Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | NPO P-NITROPHENOL × 1 A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 EDO 1,2-ETHANEDIOL × 11 TLA L(+)-TARTARIC ACID × 2 NA SODIUM ION × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；25mM Tris pH 7.5
200mM disodium tartrate
18-19% PEG3350
1mM PAP
10mM oligosaccharide
5mM maltose
|
Resolution 1.95 Å R-free 0.213 |
| 5T0A Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate Deposited 2016-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
|
Mutation：D82A, K83A, E172A, N173A, K239A, E359A, K362A, D363A | NPO P-NITROPHENOL × 1 A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 EDO 1,2-ETHANEDIOL × 4 TLA L(+)-TARTARIC ACID × 1 NA SODIUM ION × 2 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；25mM Tris pH 7.5
200mM disodium tartrate
18-19% PEG3350
1mM PAP
10mM oligosaccharide
5mM maltose
|
Resolution 1.95 Å R-free 0.213 |
| 5TTD Minor pilin FctB from S. pyogenes with engineered intramolecular isopeptide bond Deposited 2016-11-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
33–392（360 aa）
Fragment：UNP residues 33-392,UNP residues 26-148
|
Not recorded | FMT FORMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；12.5% PEG 1000, 10% PEG 3350, 12.5% MPD, 0.1M MES/imidazole pH 6.5, 0.02 M sodium formate, 0.02 M ammonium acetate, 0.02 M trisodium citrate, 0.02 M sodium potassium L-tartrate, 0.02 M sodium oxamate
|
Resolution 2.00 Å R-free 0.230 |
| 5TTD Minor pilin FctB from S. pyogenes with engineered intramolecular isopeptide bond Deposited 2016-11-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
33–392（360 aa）
Fragment：UNP residues 33-392,UNP residues 26-148
|
Not recorded | FMT FORMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；12.5% PEG 1000, 10% PEG 3350, 12.5% MPD, 0.1M MES/imidazole pH 6.5, 0.02 M sodium formate, 0.02 M ammonium acetate, 0.02 M trisodium citrate, 0.02 M sodium potassium L-tartrate, 0.02 M sodium oxamate
|
Resolution 2.00 Å R-free 0.230 |
| 5V6Y Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant Deposited 2017-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；15% PEG3350, 0.1 M Sodium Malonate pH 6.0, 50 mM Potassium/Sodium tartrate, 1% Cadaverine
|
Resolution 2.80 Å R-free 0.244 |
| 5V6Y Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant Deposited 2017-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；15% PEG3350, 0.1 M Sodium Malonate pH 6.0, 50 mM Potassium/Sodium tartrate, 1% Cadaverine
|
Resolution 2.80 Å R-free 0.244 |
| 5V6Y Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant Deposited 2017-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；15% PEG3350, 0.1 M Sodium Malonate pH 6.0, 50 mM Potassium/Sodium tartrate, 1% Cadaverine
|
Resolution 2.80 Å R-free 0.244 |
| 5V6Y Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant Deposited 2017-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；15% PEG3350, 0.1 M Sodium Malonate pH 6.0, 50 mM Potassium/Sodium tartrate, 1% Cadaverine
|
Resolution 2.80 Å R-free 0.244 |
| 5W0R Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid Deposited 2017-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392, UNP Q9GZX7 residues 13-181
|
Not recorded | ZN ZINC ION × 1 CAC CACODYLATE ION × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；0.05 M sodium cacodylate at pH 5.5, 20 mM MgCl2, 10 mM CaCl2, 10 mM spermidine, 5% PEG3350
|
Resolution 2.40 Å R-free 0.239 |
| 5W0R Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid Deposited 2017-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392, UNP Q9GZX7 residues 13-181
|
Not recorded | ZN ZINC ION × 1 CAC CACODYLATE ION × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；0.05 M sodium cacodylate at pH 5.5, 20 mM MgCl2, 10 mM CaCl2, 10 mM spermidine, 5% PEG3350
|
Resolution 2.40 Å R-free 0.239 |
| 5W0U Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP Deposited 2017-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: trimeric |
Chain B
27–392（366 aa）
Fragment：UNP residues 27-392,UNP residues 13-181
|
Not recorded | ZN ZINC ION × 1 DCM 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE × 1 CA CALCIUM ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；289 K；0.1 M MES at pH 6.2, 3%PEG3350, 10 mM CaCl2, 20mM dCMP
|
Resolution 2.90 Å R-free 0.281 |
| 5W0U Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP Deposited 2017-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：UNP residues 27-392,UNP residues 13-181
|
Not recorded | ZN ZINC ION × 1 DCM 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE × 1 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；289 K；0.1 M MES at pH 6.2, 3%PEG3350, 10 mM CaCl2, 20mM dCMP
|
Resolution 2.90 Å R-free 0.281 |
| 5W0Z Crystal structure of MBP fused activation-induced cytidine deaminase (AID) Deposited 2017-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392,UNP Q9GZX7 residues 13-181
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.26 M NaCl, 0.1 M MES pH
6.0, 12% PEG3350
|
Resolution 3.61 Å R-free 0.307 |
| 5W0Z Crystal structure of MBP fused activation-induced cytidine deaminase (AID) Deposited 2017-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
Fragment：UNP P0AEY0 residues 27-392,UNP Q9GZX7 residues 13-181
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.26 M NaCl, 0.1 M MES pH
6.0, 12% PEG3350
|
Resolution 3.61 Å R-free 0.307 |
| 5W1C Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cytidine Deposited 2017-06-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain A
27–392（366 aa）
Chain B
27–392（366 aa）
|
Not recorded | ZN ZINC ION × 2 CTN 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE × 2 CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；289 K；0.1 M MES at pH 6.2, 3% PEG3350, 10 mM CaCl2 and 20mM Cytidine
|
Resolution 3.18 Å R-free 0.270 |
| 5ZD4 Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA Deposited 2018-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain C
27–392（366 aa）
Chain D
27–392（366 aa）
|
Mutation：D108A,K109A,E198A,N199A,K265A,E385A,K388A,D389A Mutation：D108A,K109A,E198A,N199A,K265A,E385A,K388A,D389A | EDO 1,2-ETHANEDIOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；50mM sodium cacodylate (pH 6.5), 200mM potassium chloride, 10% (w/v) polyethylene glycol (PEG) 4000
|
Resolution 2.17 Å R-free 0.244 |
| 5ZD4 Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA Deposited 2018-02-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain A
27–392（366 aa）
Chain B
27–392（366 aa）
|
Mutation：D108A,K109A,E198A,N199A,K265A,E385A,K388A,D389A Mutation：D108A,K109A,E198A,N199A,K265A,E385A,K388A,D389A | EDO 1,2-ETHANEDIOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；50mM sodium cacodylate (pH 6.5), 200mM potassium chloride, 10% (w/v) polyethylene glycol (PEG) 4000
|
Resolution 2.17 Å R-free 0.244 |
| 6AEO TssL periplasmic domain Deposited 2018-08-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG MME 2000, KSCN
|
Resolution 2.30 Å R-free 0.229 |
| 6AEO TssL periplasmic domain Deposited 2018-08-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–392（366 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG MME 2000, KSCN
|
Resolution 2.30 Å R-free 0.229 |
| 6ANV Crystal structure of anti-CRISPR protein AcrF1 Deposited 2017-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–396（370 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PGE TRIETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 3 PEG DI(HYDROXYETHYL)ETHER × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 6.2；293 K；0.1 M MES (pH 6.2), 2.5% PEG 3000 (v/v), and 42% PEG400 (v/v)
|
Resolution 2.27 Å R-free 0.223 |
| 6ANV Crystal structure of anti-CRISPR protein AcrF1 Deposited 2017-08-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–396（370 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PGE TRIETHYLENE GLYCOL × 2 EDO 1,2-ETHANEDIOL × 4 PEG DI(HYDROXYETHYL)ETHER × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 6.2；293 K；0.1 M MES (pH 6.2), 2.5% PEG 3000 (v/v), and 42% PEG400 (v/v)
|
Resolution 2.27 Å R-free 0.223 |
| 6BUZ Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N Deposited 2017-12-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: undecameric |
Chain N
26–394（369 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.92 Å |
| 6D1U Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin Deposited 2018-04-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
26–392（367 aa）
|
Not recorded | NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；13% v/v PEG 3,350
0.1 M Na cacodylate, pH 6.5
0.15 M DL-malic acid
|
Resolution 2.05 Å R-free 0.223 |
| 6D1U Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin Deposited 2018-04-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；13% v/v PEG 3,350
0.1 M Na cacodylate, pH 6.5
0.15 M DL-malic acid
|
Resolution 2.05 Å R-free 0.223 |
| 6D1U Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin Deposited 2018-04-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
26–392（367 aa）
|
Not recorded | NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；13% v/v PEG 3,350
0.1 M Na cacodylate, pH 6.5
0.15 M DL-malic acid
|
Resolution 2.05 Å R-free 0.223 |
| 6DD5 Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein Deposited 2018-05-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–384（358 aa）
|
Not recorded | GOL GLYCEROL × 1 SO4 SULFATE ION × 9 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.2；295 K；0.1 M Sodium Acetate, 2.5 M Ammonium Sulfate
|
Resolution 2.85 Å R-free 0.225 |
| 6DD5 Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein Deposited 2018-05-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–384（358 aa）
|
Not recorded | GOL GLYCEROL × 1 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.2；295 K；0.1 M Sodium Acetate, 2.5 M Ammonium Sulfate
|
Resolution 2.85 Å R-free 0.225 |
| 6DKS Structure of the Rbpj-SHARP-DNA Repressor Complex Deposited 2018-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–DNA Heteromer；Protein × 4 PDB declaration: octameric |
Chain D
28–392（365 aa）
Fragment：residues 28-392
Chain H
28–392（365 aa）
Fragment：residues 28-392
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；277 K；Bis-Tris pH6.6
100mM NaCl
40% PEG400
200mM NDSB-256
|
Resolution 2.78 Å R-free 0.228 |
| 6DKS Structure of the Rbpj-SHARP-DNA Repressor Complex Deposited 2018-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric |
Chain D
28–392（365 aa）
Fragment：residues 28-392
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；277 K；Bis-Tris pH6.6
100mM NaCl
40% PEG400
200mM NDSB-256
|
Resolution 2.78 Å R-free 0.228 |
| 6DKS Structure of the Rbpj-SHARP-DNA Repressor Complex Deposited 2018-05-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric |
Chain H
28–392（365 aa）
Fragment：residues 28-392
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；277 K；Bis-Tris pH6.6
100mM NaCl
40% PEG400
200mM NDSB-256
|
Resolution 2.78 Å R-free 0.228 |
| 6EG2 Crystal structure of human BRM in complex with compound 16 Deposited 2018-08-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
27–392（366 aa）
|
Not recorded | J7J N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea × 2 IPA ISOPROPYL ALCOHOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；100mM Hepes pH7.5, 200mM sodium chloride, 8% isopropanol
|
Resolution 2.98 Å R-free 0.304 |
| 6EG3 Crystal structure of human BRM in complex with compound 15 Deposited 2018-08-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | J7G 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid × 1 EOH ETHANOL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；100mM Tris pH7, 14% Ethanol
|
Resolution 2.84 Å R-free 0.267 |
| 6EQZ A MamC-MIC insertion in MBP scaffold at position K170 Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–195（169 aa）
Chain A
207–392（186 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1,86 M Tris-Ammonium citrate
|
Resolution 2.29 Å R-free 0.274 |
| 6EQZ A MamC-MIC insertion in MBP scaffold at position K170 Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
27–195（169 aa）
Chain B
207–392（186 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1,86 M Tris-Ammonium citrate
|
Resolution 2.29 Å R-free 0.274 |
| 6EQZ A MamC-MIC insertion in MBP scaffold at position K170 Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
27–195（169 aa）
Chain D
207–392（186 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1,86 M Tris-Ammonium citrate
|
Resolution 2.29 Å R-free 0.274 |
| 6EQZ A MamC-MIC insertion in MBP scaffold at position K170 Deposited 2017-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
27–195（169 aa）
Chain G
207–392（186 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1,86 M Tris-Ammonium citrate
|
Resolution 2.29 Å R-free 0.274 |
| 6N84 MBP-fusion protein of transducin-alpha residues 327-350 Deposited 2018-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：D83A, K84A, E173A, N174A, A216H, K220H, K240A | SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；2 M Ammonium Sulphate, 0.1 M sodium acetate, pH 4.6
|
Resolution 1.75 Å R-free 0.185 |
| 6N85 Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350 Deposited 2018-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain M
27–392（366 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；0.1 M MIB buffer, 25 % PEG3350pH 8.0
|
Resolution 2.50 Å R-free 0.249 |
| 6QGD Structure of human Mcl-1 in complex with thienopyrimidine inhibitor Deposited 2019-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | J1N 2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)amino]-3-oxidanyl-propanoic acid × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 1.80 Å R-free 0.208 |
| 6QXJ Structure of MBP-Mcl-1 in complex with compound 6a Deposited 2019-03-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：K194A, K197A, R201A,K194A, K197A, R201A | JKQ (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]amino]propanoic acid × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；279 K；25% PEG3350, 0.2M MAGNESIUM FORMATE,1MM MALTOSE
|
Resolution 1.70 Å R-free 0.203 |
| 6QYK Structure of MBP-Mcl-1 in complex with compound 7a Deposited 2019-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | JLB (2~{R})-2-[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]oxypropanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 2.30 Å R-free 0.266 |
| 6QYL Structure of MBP-Mcl-1 in complex with compound 8a Deposited 2019-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | JLE (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 2.20 Å R-free 0.235 |
| 6QYN Structure of MBP-Mcl-1 in complex with compound 10d Deposited 2019-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | JL8 (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 2.50 Å R-free 0.251 |
| 6QYO Structure of MBP-Mcl-1 in complex with compound 18a Deposited 2019-03-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | JLH (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 2.10 Å R-free 0.221 |
| 6QZ7 Structure of MBP-Mcl-1 in complex with compound 8b Deposited 2019-03-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | JLE (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；284 K；25% PEG3350, 0.2M MAGNESIUM FORMATE, 1MM MALTOSE
|
Resolution 2.20 Å R-free 0.211 |
| 6YBJ Structure of MBP-Mcl-1 in complex with compound 3e Deposited 2020-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：K194A,K197A,R201A | CL CHLORIDE ION × 1 OJW (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M BisTris buffer pH 6.5, 20% PegMME5K
|
Resolution 2.50 Å R-free 0.237 |
| 6YBK Structure of MBP-Mcl-1 in complex with compound 4d Deposited 2020-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：K194A,K197A,R201A | CL CHLORIDE ION × 1 OK2 (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-(pyrazin-2-ylmethoxy)phenyl]propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；0.1M BisTris buffer pH 6.5, 20% PegMME5K
|
Resolution 2.00 Å R-free 0.235 |
| 6YBL Structure of MBP-Mcl-1 in complex with compound 9m Deposited 2020-03-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：K194A,K197A,R201A | OK5 (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M BisTris buffer pH 6.5, 20% PegMME5K
|
Resolution 2.10 Å R-free 0.228 |
| 7ZNJ Structure of an ALYREF-exon junction complex hexamer Deposited 2022-04-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 24 PDB declaration: 30-meric |
Chain D
23–392（370 aa）
Chain I
23–392（370 aa）
Chain N
23–392（370 aa）
Chain d
23–392（370 aa）
Chain i
23–392（370 aa）
Chain n
23–392（370 aa）
|
Not recorded | MG MAGNESIUM ION × 6 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 6 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.40 Å |
| 8C8F Crystal structure of the E. coli maltodextrin-binding protein Deposited 2023-01-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–396（396 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Tris pH 7.4, 30 % PEG Smear
Broad, 0.1 M NaBr and 0.1 M KSCN
|
Resolution 1.15 Å R-free 0.152 |
| 8ETB the crystal structure of a rationally designed zinc sensor based on maltose binding protein - Zn binding conformation Deposited 2022-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | ZN ZINC ION × 1 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2M MgCl2 , 0.1 M Bis-Tris, pH 6.5, 25% PEG 3350.
|
Resolution 1.63 Å R-free 0.234 |
| 8F23 The crystal structure of a rationally designed zinc sensor based on maltose binding protein - Apo conformation Deposited 2022-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.2M sodium formate, pH 7.0, 20% PEG 3350
|
Resolution 1.93 Å R-free 0.229 |
| 8GCR HPV16 E6-E6AP-p53 complex Deposited 2023-03-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
27–396（370 aa）
|
Mutation：C87S,C104S,C118S,C147S | ZN ZINC ION × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.38 Å |
| 8H68 Crystal structure of Caenorhabditis elegans NMAD-1 in complex with NOG and Mg(II) Deposited 2022-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLY GLYCINE × 1 OGA N-OXALYLGLYCINE × 1 MG MAGNESIUM ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289 K；0.1 M HEPES, pH 7.5, 10% (w/v) PEG 6000, 10% (v/v) MPD
|
Resolution 2.20 Å R-free 0.242 |
| 8SOJ Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA Deposited 2023-04-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
27–392（366 aa）
|
Not recorded | ZN ZINC ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 8SOK Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA Deposited 2023-04-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: hexameric |
Chain A
27–392（366 aa）
|
Not recorded | ZN ZINC ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.10 Å |
| 8SQA The cryo-EM structure of the EcBAM/EspP(beta8-12) complex Deposited 2023-05-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric |
Chain F
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.20 Å |
| 8SVY MBP-Mcl1 in complex with ligand 10 Deposited 2023-05-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 4 GOL GLYCEROL × 1 WUC (15P)-17-chloro-33-fluoro-12-[(2-methoxyethoxy)methyl]-5,14,22-trimethyl-28-oxa-9-thia-5,6,13,14,22-pentaazaheptacyclo[27.7.1.1~4,7~.0~11,15~.0~16,21~.0~20,24~.0~30,35~]octatriaconta-1(36),4(38),6,11(15),12,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；285 K；19% (w/v) PEG3350, 0.17M Mg formate
|
Resolution 1.47 Å R-free 0.206 |
| 8T2I Negative stain EM assembly of MYC, JAZ, and NINJA complex Deposited 2023-06-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain M
27–392（366 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.8
|
Resolution 10.40 Å |
| 8W23 Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map). Deposited 2024-02-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 20 PDB declaration: eicosameric |
Chain A
28–392（365 aa）
Chain B
28–392（365 aa）
Chain C
28–392（365 aa）
Chain D
28–392（365 aa）
Chain E
28–392（365 aa）
Chain F
28–392（365 aa）
Chain G
28–392（365 aa）
Chain H
28–392（365 aa）
Chain I
28–392（365 aa）
Chain K
28–392（365 aa）
Chain L
28–392（365 aa）
Chain M
28–392（365 aa）
Chain N
28–392（365 aa）
Chain O
28–392（365 aa）
Chain P
28–392（365 aa）
Chain Q
28–392（365 aa）
Chain R
28–392（365 aa）
Chain S
28–392（365 aa）
Chain T
28–392（365 aa）
Chain U
28–392（365 aa）
|
Not recorded | ZN ZINC ION × 20 A1AE4 N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide × 20 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5；Sample was purified and concentrated in the above buffer but exchanged prior to vitrification to a low-salt (minimal) buffer composed of 20 millimolar HEPES pH 7.5. Sample buffer was exchanged on grid via manual side-blotting.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.28 Å |
| 8W25 Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (focused refinement map). Deposited 2024-02-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
28–392（365 aa）
Chain Q
28–392（365 aa）
|
Not recorded | ZN ZINC ION × 2 A1AE4 N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5；Sample was purified and concentrated in the above buffer but exchanged prior to vitrification to a low-salt (minimal) buffer composed of 20 millimolar HEPES pH 7.5. Sample buffer was exchanged on grid via manual side-blotting.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.42 Å |
| 8W27 Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (consensus map). Deposited 2024-02-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 20 PDB declaration: 20-meric |
Chain A
28–392（365 aa）
Chain B
28–392（365 aa）
Chain C
28–392（365 aa）
Chain D
28–392（365 aa）
Chain E
28–392（365 aa）
Chain F
28–392（365 aa）
Chain G
28–392（365 aa）
Chain H
28–392（365 aa）
Chain I
28–392（365 aa）
Chain J
28–392（365 aa）
Chain L
28–392（365 aa）
Chain M
28–392（365 aa）
Chain N
28–392（365 aa）
Chain O
28–392（365 aa）
Chain P
28–392（365 aa）
Chain Q
28–392（365 aa）
Chain R
28–392（365 aa）
Chain S
28–392（365 aa）
Chain T
28–392（365 aa）
Chain U
28–392（365 aa）
|
Not recorded | XAV 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol × 20 ZN ZINC ION × 20 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5；Sample was purified and concentrated in the above buffer but exchanged prior to vitrification to a low-salt (minimal) buffer composed of 20 millimolar HEPES pH 7.5. Sample buffer was exchanged on grid via manual side-blotting.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.21 Å |
| 8W28 Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (focused refinement map). Deposited 2024-02-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
28–392（365 aa）
Chain Q
28–392（365 aa）
|
Not recorded | XAV 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol × 2 ZN ZINC ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5；Sample was purified and concentrated in the above buffer but exchanged prior to vitrification to a low-salt (minimal) buffer composed of 20 millimolar HEPES pH 7.5. Sample buffer was exchanged on grid via manual side-blotting.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.19 Å |
| 8Y20 Crystal structure of the Mcl-1 in complex with A-1210477 Deposited 2024-01-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：E173A,N174A,K240A,K391A,K394A,R398A | A1LXV A-1210477 × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；25% PEG 3350, 0.2M Magnesium Formate, 1mM Maltose
|
Resolution 2.23 Å R-free 0.243 |
| 9GIV Structure of the human mitochondrial pyruvate carrier inhibited by a UK5099-derivative Deposited 2024-08-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | A1IL4 (2E)-2-cyano-3-[(5M)-5-(2-nitrophenyl)furan-2-yl]prop-2-enoic acid × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.65 Å |
| 9GIW Structure of the human mitochondrial pyruvate carrier inhibited by zaprinast Deposited 2024-08-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | A1IL3 5-(2-propoxyphenyl)-3,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.92 Å |
| 9GIX Structure of the human mitochondrial pyruvate carrier in the apo-state Deposited 2024-08-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.65 Å |
| 9GIY Structure of the human mitochondrial pyruvate carrier inhibited by mitoglitazone Deposited 2024-08-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | LO7 Mitoglitazone × 1 A1IMZ Mitoglitazone (R-form) × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.79 Å |
| 9H2Q Stabilized complex of Chlamydia trachomatic efector CT622 in complex with human WD40 domain of ATG16L1 Deposited 2024-10-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
27–395（369 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 6
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.80 Å |
| 9I3P CryoEM structure of the Themis:Grb2 complex with bound ProMacrobody 256 Deposited 2025-01-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM Tris pH8, 100 mM NaCl, 2 mM DTT with added 8 mM CHAPSO for cryogrid sample preparation
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 5 s blotting time
|
Resolution 3.30 Å |
| 9IAZ CryoEM structure of the Themis:Grb2 complex with bound ProMacrobody 256, local refinement Deposited 2025-02-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
33–392（360 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8；25 mM Tris pH8, 100 mM NaCl, 2 mM DTT with added 8 mM CHAPSO for cryogrid sample preparation
cryo-EM vitrification conditions
Cryogen ETHANE；Leica EM GP2, 5 s blotting time
|
Resolution 3.20 Å |
| 9MAN Structure of Norrin in complex with human Tspan12 large extracellular loop (Tspan12 LEL) Deposited 2025-03-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
26–392（367 aa）
Chain B
26–392（367 aa）
Chain C
26–392（367 aa）
Chain D
26–392（367 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.78 Å |
| 9ME8 Co-crystal structure of maltose binding protein (MBP)-human SENP3 fusion protein in complex with PELP1 peptide Deposited 2024-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
27–384（358 aa）
|
Mutation：C532S | NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.085M HEPES pH 7.5, 17-20% (v/v) PEG8000
|
Resolution 2.93 Å R-free 0.232 |
| 9P0X Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted) Deposited 2025-06-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 7 PDB declaration: heptameric |
Chain T
27–392（366 aa）
|
Not recorded | MG MAGNESIUM ION × 4 CA CALCIUM ION × 12 BGC beta-D-glucopyranose × 1 FUC alpha-L-fucopyranose × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 9QBJ Legobody dimer Deposited 2025-03-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric |
Chain I
27–384（358 aa）
Chain J
27–384（358 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9UYY Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with L-Trp Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 EDO 1,2-ETHANEDIOL × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 TRP TRYPTOPHAN × 1 CYN CYANIDE ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.25 Å R-free 0.300 |
| 9UYZ Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with 5-HT Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | SRO SEROTONIN × 1 EDO 1,2-ETHANEDIOL × 3 PEG DI(HYDROXYETHYL)ETHER × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.45 Å R-free 0.264 |
| 9UZ0 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) as resting state Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 CIT CITRIC ACID × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.45 Å R-free 0.248 |
| 9UZ1 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) H143Y mutant complexed with L-Trp Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Mutation：H143Y | TRP TRYPTOPHAN × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CIT CITRIC ACID × 1 EDO 1,2-ETHANEDIOL × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.35 Å R-free 0.236 |
| 9UZ2 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with Cyanide ion Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | CIT CITRIC ACID × 1 EDO 1,2-ETHANEDIOL × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.55 Å R-free 0.238 |
| 9UZ3 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with D-Trp Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 DTR D-TRYPTOPHAN × 1 EDO 1,2-ETHANEDIOL × 4 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.50 Å R-free 0.275 |
| 9UZ4 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with 5-methoxy-L-Trp Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | A1A2Y 5-methoxy-L-tryptophan × 1 EDO 1,2-ETHANEDIOL × 12 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.50 Å R-free 0.280 |
| 9UZ5 Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with 5-methyl-L-Trp Deposited 2025-05-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
27–392（366 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 1 CYN CYANIDE ION × 1 D0Q 5-methyl-L-tryptophan × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 3350, Sodium citrate tribasic dihydrate
|
Resolution 2.50 Å R-free 0.229 |
| 9VFI Structure of hTRPC3 solubilized with 4F peptide at 2.72 angstrom Deposited 2025-06-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
27–392（366 aa）
Chain B
27–392（366 aa）
Chain C
27–392（366 aa）
Chain D
27–392（366 aa）
|
Not recorded | CA CALCIUM ION × 8 ZN ZINC ION × 4 A1L5I [(2~{S})-2-[(~{E})-octadec-9-enoyl]oxy-3-oxidanyl-propyl] octadec-9-enoate × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.72 Å |
| 9W3K GPR151-Legobody complex Deposited 2025-07-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
27–394（368 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.08 Å |
109 other PDB entries and 148 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | MALE_ECO57 |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–358； UniProt 27–384 Author chain B； PDBConstruct 1–358； UniProt 27–384 Author chain C； PDBConstruct 1–358； UniProt 27–384 |
